A Comparative Mechanistic Study of the Reversible Binding of NO to a Water-Soluble Octa-Cationic FeIIIPorphyrin Complex

2006 ◽  
Vol 45 (3) ◽  
pp. 1326-1337 ◽  
Author(s):  
Joo-Eun Jee ◽  
Maria Wolak ◽  
Domenico Balbinot ◽  
Norbert Jux ◽  
Achim Zahl ◽  
...  
Keyword(s):  
Water Soluble ◽  
Mechanistic Study ◽  
Reversible Binding

scholarly journals High-throughput preparation of radioprotective polymers via Hantzsch’s reaction for in vivo X-ray damage determination

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Guoqiang Liu ◽  
Yuan Zeng ◽  
Tong Lv ◽  
Tengfei Mao ◽  
Yen Wei ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
High Throughput ◽  
Water Soluble ◽  
Mechanistic Study ◽  
Initial Attempt ◽  
Water Soluble Polymer ◽  
X Ray ◽  
In Vivo Experiments ◽  
Acute Injuries

AbstractRadioprotectors for acute injuries caused by large doses of ionizing radiation are vital to national security, public health and future development of humankind. Here, we develop a strategy to explore safe and efficient radioprotectors by combining Hantzsch’s reaction, high-throughput methods and polymer chemistry. A water-soluble polymer with low-cytotoxicity and an excellent anti-radiation capability has been achieved. In in vivo experiments, this polymer is even better than amifostine, which is the only approved radioprotector for clinical applications, in effectively protecting zebrafish embryos from fatally large doses of ionizing radiation (80 Gy X-ray). A mechanistic study also reveals that the radioprotective ability of this polymer originates from its ability to efficiently prevent DNA damage due to high doses of radiation. This is an initial attempt to explore polymer radioprotectors via a multi-component reaction. It allows exploiting functional polymers and provides the underlying insights to guide the design of radioprotective polymers.

Mechanistic study of a manganese porphyrin catalyst for on-demand production of chlorine dioxide in water

2015 ◽  
Vol 19 (01-03) ◽  
pp. 492-499 ◽  
Author(s):  
Scott D. Hicks ◽  
Silei Xiong ◽  
Curt J. Bougher ◽  
Grigori A. Medvedev ◽  
James Caruthers ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Chlorine Dioxide ◽  
Transfer Reaction ◽  
Water Soluble ◽  
Reaction Pathways ◽  
Mechanistic Study ◽  
Manganese Porphyrin ◽  
Oxygen Atom Transfer ◽  
On Demand ◽  
Proton Coupled Electron Transfer

A water-soluble manganese porphyrin complex was examined for the catalytic formation of chlorine dioxide from chlorite under ambient temperature at pH 5.00 and 6.90. Quantitative kinetic modeling allowed for the deduction of a mechanism that accounts for all experimental observations. Catalysis is initiated via an OAT (Oxygen Atom Transfer) reaction resulting in formation of a putative manganese(V) oxo species, which undergoes ET (Electron Transfer) with chlorite to form chlorine dioxide. As chlorine dioxide accumulates in solution, chlorite consumption slows down and ClO 2 reaches a maximum as the system reaches equilibrium. In phosphate buffer at pH 6.90, manganese(IV) oxo accumulates and its reaction with ClO 2 gives ClO 3-. However, at pH 5.00 acetate buffer proton coupled electron transfer (PCET) from chlorite to manganese(IV) oxo is fast and irreversible leading to chlorate formation only via the putative manganese(V) oxo species. These differences underscore how PCET rates affect reaction pathways and mechanism. The ClO 2 product can be collected from the aqueous reaction mixture via purging with an inert gas, allowing for the preparation of chlorine dioxide on-demand.

Synthesis and mechanistic study of stable water-soluble noble metal nanostructures

2011 ◽  
Vol 22 (28) ◽  
pp. 285601 ◽  
Author(s):  
Ling-Jian Cai ◽  
Min Wang ◽  
Yang Hu ◽  
Dong-Jin Qian ◽  
Meng Chen
Keyword(s):  
Noble Metal ◽  
Water Soluble ◽  
Mechanistic Study ◽  
Metal Nanostructures ◽  
Noble Metal Nanostructures

Reversible Binding of C60 to an Anthracene Bearing a Dendritic Poly(amidoamine) Substituent to give a Water-Soluble Fullerodendrimer

2002 ◽  
Vol 114 (5) ◽  
pp. 845-847 ◽  
Author(s):  
Yutaka Takaguchi ◽  
Tomoyuki Tajima ◽  
Kazuchika Ohta ◽  
Jiro Motoyoshiya ◽  
Hiromu Aoyama ◽  
...  
Keyword(s):  
Water Soluble ◽  
Reversible Binding

A mechanistic study of the interaction of water-soluble borate glass with apatite-bound heterocyclic nitrogen-containing bisphosphonates

2016 ◽  
Vol 31 ◽  
pp. 339-347 ◽  
Author(s):  
Chandrani Pramanik ◽  
Parveen Sood ◽  
Li-na Niu ◽  
He Yuan ◽  
Sushanta Ghoshal ◽  
...  
Keyword(s):  
Borate Glass ◽  
Water Soluble ◽  
Mechanistic Study ◽  
Heterocyclic Nitrogen
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