Active site labeling of the Yersinia protein tyrosine phosphatase: The determination of the pKa of the active site cysteine and the function of the conserved histidine 402

Biochemistry ◽  
1993 ◽  
Vol 32 (36) ◽  
pp. 9340-9345 ◽  
Author(s):  
Zhong Yin Zhang ◽  
Jack E. Dixon
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Active Site ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine ◽  
Active Site Cysteine

scholarly journals Singlet oxygen inactivates protein tyrosine phosphatase-1B by oxidation of the active site cysteine

2006 ◽  
Vol 387 (10/11) ◽  
Author(s):  
Claudia von Montfort ◽  
Victor S. Sharov ◽  
Sabine Metzger ◽  
Christian Schöneich ◽  
Helmut Sies ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Protein Tyrosine Phosphatase ◽  
Active Site ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Active Site Cysteine

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

Nature ◽  
2003 ◽  
Vol 423 (6941) ◽  
pp. 773-777 ◽  
Author(s):  
Rob L. M. van Montfort ◽  
Miles Congreve ◽  
Dominic Tisi ◽  
Robin Carr ◽  
Harren Jhoti
Keyword(s):  
Oxidation State ◽  
Protein Tyrosine Phosphatase ◽  
Active Site ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Active Site Cysteine
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