Displacement of Nuclear Halogen Atoms in Hindered Aryl Ketones by the Action of Grignard Reagents

1954 ◽  
Vol 76 (20) ◽  
pp. 5119-5121
Author(s):  
Reynold C. Fuson ◽  
William S. Friedlander ◽  
George W. Parshall
Keyword(s):  
Grignard Reagents ◽  
Halogen Atoms ◽  
Aryl Ketones

Chemoselective Synthesis of Aryl Ketones from Amides and Grignard Reagents via C(O)–N Bond Cleavage under Catalyst-Free Conditions

2019 ◽  
Vol 84 (18) ◽  
pp. 11823-11838 ◽  
Author(s):  
Popuri Sureshbabu ◽  
Sadaf Azeez ◽  
Nalluchamy Muniyappan ◽  
Shahulhameed Sabiah ◽  
Jeyakumar Kandasamy
Keyword(s):  
Bond Cleavage ◽  
Grignard Reagents ◽  
Catalyst Free ◽  
Chemoselective Synthesis ◽  
Aryl Ketones

The Formation of Ketones by a Reaction Equivalent to R-+R′COCH2+→R′COCH2R

1990 ◽  
Vol 43 (1) ◽  
pp. 133 ◽  
Author(s):  
AR Katritzky ◽  
L Wrobel ◽  
GP Savage ◽  
M Deyrupdrewniak
Keyword(s):  
Grignard Reagents ◽  
Aryl Ketones ◽  
General Method

A general method has been developed for the overall transformation of α- bromo ketones to α-alkyl or α-aryl ketones , with benzotriazole being used as a synthetic auxiliary. α- Benzotriazolyl ketones , when converted into their phenylhydrazones, reacted smoothly with alkyl and aryl Grignard reagents, which displaced benzotriazolate, to give the corresponding α-alkyl or α-aryl hydrazones. In some cases, these hydrolysed directly to the α-alkyl or α-aryl ketones. In each case, the product was treated with 2,4-dinitrophenylhydrazine to isolate the target ketones as the corresponding 2,4-dinitrophenylhydrazones.

scholarly journals Addition of Grignard Reagents to Aryl Acid Chlorides: An Efficient Synthesis of Aryl Ketones.

ChemInform ◽  
2006 ◽  
Vol 37 (17) ◽  
Author(s):  
Xiao-jun Wang ◽  
Li Zhang ◽  
Xiufeng Sun ◽  
Yibo Xu ◽  
Dhileepkumar Krishnamurthy ◽  
...  
Keyword(s):  
Grignard Reagents ◽  
Acid Chlorides ◽  
Efficient Synthesis ◽  
Aryl Ketones

Addition of Grignard Reagents to Aryl Acid Chlorides:  An Efficient Synthesis of Aryl Ketones

2005 ◽  
Vol 7 (25) ◽  
pp. 5593-5595 ◽  
Author(s):  
Xiao-jun Wang ◽  
Li Zhang ◽  
Xiufeng Sun ◽  
Yibo Xu ◽  
Dhileepkumar Krishnamurthy ◽  
...  
Keyword(s):  
Grignard Reagents ◽  
Acid Chlorides ◽  
Efficient Synthesis ◽  
Aryl Ketones
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