Synthesis of substituted 7,12-dihydropyrido[3,2-b:5,4-b']diindoles: rigid planar benzodiazepine receptor ligands with inverse agonist/antagonist properties

Journal of Medicinal Chemistry ◽

10.1021/jm00171a015 ◽

1990 ◽

Vol 33 (9) ◽

pp. 2412-2420 ◽

Author(s):

Mark L. Trudell ◽

Sherry L. Lifer ◽

Yun Chou Tan ◽

Michael J. Martin ◽

Li Deng ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Inverse Agonist ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands

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Benzodiazepine receptor ligands. 8: Synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: High affinity ligands endowed with inverse-agonist pharmacological efficacy

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2005.08.058 ◽

2006 ◽

Vol 14 (3) ◽

pp. 758-775 ◽

Author(s):

Gabriella Guerrini ◽

Annarella Costanzo ◽

Giovanna Ciciani ◽

Fabrizio Bruni ◽

Silvia Selleri ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Inverse Agonist ◽

Receptor Ligands ◽

Affinity Ligands ◽

Benzodiazepine Receptor Ligands ◽

High Affinity ◽

Pharmacological Evaluation

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ChemInform Abstract: Synthesis of Substituted 7,12-Dihydropyrido(3,2-b:5,4-b′)diindoles: Rigid Planar Benzodiazepine Receptor Ligands with Inverse Agonist/ Antagonist Properties.

10.1002/chin.199108210 ◽

2010 ◽

Vol 22 (8) ◽

pp. no-no

Author(s):

M. L. TRUDELL ◽

S. L. LIFER ◽

Y.-C. TAN ◽

M. J. MARTIN ◽

L. DENG ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Inverse Agonist ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands

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Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl–2 inhibitor HA14–1

Zeitschrift für Gastroenterologie ◽

10.1055/s-2004-831695 ◽

2004 ◽

Vol 42 (08) ◽

Author(s):

A Sutter ◽

K Maaser ◽

P Grabowski ◽

M Höpfner ◽

A Krahn ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Cell Cycle Arrest ◽

Benzodiazepine Receptor ◽

Carcinoma Cells ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

Cycle Arrest ◽

Human Hepatocellular Carcinoma Cells

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Benzodiazepine Receptor Ligands, Memory and Information Processing

10.1007/978-3-642-73288-1 ◽

1988 ◽

Keyword(s):

Information Processing ◽

Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands

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Benzodiazepine receptor ligands and sexual behavior in the male rat: The role of GABAergic mechanisms

Pharmacology Biochemistry and Behavior ◽

10.1016/0091-3057(91)90242-t ◽

1991 ◽

Vol 38 (4) ◽

pp. 781-788 ◽

Author(s):

Anders Ågmo ◽

Hilda Fernández

Keyword(s):

Sexual Behavior ◽

Benzodiazepine Receptor ◽

Male Rat ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands

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Specific high-affinity binding of peripheral benzodiazepine receptor ligands to brain tumors in rat and man

Cancer ◽

10.1002/1097-0142(19900101)65:1<93::aid-cncr2820650120>3.0.co;2-1 ◽

1990 ◽

Vol 65 (1) ◽

pp. 93-97 ◽

Author(s):

Keith L. Black ◽

Kiyonobu Ikezaki ◽

Emily Santori ◽

Donald P. Becker ◽

Harry V. Vinters

Keyword(s):

Brain Tumors ◽

Benzodiazepine Receptor ◽

Affinity Binding ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

High Affinity Binding ◽

Benzodiazepine Receptor Ligands ◽

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Selective changes in the in vivo effects of benzodiazepine receptor ligands after chemical kindling with FG 7142

Neuropharmacology ◽

10.1016/0028-3908(87)90040-2 ◽

1987 ◽

Vol 26 (1) ◽

pp. 25-31 ◽

Author(s):

H.J. Little ◽

D.J. Nutt ◽

S.C. Taylor

Keyword(s):

Benzodiazepine Receptor ◽

Fg 7142 ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

Chemical Kindling ◽

In Vivo Effects

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Purification and Characterization of Naturally Occurring Benzodiazepine Receptor Ligands in Rat and Human Brain

Journal of Neurochemistry ◽

10.1111/j.1471-4159.1992.tb10952.x ◽

1992 ◽

Vol 58 (6) ◽

pp. 2102-2115 ◽

Author(s):

Jeffrey D. Rothstein ◽

William Garland ◽

Gulia Puia ◽

Alessandro Guidotti ◽

Richard J. Weber ◽

...

Keyword(s):

Human Brain ◽

Benzodiazepine Receptor ◽

Receptor Ligands ◽

Purification And Characterization ◽

Benzodiazepine Receptor Ligands ◽

Naturally Occurring

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ChemInform Abstract: β-Carbolines as Agonistic or Antagonistic Benzodiazepine Receptor Ligands. Part 1. Synthesis of Some 5-, 6-, and 7-Amino Derivatives of 3-Methoxycarbonyl-β-carboline (β-CCM) and of 3-Ethoxycarbonyl-β-carboline (β-CCE).

10.1002/chin.198928195 ◽

1989 ◽

Vol 20 (28) ◽

Author(s):

G. SETTIMJ ◽

M. R. DEL GIUDICE ◽

R. FERRETTI ◽

F. GATTA

Keyword(s):

Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

Amino Derivatives ◽

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Reactivity of 7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines: Synthesis of pyrazolo[1,5-a]pyrido[3,4-e]pyrimidine derivatives as potential benzodiazepine receptor ligands.1

Journal of Heterocyclic Chemistry ◽

10.1002/jhet.5570310516 ◽

1994 ◽

Vol 31 (5) ◽

pp. 1193-1198 ◽

Author(s):

Fabrizio Bruni ◽

Silvia Selleri ◽

Annarella Costanzo ◽

Gabriella Guerrini ◽

Maria Lucia Casilli

Keyword(s):

Benzodiazepine Receptor ◽

Receptor Ligands ◽

Pyrimidine Derivatives ◽

Benzodiazepine Receptor Ligands

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