scholarly journals Reduction of Hydrophilic Ubiquinones by the Flavin in Mitochondrial NADH:Ubiquinone Oxidoreductase (Complex I) and Production of Reactive Oxygen Species†

Biochemistry ◽  
2009 ◽  
Vol 48 (9) ◽  
pp. 2053-2062 ◽  
Author(s):  
Martin S. King ◽  
Mark S. Sharpley ◽  
Judy Hirst
Keyword(s):  
Reactive Oxygen Species ◽  
Complex I ◽  
Reactive Oxygen ◽  
Nadh:Ubiquinone Oxidoreductase ◽  
Oxygen Species

scholarly journals Production of Reactive Oxygen Species by Complex I (NADH:Ubiquinone Oxidoreductase) from Escherichia coli and Comparison to the Enzyme from Mitochondria†

Biochemistry ◽  
2008 ◽  
Vol 47 (12) ◽  
pp. 3964-3971 ◽  
Author(s):  
Daria Esterházy ◽  
Martin S. King ◽  
Gregory Yakovlev ◽  
Judy Hirst
Keyword(s):  
Escherichia Coli ◽  
Reactive Oxygen Species ◽  
Complex I ◽  
Reactive Oxygen ◽  
Nadh:Ubiquinone Oxidoreductase ◽  
Oxygen Species

The production of reactive oxygen species by complex I

2008 ◽  
Vol 36 (5) ◽  
pp. 976-980 ◽  
Author(s):  
Judy Hirst ◽  
Martin S. King ◽  
Kenneth R. Pryde
Keyword(s):  
Reactive Oxygen Species ◽  
Complex I ◽  
Neuromuscular Diseases ◽  
Reactive Oxygen ◽  
Flavin Mononucleotide ◽  
Nadh:Ubiquinone Oxidoreductase ◽  
Oxygen Species ◽  
Quinone Binding ◽  
O2 Reduction ◽  
Reverse Electron Transport

ROS (reactive oxygen species) are considered to be a major cause of cellular oxidative stress, linked to neuromuscular diseases and aging. Complex I (NADH:ubiquinone oxidoreductase) is one of the main contributors to superoxide production by mitochondria, and knowledge of its mechanism of O2 reduction is required for the formulation of causative connections between complex I defects and pathological effects. There is evidence for two distinct (but not mutually exclusive) sites of O2 reduction by complex I. Studies of the isolated enzyme largely support the participation of the reduced flavin mononucleotide in the active site for NADH oxidation, and this mechanism is supported in mitochondria by correlations between the NAD(P)+ potential and O2 reduction. In addition, studies of intact mitochondria or submitochondrial particles have suggested a mechanism involving the quinone-binding site, supported by observations during reverse electron transport and the use of ‘Q-site’ inhibitors. Here, we discuss extant data and models for O2 reduction by complex I. We compare results from the isolated enzyme with results from intact mitochondria, aiming to identify similarities and differences between them and progress towards combining them to form a single, unified picture.

The β-adrenoceptor agonist isoproterenol promotes the activity of respiratory chain complex I and lowers cellular reactive oxygen species in fibroblasts and heart myoblasts

2011 ◽  
Vol 652 (1-3) ◽  
pp. 15-22 ◽  
Author(s):  
Domenico De Rasmo ◽  
Giuliano Gattoni ◽  
Francesco Papa ◽  
Arcangela Santeramo ◽  
Consiglia Pacelli ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Respiratory Chain ◽  
Complex I ◽  
Reactive Oxygen ◽  
Chain Complex ◽  
Oxygen Species ◽  
Respiratory Chain Complex ◽  
Adrenoceptor Agonist ◽  
Cellular Reactive Oxygen Species

scholarly journals The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species

2017 ◽  
Vol 40 (6) ◽  
pp. 583-594.e6 ◽  
Author(s):  
Evan A. Bordt ◽  
Pascaline Clerc ◽  
Brian A. Roelofs ◽  
Andrew J. Saladino ◽  
László Tretter ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Complex I ◽  
Reactive Oxygen ◽  
Mitochondrial Complex I ◽  
Oxygen Species ◽  
Mitochondrial Complex ◽  
Mitochondrial Complex I Inhibitor

scholarly journals Inactivation of the Na+ -translocating NADH:ubiquinone oxidoreductase from Vibrio alginolyticus by reactive oxygen species

2002 ◽  
Vol 269 (4) ◽  
pp. 1287-1292 ◽  
Author(s):  
Julia Steuber ◽  
Michèle Rufibach ◽  
Günter Fritz ◽  
Frank Neese ◽  
Peter Dimroth
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Vibrio Alginolyticus ◽  
Nadh:Ubiquinone Oxidoreductase ◽  
Oxygen Species

Reactive Oxygen Species Production by Escherichia coli Respiratory Complex I

Biochemistry ◽  
2015 ◽  
Vol 54 (18) ◽  
pp. 2799-2801 ◽  
Author(s):  
Klaudia Frick ◽  
Marius Schulte ◽  
Thorsten Friedrich
Keyword(s):  
Escherichia Coli ◽  
Reactive Oxygen Species ◽  
Complex I ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Respiratory Complex ◽  
Respiratory Complex I ◽  
Species Production
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