Influenza Virus Neuraminidase Inhibitory Activity of Phlorotannins from the Edible Brown AlgaEcklonia cava

2011 ◽  
Vol 59 (12) ◽  
pp. 6467-6473 ◽  
Author(s):  
Young Bae Ryu ◽  
Hyung Jae Jeong ◽  
So Young Yoon ◽  
Ji-Young Park ◽  
Young Min Kim ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Inhibitory Activity ◽  
Influenza Virus Neuraminidase

scholarly journals Fcγ Receptors Contribute to the Antiviral Properties of Influenza Virus Neuraminidase-Specific Antibodies

mBio ◽  
2019 ◽  
Vol 10 (5) ◽  
Author(s):  
E. R. Job ◽  
T. Ysenbaert ◽  
A. Smet ◽  
A. Van Hecke ◽  
L. Meuris ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Inhibitory Activity ◽  
Influenza Viruses ◽  
Chimeric Mouse ◽  
Next Generation ◽  
Fcγ Receptors ◽  
Viral Control ◽  
Specific Antibodies ◽  
Influenza Virus Neuraminidase

ABSTRACT Influenza virus neuraminidase (NA) has been under intense study recently as a vaccine antigen, yet there remain unanswered questions regarding the immune response directed toward NA. Antibodies (Abs) that can inhibit NA activity have been shown to aid in the control of disease caused by influenza virus infection in humans and animal models, yet how and if interactions between the Fc portion of anti-NA Abs and Fcγ receptors (FcγR) contribute to protection has not yet been extensively studied. Herein, we show that poly- and monoclonal anti-NA IgG antibodies with NA inhibitory activity can control A(H1N1)pdm09 infection in the absence of FcγRs, but FcγR interaction aided in viral clearance from the lungs. In contrast, a mouse-human chimeric anti-NA IgG1 that was incapable of mediating NA inhibition (NI) solely relied on FcγR interaction to protect transgenic mice (with a humanized FcγR compartment) against A(H1N1)pdm09 infection. As such, this study suggests that NA-specific antibodies contribute to protection against influenza A virus infection even in the absence of NI activity and supports protection through multiple effector mechanisms. IMPORTANCE There is a pressing need for next-generation influenza vaccine strategies that are better able to manage antigenic drift and the cocirculation of multiple drift variants and that consistently improve vaccine effectiveness. Influenza virus NA is a key target antigen as a component of a next-generation vaccine in the influenza field, with evidence for a role in protective immunity in humans. However, mechanisms of protection provided by antibodies directed to NA remain largely unexplored. Herein, we show that antibody Fc interaction with Fcγ receptors (FcγRs) expressed on effector cells contributes to viral control in a murine model of influenza. Importantly, a chimeric mouse-human IgG1 with no direct antiviral activity was demonstrated to solely rely on FcγRs to protect mice from disease. Therefore, antibodies without NA enzymatic inhibitory activity may also play a role in controlling influenza viruses and should be of consideration when designing NA-based vaccines and assessing immunogenicity.

Docking and 3D QSAR study of thiourea analogs as potent inhibitors of influenza virus neuraminidase

2010 ◽  
Vol 16 (12) ◽  
pp. 1809-1818 ◽  
Author(s):  
Jiaying Sun ◽  
Shaoxi Cai ◽  
Hu Mei ◽  
Jian Li ◽  
Ning Yan ◽  
...  
Keyword(s):  
Influenza Virus ◽  
3D Qsar ◽  
Qsar Study ◽  
Influenza Virus Neuraminidase

Difluorosialic acids, potent novel influenza virus neuraminidase inhibitors, induce fewer drug resistance-associated neuraminidase mutations than does oseltamivir

2015 ◽  
Vol 210 ◽  
pp. 126-132 ◽  
Author(s):  
S.-H. Sheldon Tai ◽  
Olga Agafitei ◽  
Zhizeng Gao ◽  
Richard Liggins ◽  
Martin Petric ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Influenza Virus ◽  
Neuraminidase Inhibitors ◽  
Influenza Virus Neuraminidase

scholarly journals Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Yan Wu ◽  
Guangrong Qin ◽  
Feng Gao ◽  
Yue Liu ◽  
Christopher J. Vavricka ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Inhibitor Binding ◽  
Influenza Virus Neuraminidase

scholarly journals Inhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus

2017 ◽  
Vol Volume 12 ◽  
pp. 5733-5743 ◽  
Author(s):  
Yinghua Li ◽  
Zhengfang Lin ◽  
Min Guo ◽  
Yu Xia ◽  
Mingqi Zhao ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Inhibitory Activity ◽  
H1n1 Influenza ◽  
Selenium Nanoparticles ◽  
H1n1 Influenza Virus

Antigenic and biological characterization of influenza virus neuraminidase (N2) with monoclonal antibodies

Virology ◽  
1984 ◽  
Vol 135 (1) ◽  
pp. 30-42 ◽  
Author(s):  
R.G. Webster ◽  
L.E. Brown ◽  
W.G. Laver
Keyword(s):  
Influenza Virus ◽  
Monoclonal Antibodies ◽  
Biological Characterization ◽  
Influenza Virus Neuraminidase

Crystal Structures of Influenza Virus Neuraminidase Complexed with Monoclonal Antibody Fab Fragments

1990 ◽  
pp. 49-60
Author(s):  
W. Graeme Laver ◽  
Gillian M. Air ◽  
Ming Luo ◽  
A. Portner ◽  
S.D. Thompson ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Influenza Virus ◽  
Crystal Structures ◽  
Fab Fragments ◽  
Influenza Virus Neuraminidase
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