Binding of scorpion neurotoxins to chick embryonic heart cells in culture and relationship to calcium uptake and membrane potential

Biochemistry ◽  
1980 ◽  
Vol 19 (3) ◽  
pp. 457-462 ◽  
Author(s):  
Francois Couraud ◽  
Herve Rochat ◽  
Serge Lissitzky
Keyword(s):  
Membrane Potential ◽  
Calcium Uptake ◽  
Embryonic Heart ◽  
Heart Cells ◽  
Cells In Culture

scholarly journals Intracellular Ca2+ Oscillations, a Potential Pacemaking Mechanism in Early Embryonic Heart Cells

2007 ◽  
Vol 130 (2) ◽  
pp. 133-144 ◽  
Author(s):  
Philipp Sasse ◽  
Jianbao Zhang ◽  
Lars Cleemann ◽  
Martin Morad ◽  
Juergen Hescheler ◽  
...  
Keyword(s):  
Membrane Potential ◽  
Sarcoplasmic Reticulum ◽  
Ryanodine Receptor ◽  
Action Potentials ◽  
Embryonic Heart ◽  
Heart Cells ◽  
Periodic Oscillations ◽  
Mechanical Signals ◽  
Embryonic Cardiomyocytes

Early (E9.5–E11.5) embryonic heart cells beat spontaneously, even though the adult pacemaking mechanisms are not yet fully established. Here we show that in isolated murine early embryonic cardiomyocytes periodic oscillations of cytosolic Ca2+ occur and that these induce contractions. The Ca2+ oscillations originate from the sarcoplasmic reticulum and are dependent on the IP3 and the ryanodine receptor. The Ca2+ oscillations activate the Na+-Ca2+ exchanger, giving rise to subthreshold depolarizations of the membrane potential and/or action potentials. Although early embryonic heart cells are voltage-independent Ca2+ oscillators, the generation of action potentials provides synchronization of the electrical and mechanical signals. Thus, Ca2+ oscillations pace early embryonic heart cells and the ensuing activation of the Na+-Ca2+ exchanger evokes small membrane depolarizations or action potentials.

scholarly journals Accelerated rates of ribosomal RNA synthesis during growth of contracting heart cells in culture

1989 ◽  
Vol 264 (30) ◽  
pp. 18220-18227
Author(s):  
P J McDermott ◽  
L I Rothblum ◽  
S D Smith ◽  
H E Morgan
Keyword(s):  
Ribosomal Rna ◽  
Rna Synthesis ◽  
Heart Cells ◽  
Cells In Culture ◽  
Contracting Heart

scholarly journals Effects of Barium on Mature and Embryonic Heart Cells

1966 ◽  
Vol 18 (5) ◽  
pp. 484-491 ◽  
Author(s):  
Morris Kleinfeld ◽  
Edward Stein ◽  
Clem Tionaytis
Keyword(s):  
Embryonic Heart ◽  
Heart Cells
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