scholarly journals Electrocatalytic O2-Reduction by Synthetic Cytochrome c Oxidase Mimics: Identification of a “Bridging Peroxo” Intermediate Involved in Facile 4e–/4H+ O2-Reduction

2015 ◽  
Vol 137 (40) ◽  
pp. 12897-12905 ◽  
Author(s):  
Sudipta Chatterjee ◽  
Kushal Sengupta ◽  
Shabnam Hematian ◽  
Kenneth D. Karlin ◽  
Abhishek Dey
Keyword(s):  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
O2 Reduction ◽  
Peroxo Intermediate

scholarly journals Tracing the Pathways of Waters and Protons in Photosystem II and Cytochrome c Oxidase

Inorganics ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 14 ◽  
Author(s):  
Divya Kaur ◽  
Xiuhong Cai ◽  
Umesh Khaniya ◽  
Yingying Zhang ◽  
Junjun Mao ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Photosystem Ii ◽  
Cytochrome C Oxidase ◽  
Active Sites ◽  
Proton Pumping ◽  
Oxygen Evolving Complex ◽  
Additional Energy ◽  
Redox Active ◽  
O2 Reduction ◽  
Oxygen Evolving

Photosystem II (PSII) uses water as the terminal electron donor, producing oxygen in the Mn4CaO5 oxygen evolving complex (OEC), while cytochrome c oxidase (CcO) reduces O2 to water in its heme–Cu binuclear center (BNC). Each protein is oriented in the membrane to add to the proton gradient. The OEC, which releases protons, is located near the P-side (positive, at low-pH) of the membrane. In contrast, the BNC is in the middle of CcO, so the protons needed for O2 reduction must be transferred from the N-side (negative, at high pH). In addition, CcO pumps protons from N- to P-side, coupled to the O2 reduction chemistry, to store additional energy. Thus, proton transfers are directly coupled to the OEC and BNC redox chemistry, as well as needed for CcO proton pumping. The simulations that study the changes in proton affinity of the redox active sites and the surrounding protein at different states of the reaction cycle, as well as the changes in hydration that modulate proton transfer paths, are described.

Reaction mechanism and phospholipid structures of bovine heart cytochrome c oxidase

2005 ◽  
Vol 33 (5) ◽  
pp. 934-937 ◽  
Author(s):  
S. Yoshikawa
Keyword(s):  
Hydrogen Bond ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Hydrogen Bond Network ◽  
X Ray ◽  
Bovine Heart ◽  
O2 Reduction ◽  
Bond Network ◽  
Electron Reduction ◽  
Enzyme Functions

Bovine heart cytochrome c oxidase is a large multi-component membrane protein containing several phospholipids. X-ray structures of this enzyme at high resolution, determined recently, show a trigonal planar structure of CuB site in the O2 reduction site, which could contribute critically to the four-electron reduction of O2 bound at haem a3, and a hydrogen bond network, through which the proton pump is driven by haem a. The possible roles of phospholipids in the enzyme functions are discussed.

O2 Reduction by Biosynthetic Models of Cytochrome c Oxidase: Insights into Role of Proton Transfer Residues from Perturbed Active Sites Models of CcO

ACS Catalysis ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. 8915-8924 ◽  
Author(s):  
Sohini Mukherjee ◽  
Manjistha Mukherjee ◽  
Arnab Mukherjee ◽  
Ambika Bhagi-Damodaran ◽  
Yi Lu ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Proton Transfer ◽  
Cytochrome C Oxidase ◽  
Active Sites ◽  
O2 Reduction

Stepwise Binding of Two Azide Ions to the O2-reduction Site of Bovine Heart Cytochrome c Oxidase Shown by Resonance Raman Analyses

2015 ◽  
Vol 44 (8) ◽  
pp. 1142-1144 ◽  
Author(s):  
Masahide Hikita ◽  
Akima Yamamoto ◽  
Kyoko Shinzawa-Itoh ◽  
Takashi Ogura ◽  
Shinya Yoshikawa
Keyword(s):  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Resonance Raman ◽  
Bovine Heart ◽  
O2 Reduction

scholarly journals The O2 reduction and proton pumping gate mechanisms of bovine heart cytochrome c oxidase

2010 ◽  
Vol 1797 ◽  
pp. 102-103 ◽  
Author(s):  
Kazumasa Muramoto ◽  
Kazuhiro Ohta ◽  
Kyoko Shinzawa-Itoh ◽  
Eiki Yamashita ◽  
Tomitake Tsukihara ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Proton Pumping ◽  
Bovine Heart ◽  
O2 Reduction

scholarly journals A peroxide bridge between Fe and Cu ions in the O2 reduction site of fully oxidized cytochrome c oxidase could suppress the proton pump

2009 ◽  
Vol 106 (7) ◽  
pp. 2165-2169 ◽  
Author(s):  
H. Aoyama ◽  
K. Muramoto ◽  
K. Shinzawa-Itoh ◽  
K. Hirata ◽  
E. Yamashita ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Proton Pump ◽  
O2 Reduction ◽  
Cu Ions
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