Human leukocyte and porcine pancreatic elastase: x-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors

Structural Analysis of the Active Site of Porcine Pancreatic Elastase Based on the X-ray Crystal Structures of Complexes with Trifluoroacetyl-Dipeptide-Anilide Inhibitors

Biochemistry ◽

10.1021/bi00010a008 ◽

1995 ◽

Vol 34 (10) ◽

pp. 3193-3203 ◽

Cited By ~ 21

Author(s):

Carla Mattos ◽

Debra Ann Giammona ◽

Gregory A. Petsko ◽

Dagmar Ringe

Keyword(s):

Structural Analysis ◽

Crystal Structures ◽

Active Site ◽

Pancreatic Elastase ◽

X Ray ◽

Inhibition of Human Leukocyte and Porcine Pancreatic Elastase by Homologues of Bovine Pancreatic Trypsin Inhibitor†

Biochemistry ◽

10.1021/bi953013b ◽

1996 ◽

Vol 35 (28) ◽

pp. 9090-9096 ◽

Cited By ~ 117

Author(s):

James A. E. Kraunsoe ◽

Timothy D. W. Claridge ◽

Gordon Lowe

Keyword(s):

Trypsin Inhibitor ◽

Human Leukocyte ◽

Bovine Pancreatic Trypsin Inhibitor ◽

Pancreatic Elastase ◽

Pancreatic Trypsin Inhibitor ◽

ChemInform Abstract: Inhibition of Human Leukocyte Elastase, Porcine Pancreatic Elastase and Chymotrypsin by Elasnin and Other 4-Hydroxy-2-pyrones.

Chemischer Informationsdienst ◽

10.1002/chin.198613191 ◽

1986 ◽

Vol 17 (13) ◽

Author(s):

R. W. SPENCER ◽

L. J. COPP ◽

J. R. PFISTER

Keyword(s):

Human Leukocyte ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽

X-ray diffraction analysis of the inhibition of porcine pancreatic elastase by a peptidyl trifluoromethylketone

Journal of Molecular Biology ◽

10.1016/0022-2836(88)90148-9 ◽

1988 ◽

Vol 201 (2) ◽

pp. 423-428 ◽

Cited By ~ 46

Author(s):

Lori H. Takahashi ◽

R. Radhakrishnan ◽

Richard E. Rosenfield ◽

Edgar F. Meyer ◽

Diane Amy Trainor ◽

...

Keyword(s):

Diffraction Analysis ◽

X Ray Diffraction ◽

Pancreatic Elastase ◽

X Ray ◽

New mechanism based serine protease inhibitors: inhibition of human leukocyte elastase, porcine pancreatic elastase, human leukocyte cathepsin G, and chymotrypsin by 3-chloroisocoumarin and 3,3-dichlorophthalide

Journal of the American Chemical Society ◽

10.1021/ja00359a042 ◽

1983 ◽

Vol 105 (21) ◽

pp. 6518-6520 ◽

Cited By ~ 19

Author(s):

J. Wade Harper ◽

Keiji Hemmi ◽

James C. Powers

Keyword(s):

Serine Protease ◽

Protease Inhibitors ◽

Human Leukocyte ◽

Cathepsin G ◽

Serine Protease Inhibitors ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽

Inhibition of the human leukocyte endopeptidases elastase and cathepsin G and of porcine pancreatic elastase by N-oleoyl derivatives of heparin

Biochemical Pharmacology ◽

10.1016/0006-2952(93)90321-m ◽

1993 ◽

Vol 46 (9) ◽

pp. 1545-1549 ◽

Cited By ~ 33

Author(s):

Antonio Baici ◽

Csaba Diczházi ◽

András Neszmélyi ◽

Elemér Móczár ◽

William Hornebeck

Keyword(s):

Human Leukocyte ◽

Cathepsin G ◽

Pancreatic Elastase ◽

Porcine Pancreatic Elastase ◽

Derivatives Of

Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin A.alpha., and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates

Biochemistry ◽

10.1021/bi00308a023 ◽

1984 ◽

Vol 23 (13) ◽

pp. 2995-3002 ◽

Cited By ~ 78

Author(s):

J. Wade Harper ◽

Robert R. Cook ◽

C. Justine Roberts ◽

Beth H. McLaughlin ◽

James C. Powers

Keyword(s):

Active Site ◽

Serine Proteases ◽

Human Leukocyte ◽

Cathepsin G ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽

Site Mapping ◽

Porcine Pancreatic Elastase ◽

And Staphylococcus Aureus

A Molecular Modeling Based upon an X-Ray Crystal Structure: The Enzyme-Ligand Complexes between Porcine Pancreatic Elastase and Acetyl-Alanine-Alanine(Glycine)-Alanine

Quantitative Structure-Activity Relationships ◽

10.1002/qsar.19870060203 ◽

1987 ◽

Vol 6 (2) ◽

pp. 54-56

Author(s):

Tadao Fujita

Keyword(s):

Crystal Structure ◽

Molecular Modeling ◽

Pancreatic Elastase ◽

X Ray ◽

Sensitive substrates for human leukocyte and porcine pancreatic elastase: A study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases

Analytical Biochemistry ◽

10.1016/0003-2697(79)90043-5 ◽

1979 ◽

Vol 99 (1) ◽

pp. 53-64 ◽

Cited By ~ 172

Author(s):

Mario J. Castillo ◽

Kiichiro Nakajima ◽

Morris Zimmerman ◽

James C. Powers

Keyword(s):

Serine Proteases ◽

Human Leukocyte ◽

Pancreatic Elastase ◽

Porcine Pancreatic Elastase ◽

Leaving Groups

Inhibition of human leukocyte elastase, cathepsin G, chymotrypsin A.alpha., and porcine pancreatic elastase with substituted isobenzofuranones and benzopyrandiones

Biochemistry ◽

10.1021/bi00329a006 ◽

1985 ◽

Vol 24 (8) ◽

pp. 1841-1848 ◽

Cited By ~ 17

Author(s):

Keiji Hemmi ◽

J. Wade Harper ◽

James C. Powers

Keyword(s):

Human Leukocyte ◽

Cathepsin G ◽

Leukocyte Elastase ◽

Pancreatic Elastase ◽