1,2,3-Trisubstituted cyclopropanes as conformationally restricted peptide isosteres: application to the design and synthesis of novel renin inhibitors

Design And Synthesis ◽

Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogs of angiotensinogen

Journal of Medicinal Chemistry ◽

10.1021/jm00397a003 ◽

1988 ◽

Vol 31 (2) ◽

pp. 284-295 ◽

Cited By ~ 43

Author(s):

Hing L. Sham ◽

Giorgio Bolis ◽

Herman H. Stein ◽

Stephen W. Fesik ◽

Patrick A. Marcotte ◽

...

Keyword(s):

Renin Inhibitors ◽

Conformationally Restricted Analogs

Design And Synthesis ◽

New Class ◽

Conformationally restricted peptide isosteres. 2.1 Synthesis and in vitro potency of dipeptide renin inhibitors employing a 2-alkylsulfonyl-3-phenylcyclopropane carboxamide as a P3 amino acid replacement

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(00)80522-3 ◽

1992 ◽

Vol 2 (11) ◽

pp. 1405-1410 ◽

Cited By ~ 9

Author(s):

William R. Baker ◽

Hwan-Soo Jae ◽

Stephen R. Martin ◽

Stephen L. Condon ◽

Herman H. Stein ◽

...

Keyword(s):

Amino Acid ◽

Amino Acid Replacement ◽

Renin Inhibitors ◽

Cyclopropanes as conformationally restricted peptide isosteres. Design and synthesis of novel collagenase inhibitors

Tetrahedron ◽

10.1016/s0040-4020(01)90212-1 ◽

1993 ◽

Vol 49 (17) ◽

pp. 3521-3532 ◽

Cited By ~ 41

Author(s):

Stephen F. Martin ◽

Christopher J. Oalmann ◽

Spiros Liras

Keyword(s):

Design And Synthesis ◽

ChemInform Abstract: Cyclopropanes as Conformationally Restricted Peptide Isosteres. Design and Synthesis of Novel Collagenase Inhibitors.

ChemInform ◽

10.1002/chin.199334255 ◽

2010 ◽

Vol 24 (34) ◽

pp. no-no

Author(s):

S. F. MARTIN ◽

C. J. OALMANN ◽

S. LIRAS

Keyword(s):

Design And Synthesis ◽

Design and synthesis of conformationally restricted renin inhibitors

Peptides ◽

10.1007/978-94-011-2264-1_330 ◽

1992 ◽

pp. 816-817 ◽

Cited By ~ 1

Author(s):

C. E. Brotherton-Pleiss ◽

S. R. Newman ◽

L. D. Waterbury ◽

M. S. Schwartzberg

Keyword(s):

Renin Inhibitors ◽

Design and synthesis of conformationally restricted phospholipids as phospholipase A2 inhibitors

Journal of Cellular Biochemistry ◽

10.1002/jcb.240400313 ◽

1989 ◽

Vol 40 (3) ◽

pp. 371-386 ◽

Cited By ~ 11

Author(s):

R. L. Magolda ◽

W. Galbraith

Keyword(s):

Phospholipase A2 ◽

Design And Synthesis ◽

Phospholipase A2 Inhibitors

Design and synthesis of potent macrocyclic renin inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.10.140 ◽

2011 ◽

Vol 21 (1) ◽

pp. 358-362 ◽

Cited By ~ 14

Author(s):

Christian Sund ◽

Oscar Belda ◽

Daniel Wiktelius ◽

Christer Sahlberg ◽

Lotta Vrang ◽

...

Keyword(s):

Renin Inhibitors ◽

Design and Synthesis of Side-Chain Conformationally Restricted Phenylalanines and Their Use for Structure-Activity Studies on Tachykinin NK-1 Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm00037a009 ◽

1994 ◽

Vol 37 (11) ◽

pp. 1586-1601 ◽

Cited By ~ 55

Author(s):

Hubert Josien ◽

Solange Lavielle ◽

Alie Brunissen ◽

Monique Saffroy ◽

Yvette Torrens ◽

...

Keyword(s):

Side Chain ◽

Design And Synthesis ◽

Structure Activity

ChemInform Abstract: Design and Synthesis of Novel Conformationally Restricted HIV Protease Inhibitors.

ChemInform ◽

10.1002/chin.199916101 ◽

2010 ◽

Vol 30 (16) ◽

pp. no-no

Author(s):

Francesco G. Salituro ◽

ET AL. ET AL.

Keyword(s):

Protease Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Design and synthesis of potent, isoxazole-containing renin inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.03.014 ◽

2012 ◽

Vol 22 (8) ◽

pp. 2670-2674 ◽

Cited By ~ 7

Author(s):

Pierre-André Fournier ◽

Mélissa Arbour ◽

Elizabeth Cauchon ◽

Austin Chen ◽

Amandine Chefson ◽

...

Keyword(s):

Renin Inhibitors ◽