Thienothiopyran-2-sulfonamides: a novel class of water-soluble carbonic anhydrase inhibitors

Gerald S. Ponticello; Mark B. Freedman; Charles N. Habecker; Paulette A. Lyle; Harvey Schwam; Sandor L. Varga; Marcia E. Christy; William C. Randall; John J. Baldwin

doi:10.1021/jm00387a002

Thienothiopyran-2-sulfonamides: a novel class of water-soluble carbonic anhydrase inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm00387a002 ◽

1987 ◽

Vol 30 (4) ◽

pp. 591-597 ◽

Cited By ~ 69

Author(s):

Gerald S. Ponticello ◽

Mark B. Freedman ◽

Charles N. Habecker ◽

Paulette A. Lyle ◽

Harvey Schwam ◽

...

Keyword(s):

Carbonic Anhydrase ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

Soluble Carbonic Anhydrase

ChemInform Abstract: Thienothiopyran-2-sulfonamides: A Novel Class of Water-Soluble Carbonic Anhydrase Inhibitors.

ChemInform ◽

10.1002/chin.198737222 ◽

1987 ◽

Vol 18 (37) ◽

Author(s):

G. S. PONTICELLO ◽

M. B. FREEDMAN ◽

C. N. HABECKER ◽

P. A. LYLE ◽

H. SCHWAM ◽

...

Keyword(s):

Carbonic Anhydrase ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

Soluble Carbonic Anhydrase

Carbonic anhydrase inhibitors – part 70. Synthesis and ocular pharmacology of a new class of water-soluble, topically effective intraocular pressure lowering agents derived from nicotinic acid and aromatic/heterocyclic sulfonamides

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(99)00212-3 ◽

1999 ◽

Vol 34 (10) ◽

pp. 799-808 ◽

Cited By ~ 9

Author(s):

C Supuran

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Nicotinic Acid ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

New Class ◽

Pressure Lowering ◽

Aromatic Heterocyclic ◽

Ocular Pharmacology

Carbonic anhydrase inhibitors – Part 78. Synthesis of water-soluble sulfonamides incorporating β-alanyl moieties, possessing long lasting-intraocular pressure lowering properties via the topical route

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(00)00130-6 ◽

2000 ◽

Vol 35 (3) ◽

pp. 309-321 ◽

Cited By ~ 9

Author(s):

C Supuran

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering

Carbonic Anhydrase Inhibitors. Water-Soluble, Topically Effective Intraocular Pressure Lowering Agents Derived from Isonicotinic Acid and Aromatic/Heterocyclic Sulfonamides: Is the Tail More Important than the Ring?

Journal of Enzyme Inhibition ◽

10.3109/14756369909030336 ◽

1999 ◽

Vol 14 (6) ◽

pp. 457-474 ◽

Cited By ~ 19

Author(s):

Luca Menabuoni ◽

Andrea Scozzafava ◽

Francesco Mincione ◽

Fabrizio Briganti ◽

Giovanna Mincione ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Isonicotinic Acid ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering ◽

Aromatic Heterocyclic

QSAR study on carbonic anhydrase inhibitors: water-soluble sulfonamides incorporating β-alanyl moieties, possessing long lasting-intra ocular pressure lowering properties—a molecular connectivity approach

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2005.04.006 ◽

2005 ◽

Vol 40 (10) ◽

pp. 1002-1012 ◽

Cited By ~ 11

Author(s):

Vijay K. Agrawal ◽

Meghna Banerji ◽

Madhu Gupta ◽

Jyoti Singh ◽

Padmakar V. Khadikar ◽

...

Keyword(s):

Carbonic Anhydrase ◽

Water Soluble ◽

Molecular Connectivity ◽

Qsar Study ◽

Carbonic Anhydrase Inhibitors ◽

Intra Ocular Pressure ◽

Pressure Lowering ◽

Ocular Pressure

Carbonic Anhydrase Inhibitors: Synthesis of Water Soluble Sulfonamides Incorporating a 4-sulfamoylphenylmethylthiourea Scaffold, with Potent Intraocular Pressure Lowering Properties

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.1080/1475636021000010950 ◽

2002 ◽

Vol 17 (5) ◽

pp. 333-343 ◽

Cited By ~ 28

Author(s):

Angela Casini ◽

Andrea Scozzafava ◽

Francesco Mincione ◽

Luca Menabuoni ◽

Claudiu T. Supuran

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering

Carbonic Anhydrase Inhibitors: Water-Soluble 4-Sulfamoylphenylthioureas as Topical Intraocular Pressure-Lowering Agents with Long-Lasting Effects

Journal of Medicinal Chemistry ◽

10.1021/jm001051+ ◽

2000 ◽

Vol 43 (25) ◽

pp. 4884-4892 ◽

Cited By ~ 110

Author(s):

Angela Casini ◽

Andrea Scozzafava ◽

Francesco Mincione ◽

Luca Menabuoni ◽

Marc A. Ilies ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering

Carbonic Anhydrase Inhibitors. A General Approach for the Preparation of Water-Soluble Sulfonamides Incorporating Polyamino−Polycarboxylate Tails and of Their Metal Complexes Possessing Long-Lasting, Topical Intraocular Pressure-Lowering Properties

Journal of Medicinal Chemistry ◽

10.1021/jm0108202 ◽

2002 ◽

Vol 45 (7) ◽

pp. 1466-1476 ◽

Cited By ~ 106

Author(s):

Andrea Scozzafava ◽

Luca Menabuoni ◽

Francesco Mincione ◽

Claudiu T. Supuran

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Metal Complexes ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering

Carbonic Anhydrase Inhibitors. Synthesis of Water-Soluble, Topically Effective, Intraocular Pressure-Lowering Aromatic/Heterocyclic Sulfonamides Containing Cationic or Anionic Moieties: Is the Tail More Important than the Ring?1

Journal of Medicinal Chemistry ◽

10.1021/jm9900523 ◽

1999 ◽

Vol 42 (14) ◽

pp. 2641-2650 ◽

Cited By ~ 192

Author(s):

Andrea Scozzafava ◽

Luca Menabuoni ◽

Francesco Mincione ◽

Fabrizio Briganti ◽

Giovanna Mincione ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering ◽

Aromatic Heterocyclic

Carbonic Anhydrase Inhibitors: Synthesis of Water-Soluble, Aminoacyl/Dipeptidyl Sulfonamides Possessing Long-Lasting Intraocular Pressure-Lowering Properties via the Topical Route1

Journal of Medicinal Chemistry ◽

10.1021/jm9901879 ◽

1999 ◽

Vol 42 (18) ◽

pp. 3690-3700 ◽

Cited By ~ 106

Author(s):

Andrea Scozzafava ◽

Fabrizio Briganti ◽

Giovanna Mincione ◽

Luca Menabuoni ◽

Francesco Mincione ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering