Probing the functional role of threonine-113 of Escherichia coli dihydrofolate reductase for its effect on turnover efficiency, catalysis, and binding

Biochemistry ◽  
1989 ◽  
Vol 28 (2) ◽  
pp. 478-486 ◽  
Author(s):  
C. A. Fierke ◽  
Stephen J. Benkovic
Keyword(s):  
Escherichia Coli ◽  
Dihydrofolate Reductase ◽  
Functional Role

Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis

Biochemistry ◽  
1991 ◽  
Vol 30 (46) ◽  
pp. 11092-11103 ◽  
Author(s):  
Mark S. Warren ◽  
Katherine A. Brown ◽  
Martin F. Farnum ◽  
Elizabeth E. Howell ◽  
Joseph Kraut
Keyword(s):  
Escherichia Coli ◽  
Dihydrofolate Reductase ◽  
Functional Role ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis

Probing the functional role of phenylalanine-31 of Escherichia coli dihydrofolate reductase by site-directed mutagenesis

Biochemistry ◽  
1987 ◽  
Vol 26 (13) ◽  
pp. 4093-4100 ◽  
Author(s):  
Jin Tann Chen ◽  
Kazunari Taira ◽  
Chen Pei D. Tu ◽  
Stephen J. Benkovic
Keyword(s):  
Escherichia Coli ◽  
Dihydrofolate Reductase ◽  
Functional Role ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis

Functional role of a mobile loop of Escherichia coli dihydrofolate reductase in transition-state stabilization

Biochemistry ◽  
1992 ◽  
Vol 31 (34) ◽  
pp. 7826-7833 ◽  
Author(s):  
Luyuan Li ◽  
Peter E. Wright ◽  
Stephen J. Benkovic ◽  
Christopher J. Falzone
Keyword(s):  
Escherichia Coli ◽  
Transition State ◽  
Dihydrofolate Reductase ◽  
Functional Role ◽  
Transition State Stabilization

scholarly journals Role of aspartate 27 in the binding of methotrexate to dihydrofolate reductase from Escherichia coli.

1988 ◽  
Vol 263 (19) ◽  
pp. 9187-9198 ◽  
Author(s):  
J R Appleman ◽  
E E Howell ◽  
J Kraut ◽  
M Kühl ◽  
R L Blakley
Keyword(s):  
Escherichia Coli ◽  
Dihydrofolate Reductase

Sequence Perturbation Analysis: Addressing Amino Acid Indices to Elucidate the C-Terminal Role of Escherichia Coli Dihydrofolate Reductase

2009 ◽  
Vol 145 (6) ◽  
pp. 751-762 ◽  
Author(s):  
Hisashi Takahashi ◽  
Akiko Yokota ◽  
Tatsuyuki Takenawa ◽  
Masahiro Iwakura
Keyword(s):  
Escherichia Coli ◽  
Amino Acid ◽  
Dihydrofolate Reductase ◽  
Perturbation Analysis ◽  
Amino Acid Indices

Kinetic investigation of the functional role of phenylalanine-31 of recombinant human dihydrofolate reductase

Biochemistry ◽  
1990 ◽  
Vol 29 (27) ◽  
pp. 6428-6436 ◽  
Author(s):  
Jiu Tsair Tsay ◽  
James R. Appleman ◽  
William A. Beard ◽  
Neal J. Prendergast ◽  
Tavner J. Delcamp ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
Functional Role ◽  
Kinetic Investigation ◽  
Human Dihydrofolate Reductase

Dihydrofolate reductase from Escherichia coli: probing the role of aspartate-27 and phenylalanine-137 in enzyme conformation and the binding of NADPH

Biochemistry ◽  
1990 ◽  
Vol 29 (37) ◽  
pp. 8569-8576 ◽  
Author(s):  
Susan M. J. Dunn ◽  
Thomas M. Lanigan ◽  
Elizabeth E. Howell
Keyword(s):  
Escherichia Coli ◽  
Dihydrofolate Reductase

Functional role of a non-active site residue Trp23 on the enzyme activity of Escherichia coli thioesterase I/protease I/lysophospholipase L1

2009 ◽  
Vol 1794 (10) ◽  
pp. 1467-1473 ◽  
Author(s):  
Li-Chiun Lee ◽  
Yi-Li Chou ◽  
Hong-Hwa Chen ◽  
Ya-Lin Lee ◽  
Jei-Fu Shaw
Keyword(s):  
Escherichia Coli ◽  
Enzyme Activity ◽  
Active Site ◽  
Functional Role ◽  
Active Site Residue

scholarly journals Analysis of the functional role of conserved residues in the protein subunit of ribonuclease P from Escherichia coli

1997 ◽  
Vol 267 (4) ◽  
pp. 818-829 ◽  
Author(s):  
Venkat Gopalan ◽  
Andreas D Baxevanis ◽  
David Landsman ◽  
Sidney Altman
Keyword(s):  
Escherichia Coli ◽  
Functional Role ◽  
Ribonuclease P ◽  
Protein Subunit ◽  
Conserved Residues
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