scholarly journals Ankaflavin and Monascin Regulate Endothelial Adhesion Molecules and Endothelial NO Synthase (eNOS) Expression Induced by Tumor Necrosis Factor-α (TNF-α) in Human Umbilical Vein Endothelial Cells (HUVECs)

2012 ◽  
Vol 60 (7) ◽  
pp. 1666-1672 ◽  
Author(s):  
Wei-Hsuan Hsu ◽  
Bao-Hong Lee ◽  
I-Jen Lu ◽  
Tzu-Ming Pan
Keyword(s):  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Umbilical Vein ◽  
No Synthase ◽  
Enos Expression ◽  
Tnf Α ◽  
Endothelial Adhesion Molecules ◽  
Umbilical Vein Endothelial Cells ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Baboon fetal arterial endothelial cells are more responsive to challenge by tumor necrosis factor α (TNF-α) than baboon fetal umbilical vein endothelial cells

2010 ◽  
Vol 212 (2) ◽  
pp. 701-703 ◽  
Author(s):  
A. Cerbulo-Vazquez ◽  
M. Zavala ◽  
G.A. Perez-Palacios ◽  
S.L. Jenkins ◽  
Luis D. Giavedoni ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Umbilical Vein ◽  
Tnf Α ◽  
Umbilical Vein Endothelial Cells ◽  
Factor Α ◽  
Arterial Endothelial Cells ◽  
Necrosis Factor

Activation of p42mapkin human umbilical vein endothelial cells by interleukin-1α and tumor necrosis factor-α

1998 ◽  
Vol 274 (3) ◽  
pp. C789-C798 ◽  
Author(s):  
Michael J. May ◽  
Caroline P. D. Wheeler-Jones ◽  
Rebecca A. Houliston ◽  
Jeremy D. Pearson
Keyword(s):  
Endothelial Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Umbilical Vein ◽  
Tnf Α ◽  
Interleukin 1Α ◽  
Umbilical Vein Endothelial Cells ◽  
Factor Α ◽  
Necrosis Factor

Work from this and other laboratories has identified a role for protein tyrosine kinases in interleukin-1α (IL-1α)- and tumor necrosis factor-α (TNF-α)-induced responses in endothelial cells. In this study, we show that activation of human umbilical vein endothelial cells (HUVEC) by IL-1α leads to increased tyrosine phosphorylation of several proteins including one with a molecular mass of ∼42 kDa. This protein was identified as p42mapkby Western blot analysis. Tyrosine phosphorylation and catalytic activation of p42mapkby IL-1α was transient, reaching maximal levels after 30 min and returning to basal levels by 120–300 min. Activation of p42mapkin HUVEC was also observed in response to TNF-α or to the protein kinase C (PKC)-activating phorbol ester phorbol 12-myristate 13-acetate (PMA). Pretreatment of HUVEC with IL-1α or TNF-α prevented reactivation of p42mapkby either cytokine but did not affect subsequent activation in response to PMA. Activation of p42mapkby PMA was significantly reduced by the PKC inhibitor Ro-31-8220 and completely inhibited by the protein tyrosine kinase inhibitor genistein. Genistein, but not Ro-31-8220, attenuated IL-1α- and TNF-α-induced p42mapkactivation. Taken together, the results of this study demonstrate 1) that p42mapkis transiently activated in HUVEC by IL-1α and TNF-α, 2) that this activation is PKC independent, and 3) that a genistein-inhibitable tyrosine kinase may be an upstream regulator of cytokine-induced p42mapkactivation in human endothelium.

Leonurine protects against tumor necrosis factor-α-mediated inflammation in human umbilical vein endothelial cells

2012 ◽  
Vol 222 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Xinhua Liu ◽  
Lilong Pan ◽  
Xianli Wang ◽  
Qihai Gong ◽  
Yi Zhun Zhu
Keyword(s):  
Endothelial Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Umbilical Vein ◽  
Human Umbilical Vein ◽  
Umbilical Vein Endothelial Cells ◽  
Factor Α ◽  
Necrosis Factor

Tumor Necrosis Factor-α Upregulates Angiopoietin-2 in Human Umbilical Vein Endothelial Cells

2000 ◽  
Vol 269 (2) ◽  
pp. 361-365 ◽  
Author(s):  
Injune Kim ◽  
Ji-Hye Kim ◽  
Young Shin Ryu ◽  
Mingzhu Liu ◽  
Gou Young Koh
Keyword(s):  
Endothelial Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Umbilical Vein ◽  
Human Umbilical Vein ◽  
Umbilical Vein Endothelial Cells ◽  
Factor Α ◽  
Angiopoietin 2 ◽  
Necrosis Factor
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