Picomolar Transition State Analogue Inhibitors of Human 5‘-Methylthioadenosine Phosphorylase and X-ray Structure with MT-Immucillin-A†

Biochemistry ◽  
2004 ◽  
Vol 43 (1) ◽  
pp. 9-18 ◽  
Author(s):  
Vipender Singh ◽  
Wuxian Shi ◽  
Gary B. Evans ◽  
Peter C. Tyler ◽  
Richard H. Furneaux ◽  
...  
Keyword(s):  
Transition State ◽  
X Ray ◽  
Methylthioadenosine Phosphorylase ◽  
Transition State Analogue ◽  
Transition State Analogue Inhibitors

Targeting the Polyamine Pathway with Transition-State Analogue Inhibitors of 5‘-Methylthioadenosine Phosphorylase

2004 ◽  
Vol 47 (12) ◽  
pp. 3275-3281 ◽  
Author(s):  
Gary B. Evans ◽  
Richard H. Furneaux ◽  
Vern L. Schramm ◽  
Vipender Singh ◽  
Peter C. Tyler
Keyword(s):  
Transition State ◽  
Methylthioadenosine Phosphorylase ◽  
Transition State Analogue ◽  
Transition State Analogue Inhibitors

scholarly journals Design and Synthesis of Potent “Sulfur-Free” Transition State Analogue Inhibitors of 5′-Methylthioadenosine Nucleosidase and 5′-Methylthioadenosine Phosphorylase

2010 ◽  
Vol 53 (18) ◽  
pp. 6730-6746 ◽  
Author(s):  
Alistair I. Longshaw ◽  
Florian Adanitsch ◽  
Jemy A. Gutierrez ◽  
Gary B. Evans ◽  
Peter C. Tyler ◽  
...  
Keyword(s):  
Transition State ◽  
Design And Synthesis ◽  
Methylthioadenosine Phosphorylase ◽  
Transition State Analogue ◽  
Free Transition ◽  
Transition State Analogue Inhibitors

scholarly journals Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics

2012 ◽  
Vol 20 (17) ◽  
pp. 5181-5187 ◽  
Author(s):  
Keith Clinch ◽  
Gary B. Evans ◽  
Richard F.G. Fröhlich ◽  
Shivali A. Gulab ◽  
Jemy A. Gutierrez ◽  
...  
Keyword(s):  
Transition State ◽  
Methylthioadenosine Phosphorylase ◽  
Transition State Analogue ◽  
Transition State Analogue Inhibitors

Development of transition state analogue inhibitors for N-acetylglycosyltransferases bearing D-psicoor D-tagatofuranose scaffolds

2015 ◽  
Vol 69 (2) ◽  
Author(s):  
Marek Baráth ◽  
Chun-Hung Lin ◽  
Igor Tvaroška ◽  
Ján Hirsch
Keyword(s):  
Transition State ◽  
Optical Rotation ◽  
Enzymatic Reaction ◽  
Biological Assays ◽  
X Ray ◽  
X Ray Crystallography ◽  
Anomeric Configuration ◽  
Transition State Analogue ◽  
Proposed Model ◽  
Transition State Analogue Inhibitors

AbstractNew potential transition state analogue inhibitors for N-acetylglucosyltransferases (GnTs) were synthesised. These compounds based on psico- and tagatofuranose (structure) scaffold contained a 2-thiophenyl-1-O-diethylphosphate moiety mimicking the proposed model of the transition state of the enzymatic reaction catalysed by N-acetylglucosyltransferases. The synthesised compounds as well as their precursors were fully characterised by NMR, optical rotation and mass techniques. Anomeric configuration of tagatofuranose derivatives was confirmed by X-ray crystallography. Two types of potential human glycosyltransferase (GnTs) inhibitors representing donor UDP-GlcNAc, assigned for biological assays on human GnTs, were prepared.

Second Generation Transition State Analogue Inhibitors of Human 5‘-Methylthioadenosine Phosphorylase

2005 ◽  
Vol 48 (14) ◽  
pp. 4679-4689 ◽  
Author(s):  
Gary B. Evans ◽  
Richard H. Furneaux ◽  
Dirk H. Lenz ◽  
Gavin F. Painter ◽  
Vern L. Schramm ◽  
...  
Keyword(s):  
Transition State ◽  
Second Generation ◽  
Methylthioadenosine Phosphorylase ◽  
Transition State Analogue ◽  
Transition State Analogue Inhibitors

scholarly journals Entropy-Driven Binding of Picomolar Transition State Analogue Inhibitors to Human 5′-Methylthioadenosine Phosphorylase

Biochemistry ◽  
2011 ◽  
Vol 50 (47) ◽  
pp. 10408-10417 ◽  
Author(s):  
Rong Guan ◽  
Meng-Chiao Ho ◽  
Michael Brenowitz ◽  
Peter C. Tyler ◽  
Gary B. Evans ◽  
...  
Keyword(s):  
Transition State ◽  
Methylthioadenosine Phosphorylase ◽  
Transition State Analogue ◽  
Transition State Analogue Inhibitors

scholarly journals Crystallization and preliminary x-ray studies of spinach ribulose 1,5-bisphosphate carboxylase/oxygenase complexed with activator and a transition state analogue.

1983 ◽  
Vol 258 (23) ◽  
pp. 14088-14090
Author(s):  
I Andersson ◽  
A C Tjäder ◽  
E Cedergren-Zeppezauer ◽  
C I Brändén
Keyword(s):  
Transition State ◽  
Bisphosphate Carboxylase ◽  
X Ray ◽  
Transition State Analogue
Sign in / Sign up

Export Citation Format

Share Document