Statistical Modeling of the Drug Load Distribution on Trastuzumab Emtansine (Kadcyla), a Lysine-Linked Antibody Drug Conjugate

2014 ◽  
Vol 25 (7) ◽  
pp. 1223-1232 ◽  
Author(s):  
Michael T. Kim ◽  
Yan Chen ◽  
Joseph Marhoul ◽  
Fred Jacobson
Keyword(s):  
Statistical Modeling ◽  
Load Distribution ◽  
Trastuzumab Emtansine ◽  
Antibody Drug Conjugate ◽  
Drug Load ◽  
Drug Conjugate ◽  
Antibody Drug

scholarly journals Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine-linked antibody drug conjugate

2015 ◽  
Vol 24 (8) ◽  
pp. 1210-1223 ◽  
Author(s):  
Julien Marcoux ◽  
Thierry Champion ◽  
Olivier Colas ◽  
Elsa Wagner-Rousset ◽  
Nathalie Corvaïa ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Native Mass Spectrometry ◽  
Trastuzumab Emtansine ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Antibody Drug

scholarly journals Evolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1)

2016 ◽  
Vol 18 (4) ◽  
pp. 861-875 ◽  
Author(s):  
Aman P. Singh ◽  
Katie F. Maass ◽  
Alison M. Betts ◽  
K. Dane Wittrup ◽  
Chethana Kulkarni ◽  
...  
Keyword(s):  
Trastuzumab Emtansine ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Tumor Pharmacokinetics ◽  
Disposition Model ◽  
Antibody Drug
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