Mechanistic Studies of the Flavoenzyme Tryptophan 2-Monooxygenase:  Deuterium and15N Kinetic Isotope Effects on Alanine Oxidation by anl-Amino Acid Oxidase†

Erik C. Ralph; Mark A. Anderson; W. Wallace Cleland; Paul F. Fitzpatrick

doi:10.1021/bi061894o

Mechanistic Studies of the Flavoenzyme Tryptophan 2-Monooxygenase: Deuterium and15N Kinetic Isotope Effects on Alanine Oxidation by anl-Amino Acid Oxidase†

Biochemistry ◽

10.1021/bi061894o ◽

2006 ◽

Vol 45 (51) ◽

pp. 15844-15852 ◽

Cited By ~ 32

Author(s):

Erik C. Ralph ◽

Mark A. Anderson ◽

W. Wallace Cleland ◽

Paul F. Fitzpatrick

Keyword(s):

Amino Acid ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Acid Oxidase ◽

Mechanistic Studies ◽

Amino Acid Oxidase ◽

Kinetic Isotope

Contrasting Values of Commitment Factors Measured from Viscosity, pH, and Kinetic Isotope Effects: Evidence for Slow Conformational Changes in theD-Amino Acid Oxidase Reaction

Bioorganic Chemistry ◽

10.1006/bioo.1997.1057 ◽

1997 ◽

Vol 25 (2) ◽

pp. 100-109 ◽

Cited By ~ 1

Author(s):

Paul F. Fitzpatrick ◽

Kevin A. Kurtz ◽

John M. Denu ◽

John F. Emanuele

Keyword(s):

Amino Acid ◽

Conformational Changes ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Acid Oxidase ◽

Amino Acid Oxidase ◽

Kinetic Isotope ◽

Oxidase Reaction

pH and kinetic isotope effects on the reductive half-reaction of D-amino acid oxidase

Biochemistry ◽

10.1021/bi00150a013 ◽

1992 ◽

Vol 31 (35) ◽

pp. 8207-8215 ◽

Cited By ~ 20

Author(s):

John M. Denu ◽

Paul F. Fitzpatrick

Keyword(s):

Amino Acid ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Acid Oxidase ◽

Amino Acid Oxidase ◽

Kinetic Isotope

Intrinsic Primary, Secondary, and Solvent Kinetic Isotope Effects on the Reductive Half-Reaction of D-Amino Acid Oxidase: Evidence against a Concerted Mechanism

Biochemistry ◽

10.1021/bi00179a029 ◽

1994 ◽

Vol 33 (13) ◽

pp. 4001-4007 ◽

Cited By ~ 20

Author(s):

John M. Denu ◽

Paul F. Fitzpatrick

Keyword(s):

Amino Acid ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Acid Oxidase ◽

Amino Acid Oxidase ◽

Concerted Mechanism ◽

Kinetic Isotope

pH and Secondary Kinetic Isotope Effects on the Reaction ofd-Amino Acid Oxidase with Nitroalkane Anions: Evidence for Direct Attack on the Flavin by Carbanions

Journal of the American Chemical Society ◽

10.1021/ja962783n ◽

1997 ◽

Vol 119 (5) ◽

pp. 1155-1156 ◽

Cited By ~ 16

Author(s):

Kevin A. Kurtz ◽

Paul F. Fitzpatrick

Keyword(s):

Amino Acid ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Acid Oxidase ◽

Amino Acid Oxidase ◽

Kinetic Isotope ◽

Direct Attack

pH and kinetic isotope effects on the oxidative half-reaction of D-amino-acid oxidase.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)36573-0 ◽

1994 ◽

Vol 269 (21) ◽

pp. 15054-15059 ◽

Cited By ~ 1

Author(s):

J.M. Denu ◽

P.F. Fitzpatrick

Keyword(s):

Amino Acid ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Acid Oxidase ◽

Amino Acid Oxidase ◽

Kinetic Isotope

pH and kinetic isotope effects in d -amino acid oxidase catalysis.

European Journal of Biochemistry ◽

10.1046/j.1432-1033.2001.02462.x ◽

2001 ◽

Vol 268 (21) ◽

pp. 5504-5520 ◽

Cited By ~ 42

Author(s):

Christopher M. Harris ◽

Loredano Pollegioni ◽

Sandro Ghisla

Keyword(s):

Amino Acid ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Acid Oxidase ◽

Amino Acid Oxidase ◽

Kinetic Isotope

Online Oxygen Kinetic Isotope Effects Using Membrane Inlet Mass Spectrometry Can Differentiate between Oxidases for Mechanistic Studies and Calculation of Their Contributions to Oxygen Consumption in Whole Tissues

Analytical Chemistry ◽

10.1021/ac501086n ◽

2014 ◽

Vol 86 (10) ◽

pp. 5171-5178 ◽

Cited By ~ 8

Author(s):

Mun Hon Cheah ◽

A. Harvey Millar ◽

Ruth C. Myers ◽

David A. Day ◽

Justine Roth ◽

...

Keyword(s):

Mass Spectrometry ◽

Oxygen Consumption ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Mechanistic Studies ◽

Membrane Inlet Mass Spectrometry ◽

Kinetic Isotope

Kinetic isotope effects and their application in the mechanistic studies of some transition-metal-catalyzed reactions

Scientia Sinica Chimica ◽

10.1360/n032015-00254 ◽

2016 ◽

Vol 46 (6) ◽

pp. 573-578 ◽

Cited By ~ 1

Author(s):

Yujing Zhou ◽

Jian-Bo Wang

Keyword(s):

Transition Metal ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Mechanistic Studies ◽

Kinetic Isotope ◽

Transition Metal Catalyzed ◽

Catalyzed Reactions ◽

Metal Catalyzed

Mechanistic studies of the flavoprotein tryptophan 2-monooxygenase. 2. pH and kinetic isotope effects

Biochemistry ◽

10.1021/bi00011a029 ◽

1995 ◽

Vol 34 (11) ◽

pp. 3716-3723 ◽

Cited By ~ 23

Author(s):

John J. Emanuele ◽

Paul F. Fitzpatrick

Keyword(s):

Isotope Effects ◽

Kinetic Isotope Effects ◽

Mechanistic Studies ◽

Kinetic Isotope

(S)-Mandelate Dehydrogenase fromPseudomonas putida: Mechanistic Studies with Alternate Substrates and pH and Kinetic Isotope Effects†

Biochemistry ◽

10.1021/bi990024m ◽

1999 ◽

Vol 38 (18) ◽

pp. 5836-5848 ◽

Cited By ~ 21

Author(s):

Isabelle E. Lehoux ◽

Bharati Mitra

Keyword(s):

Isotope Effects ◽

Kinetic Isotope Effects ◽

Mechanistic Studies ◽

Kinetic Isotope