Tablets of Functionalized Polystyrene Beads Alone and in Combination with Solid Reagents or Catalysts. Preparation and Applications in Parallel Solution and Solid Phase Synthesis†

2003 ◽  
Vol 5 (6) ◽  
pp. 842-850 ◽  
Author(s):  
Thomas Ruhland ◽  
Per Holm ◽  
Kim Andersen
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Parallel Solution ◽  
Polystyrene Beads ◽  
Catalysts Preparation

scholarly journals The Breaking Beads Approach for Photocleavage from Solid Support

2020 ◽  
Author(s):  
yasmeen bakhatan ◽  
Israel Alshanski ◽  
Dana Grunhaus ◽  
Mattan Hurevich
Keyword(s):  
Continuous Flow ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
High Energy ◽  
Solid Support ◽  
Phase Synthesis ◽  
Polystyrene Beads ◽  
Magnetic Stirring ◽  
Photolabile Linkers

Photocleavage from polystyrene beads is a pivotal reaction for solid phase synthesis that relies on photolabile linkers. The photocleavage, usually performed by batch irradiation, suffers from incomplete and slow cleavage. To overcome these issues, continuous flow and high-energy lamps are frequently used, but these setups are hazardous, technically challenging, and expensive. We developed a photocleavage approach that relies on a benchtop LED lamp and magnetic stirring. In this approach, we crush the beads instead of keeping their integrity to increase the yield of photocleavage. This approach proved very efficient for photocleavage of protected oligosaccharides.

Parallel solution- and solid-phase synthesis of spiropyrrolo-Pyrroles as novel neurokinin receptor ligands

2002 ◽  
Vol 12 (21) ◽  
pp. 3073-3076 ◽  
Author(s):  
Konrad H Bleicher ◽  
Yves Wüthrich ◽  
Geo Adam ◽  
Torsten Hoffmann ◽  
Andrew J Sleight
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Receptor Ligands ◽  
Phase Synthesis ◽  
Parallel Solution ◽  
Neurokinin Receptor

Parallel solution- and solid-Phase synthesis of spirohydantoin derivatives as neurokinin-1 receptor ligands

2002 ◽  
Vol 12 (18) ◽  
pp. 2519-2522 ◽  
Author(s):  
Konrad H. Bleicher ◽  
Yves Wüthrich ◽  
Maxime De Boni ◽  
Sabine Kolczewski ◽  
Torsten Hoffmann ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Receptor Ligands ◽  
Phase Synthesis ◽  
Neurokinin 1 Receptor ◽  
Parallel Solution ◽  
Neurokinin 1

Parallel Solution-Phase Synthesis of (Z)-3-(Arylamino)-2,3-dehydroalanine Derivatives and Solid-Phase Synthesis of Fused Pyrimidones.

ChemInform ◽  
2004 ◽  
Vol 35 (38) ◽  
Author(s):  
Petra Cebasek ◽  
Jernej Wagger ◽  
David Bevk ◽  
Renata Jakse ◽  
Jurij Svete ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solution Phase ◽  
Phase Synthesis ◽  
Parallel Solution ◽  
Solution Phase Synthesis

Parallel Solution- and Solid-Phase Synthesis of Spirohydantoin Derivatives as Neurokinin-1 Receptor Ligands.

ChemInform ◽  
2003 ◽  
Vol 34 (3) ◽  
Author(s):  
Konrad H. Bleicher ◽  
Yves Wuethrich ◽  
Maxime De Boni ◽  
Sabine Kolczewski ◽  
Torsten Hoffmann ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Receptor Ligands ◽  
Phase Synthesis ◽  
Neurokinin 1 Receptor ◽  
Parallel Solution ◽  
Neurokinin 1

ChemInform Abstract: Preparation of Small Molecule Libraries for Agrochemical Discovery. Development of Parallel Solution and Solid Phase Synthesis Methods

ChemInform ◽  
2010 ◽  
Vol 32 (28) ◽  
pp. no-no
Author(s):  
Bruce C. Hamper ◽  
Thomas J. Owen ◽  
Kevin D. Jerome ◽  
Angela S. Scates ◽  
Stephen A. Kolodziej ◽  
...  
Keyword(s):  
Small Molecule ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Synthesis Methods ◽  
Phase Synthesis ◽  
Parallel Solution ◽  
Small Molecule Libraries

Parallel Solution-Phase Synthesis of (Z)-3-(Arylamino)-2,3-dehydroalanine Derivatives and Solid-Phase Synthesis of Fused Pyrimidones

2004 ◽  
Vol 6 (3) ◽  
pp. 356-362 ◽  
Author(s):  
Petra Čebašek ◽  
Jernej Wagger ◽  
David Bevk ◽  
Renata Jakše ◽  
Jurij Svete ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solution Phase ◽  
Phase Synthesis ◽  
Parallel Solution ◽  
Solution Phase Synthesis

scholarly journals The Breaking Beads Approach for Photocleavage from Solid Support

2020 ◽  
Author(s):  
yasmeen bakhatan ◽  
Israel Alshanski ◽  
Dana Grunhaus ◽  
Mattan Hurevich
Keyword(s):  
Continuous Flow ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
High Energy ◽  
Solid Support ◽  
Phase Synthesis ◽  
Polystyrene Beads ◽  
Magnetic Stirring ◽  
Photolabile Linkers

Photocleavage from polystyrene beads is a pivotal reaction for solid phase synthesis that relies on photolabile linkers. The photocleavage, usually performed by batch irradiation, suffers from incomplete and slow cleavage. To overcome these issues, continuous flow and high-energy lamps are frequently used, but these setups are hazardous, technically challenging, and expensive. We developed a photocleavage approach that relies on a benchtop LED lamp and magnetic stirring. In this approach, we crush the beads instead of keeping their integrity to increase the yield of photocleavage. This approach proved very efficient for photocleavage of protected oligosaccharides.

Parallel Solution- and Solid-Phase Synthesis of Spiropyrrolo-Pyrroles as Novel Neurokinin Receptor Ligands.

ChemInform ◽  
2003 ◽  
Vol 34 (9) ◽  
Author(s):  
Konrad H. Bleicher ◽  
Yves Wuethrich ◽  
Geo Adam ◽  
Torsten Hoffmann ◽  
Andrew J. Sleight
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Receptor Ligands ◽  
Phase Synthesis ◽  
Parallel Solution ◽  
Neurokinin Receptor
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