Liquid–Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Poorly Water-Soluble Drugs: Implications for Solubility Enhancing Formulations

Grace A. Ilevbare; Lynne S. Taylor

doi:10.1021/cg301679h

Liquid–Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Poorly Water-Soluble Drugs: Implications for Solubility Enhancing Formulations

Crystal Growth & Design ◽

10.1021/cg301679h ◽

2013 ◽

Vol 13 (4) ◽

pp. 1497-1509 ◽

Cited By ~ 165

Author(s):

Grace A. Ilevbare ◽

Lynne S. Taylor

Keyword(s):

Phase Separation ◽

Liquid Phase ◽

Aqueous Solutions ◽

Liquid Phase Separation ◽

Water Soluble ◽

Poorly Water Soluble Drugs ◽

Water Soluble Drugs ◽

Poorly Water Soluble ◽

Liquid Liquid Phase Separation

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Exploiting the Phenomenon of Liquid–Liquid Phase Separation for Enhanced and Sustained Membrane Transport of a Poorly Water-Soluble Drug

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.6b00202 ◽

2016 ◽

Vol 13 (6) ◽

pp. 2059-2069 ◽

Cited By ~ 62

Author(s):

Anura S. Indulkar ◽

Yi Gao ◽

Shweta A. Raina ◽

Geoff G. Z. Zhang ◽

Lynne S. Taylor

Keyword(s):

Phase Separation ◽

Liquid Phase ◽

Membrane Transport ◽

Liquid Phase Separation ◽

Water Soluble ◽

Water Soluble Drug ◽

Poorly Water Soluble ◽

Liquid Liquid Phase Separation ◽

Poorly Water Soluble Drug

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Using Environment-Sensitive Fluorescent Probes to Characterize Liquid-Liquid Phase Separation in Supersaturated Solutions of Poorly Water Soluble Compounds

Pharmaceutical Research ◽

10.1007/s11095-015-1725-z ◽

2015 ◽

Vol 32 (11) ◽

pp. 3660-3673 ◽

Cited By ~ 23

Author(s):

Shweta A. Raina ◽

David E. Alonzo ◽

Geoff G. Z. Zhang ◽

Yi Gao ◽

Lynne S. Taylor

Keyword(s):

Phase Separation ◽

Liquid Phase ◽

Fluorescent Probes ◽

Liquid Phase Separation ◽

Water Soluble ◽

Poorly Water Soluble ◽

Supersaturated Solutions ◽

Liquid Liquid Phase Separation

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Liquid-liquid phase separation in dilute aqueous solutions of surfactants: the effect of added salt

Langmuir ◽

10.1021/la00080a027 ◽

1988 ◽

Vol 4 (2) ◽

pp. 414-418 ◽

Cited By ~ 19

Author(s):

Toyoko Imae ◽

M. Sasaki ◽

A. Abe ◽

S. Ikeda

Keyword(s):

Phase Separation ◽

Liquid Phase ◽

Aqueous Solutions ◽

Liquid Phase Separation ◽

Dilute Aqueous Solutions ◽

Liquid Liquid Phase Separation ◽

Added Salt

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The surface profile of aqueous solutions of an amphiphile near liquid/liquid phase separation probed by ellipsometry

Journal of Physics Condensed Matter ◽

10.1088/0953-8984/8/47/059 ◽

1996 ◽

Vol 8 (47) ◽

pp. 9541-9546 ◽

Cited By ~ 4

Author(s):

Andrea Hirtz ◽

Gerhard H Findenegg

Keyword(s):

Phase Separation ◽

Liquid Phase ◽

Aqueous Solutions ◽

Surface Profile ◽

Liquid Phase Separation ◽

Liquid Liquid Phase Separation

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Thermodynamics of Highly Supersaturated Aqueous Solutions of Poorly Water-Soluble Drugs—Impact of a Second Drug on the Solution Phase Behavior and Implications for Combination Products

Journal of Pharmaceutical Sciences ◽

10.1002/jps.24528 ◽

2015 ◽

Vol 104 (8) ◽

pp. 2583-2593 ◽

Cited By ~ 39

Author(s):

Niraj S. Trasi ◽

Lynne S. Taylor

Keyword(s):

Aqueous Solutions ◽

Phase Behavior ◽

Water Soluble ◽

Solution Phase ◽

Poorly Water Soluble Drugs ◽

Water Soluble Drugs ◽

Poorly Water Soluble

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Quantitative Evaluation of Protein Solubility in Aqueous Solutions by PEG-Induced Liquid–Liquid Phase Separation

Methods in Molecular Biology - Protein Self-Assembly ◽

10.1007/978-1-4939-9678-0_3 ◽

2019 ◽

pp. 39-49

Author(s):

Ying Wang ◽

Ramil F. Latypov

Keyword(s):

Phase Separation ◽

Liquid Phase ◽

Aqueous Solutions ◽

Quantitative Evaluation ◽

Protein Solubility ◽

Liquid Phase Separation ◽

Liquid Liquid Phase Separation

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Protein Phase Behavior in Aqueous Solutions: Crystallization, Liquid-Liquid Phase Separation, Gels, and Aggregates

Biophysical Journal ◽

10.1529/biophysj.107.116152 ◽

2008 ◽

Vol 94 (2) ◽

pp. 570-583 ◽

Cited By ~ 151

Author(s):

André C. Dumetz ◽

Aaron M. Chockla ◽

Eric W. Kaler ◽

Abraham M. Lenhoff

Keyword(s):

Phase Separation ◽

Liquid Phase ◽

Aqueous Solutions ◽

Phase Behavior ◽

Liquid Phase Separation ◽

Liquid Liquid Phase Separation

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Trends in the Precipitation and Crystallization Behavior of Supersaturated Aqueous Solutions of Poorly Water-Soluble Drugs Assessed Using Synchrotron Radiation

Journal of Pharmaceutical Sciences ◽

10.1002/jps.24423 ◽

2015 ◽

Vol 104 (6) ◽

pp. 1981-1992 ◽

Cited By ~ 48

Author(s):

Shweta A. Raina ◽

Bernard Van Eerdenbrugh ◽

David E. Alonzo ◽

Huaping Mo ◽

Geoff G.Z. Zhang ◽

...

Keyword(s):

Synchrotron Radiation ◽

Aqueous Solutions ◽

Crystallization Behavior ◽

Water Soluble ◽

Poorly Water Soluble Drugs ◽

Water Soluble Drugs ◽

Poorly Water Soluble

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Liquid–Liquid Phase Separation: A Widespread and Versatile Way to Organize Aqueous Solutions

The Journal of Physical Chemistry B ◽

10.1021/acs.jpcb.1c08831 ◽

2021 ◽

Vol 125 (45) ◽

pp. 12399-12400

Author(s):

Christine D. Keating ◽

Rohit V. Pappu

Keyword(s):

Phase Separation ◽

Liquid Phase ◽

Aqueous Solutions ◽

Liquid Phase Separation ◽

Liquid Liquid Phase Separation

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Liquid–Liquid Phase Separation: A Widespread and Versatile Way to Organize Aqueous Solutions

The Journal of Physical Chemistry Letters ◽

10.1021/acs.jpclett.1c03352 ◽

2021 ◽

Vol 12 (45) ◽

pp. 10994-10995

Author(s):

Christine D. Keating ◽

Rohit V. Pappu

Keyword(s):

Phase Separation ◽

Liquid Phase ◽

Aqueous Solutions ◽

Liquid Phase Separation ◽

Liquid Liquid Phase Separation

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