X-ray absorption analysis of the active site of Streptomyces antibioticus Tyrosinase upon binding of transition state analogue inhibitors

2007 ◽  
Vol 465 (2) ◽  
pp. 320-327 ◽  
Author(s):  
Luigi Bubacco ◽  
Roberto Spinazze ◽  
Stefano della Longa ◽  
Maurizio Benfatto
Keyword(s):  
Transition State ◽  
Active Site ◽  
Absorption Analysis ◽  
X Ray ◽  
Streptomyces Antibioticus ◽  
Transition State Analogue ◽  
Transition State Analogue Inhibitors ◽  
X Ray Absorption

Development of transition state analogue inhibitors for N-acetylglycosyltransferases bearing D-psicoor D-tagatofuranose scaffolds

2015 ◽  
Vol 69 (2) ◽  
Author(s):  
Marek Baráth ◽  
Chun-Hung Lin ◽  
Igor Tvaroška ◽  
Ján Hirsch
Keyword(s):  
Transition State ◽  
Optical Rotation ◽  
Enzymatic Reaction ◽  
Biological Assays ◽  
X Ray ◽  
X Ray Crystallography ◽  
Anomeric Configuration ◽  
Transition State Analogue ◽  
Proposed Model ◽  
Transition State Analogue Inhibitors

AbstractNew potential transition state analogue inhibitors for N-acetylglucosyltransferases (GnTs) were synthesised. These compounds based on psico- and tagatofuranose (structure) scaffold contained a 2-thiophenyl-1-O-diethylphosphate moiety mimicking the proposed model of the transition state of the enzymatic reaction catalysed by N-acetylglucosyltransferases. The synthesised compounds as well as their precursors were fully characterised by NMR, optical rotation and mass techniques. Anomeric configuration of tagatofuranose derivatives was confirmed by X-ray crystallography. Two types of potential human glycosyltransferase (GnTs) inhibitors representing donor UDP-GlcNAc, assigned for biological assays on human GnTs, were prepared.

Picomolar Transition State Analogue Inhibitors of Human 5‘-Methylthioadenosine Phosphorylase and X-ray Structure with MT-Immucillin-A†

Biochemistry ◽  
2004 ◽  
Vol 43 (1) ◽  
pp. 9-18 ◽  
Author(s):  
Vipender Singh ◽  
Wuxian Shi ◽  
Gary B. Evans ◽  
Peter C. Tyler ◽  
Richard H. Furneaux ◽  
...  
Keyword(s):  
Transition State ◽  
X Ray ◽  
Methylthioadenosine Phosphorylase ◽  
Transition State Analogue ◽  
Transition State Analogue Inhibitors

Electronic structure ofMS(M=Ca,Mg,Fe,Mn): X-ray absorption analysis

2004 ◽  
Vol 69 (13) ◽  
Author(s):  
A. N. Kravtsova ◽  
I. E. Stekhin ◽  
A. V. Soldatov ◽  
X. Liu ◽  
M. E. Fleet
Keyword(s):  
Electronic Structure ◽  
Absorption Analysis ◽  
X Ray ◽  
X Ray Absorption

scholarly journals Transition State Analogue Inhibitors of 5′-Deoxyadenosine/5′-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis

Biochemistry ◽  
2017 ◽  
Vol 56 (38) ◽  
pp. 5090-5098 ◽  
Author(s):  
Hilda A. Namanja-Magliano ◽  
Gary B. Evans ◽  
Rajesh K. Harijan ◽  
Peter C. Tyler ◽  
Vern L. Schramm
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Transition State ◽  
Transition State Analogue ◽  
Transition State Analogue Inhibitors

X-ray absorption analysis of KDP optics

2001 ◽  
Vol 114-116 ◽  
pp. 873-878 ◽  
Author(s):  
A.J. Nelson ◽  
T. van Buuren ◽  
Eric Miller ◽  
T.A. Land ◽  
C. Bostedt ◽  
...  
Keyword(s):  
Absorption Analysis ◽  
X Ray ◽  
X Ray Absorption
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