4-Bromo-2-octenoic acid specifically inactivates 3-ketoacyl-CoA thiolase and thereby fatty acid oxidation in rat liver mitochondria

Biochemistry ◽  
1988 ◽  
Vol 27 (16) ◽  
pp. 5995-6000 ◽  
Author(s):  
Jianxun Li ◽  
Horst Schulz
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Acid Oxidation

scholarly journals A 22 kDa polyanion inhibits carnitine-dependent fatty acid oxidation in rat liver mitochondria

FEBS Letters ◽  
1999 ◽  
Vol 460 (2) ◽  
pp. 241-245 ◽  
Author(s):  
Peter Turkaly ◽  
Janos Kerner ◽  
Charles Hoppel
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Acid Oxidation

scholarly journals Effects of pantethine and its metabolites on fatty acid oxidation in rat liver mitochondria.

1983 ◽  
Vol 141 (1) ◽  
pp. 33-39 ◽  
Author(s):  
NOBUHIRO MORISAKI ◽  
NOBUO MATSUOKA ◽  
YASUSHI SAITO ◽  
AKIRA KUMAGAI
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Acid Oxidation

scholarly journals Effect of Riboflavin Deficiency on Fatty Acid Oxidation of Rat Liver Mitochondria

1972 ◽  
Vol 25 (9) ◽  
pp. 681-685
Author(s):  
Misako Taniguchi ◽  
Ryoko Yamauchi ◽  
Motoomi Nakamura
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Acid Oxidation ◽  
Riboflavin Deficiency

Fatty acid oxidation in isolated rat liver mitochondria

1979 ◽  
Vol 197 (2) ◽  
pp. 560-569 ◽  
Author(s):  
Yu-Yan Yeh ◽  
Paulus Zee
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Acid Oxidation ◽  
Isolated Rat Liver ◽  
Isolated Rat

scholarly journals Importance of experimental conditions in evaluating the malonyl-CoA sensitivity of liver carnitine acyltransferase. Studies with fed and starved rats

1981 ◽  
Vol 200 (2) ◽  
pp. 217-223 ◽  
Author(s):  
J D McGarry ◽  
D W Foster
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Rat Liver ◽  
Competitive Inhibition ◽  
Physiological Role ◽  
Rat Liver Mitochondria ◽  
Acid Oxidation ◽  
Carnitine Acyltransferase ◽  
Malonyl Coa

The experiments reconfirm the powerful inhibitory effect of malonyl-CoA on carnitine acyltransferase I and fatty acid oxidation in rat liver mitochondria (Ki 1.5 microM). Sensitivity decreased with starvation (Ki after 18 h starvation 3.0 microM, and after 42 h 5.0 microM). Observations by Cook, Otto & Cornell [Biochem. J. (1980) 192, 955--958] and Ontko & Johns [Biochem. J. (1980) 192, 959--962] have cast doubt on the physiological role of malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis. The high Ki values obtained in the cited studies are shown to be due to incubation conditions that cause substrate depletion, destruction of malonyl-CoA or generation of excessively high concentrations of unbound acyl-CoA (which offsets the competitive inhibition of malonyl-CoA towards carnitine acyltransferase I). The present results are entirely consistent with the postulated role of malonyl-CoA as the primary regulatory of fatty acid synthesis and oxidation in rat liver.

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