Carbonic anhydrase inhibitors – part 70. Synthesis and ocular pharmacology of a new class of water-soluble, topically effective intraocular pressure lowering agents derived from nicotinic acid and aromatic/heterocyclic sulfonamides

New Class ◽

Pressure Lowering ◽

Aromatic Heterocyclic ◽

Ocular Pharmacology

ChemInform Abstract: Carbonic Anhydrase Inhibitors. Part 70. Synthesis and Ocular Pharmacology of a New Class of Water-Soluble, Topically Effective Intraocular Pressure Lowering Agents Derived from Nicotinic Acid and Aromatic/Heterocyclic Sulfonamides

ChemInform ◽

10.1002/chin.200006134 ◽

2010 ◽

Vol 31 (6) ◽

pp. no-no

Author(s):

Claudiu T. Supuran ◽

Andrea Scozzafava ◽

Luca Menabuoni ◽

Francesco Mincione ◽

Fabrizio Briganti ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Nicotinic Acid ◽

Water Soluble ◽

New Class ◽

Pressure Lowering ◽

Aromatic Heterocyclic ◽

Ocular Pharmacology

Carbonic Anhydrase Inhibitors. Water-Soluble, Topically Effective Intraocular Pressure Lowering Agents Derived from Isonicotinic Acid and Aromatic/Heterocyclic Sulfonamides: Is the Tail More Important than the Ring?

Journal of Enzyme Inhibition ◽

10.3109/14756369909030336 ◽

1999 ◽

Vol 14 (6) ◽

pp. 457-474 ◽

Cited By ~ 19

Author(s):

Luca Menabuoni ◽

Andrea Scozzafava ◽

Francesco Mincione ◽

Fabrizio Briganti ◽

Giovanna Mincione ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Isonicotinic Acid ◽

Water Soluble ◽

Pressure Lowering ◽

Aromatic Heterocyclic

Carbonic Anhydrase Inhibitors. Synthesis of Water-Soluble, Topically Effective, Intraocular Pressure-Lowering Aromatic/Heterocyclic Sulfonamides Containing Cationic or Anionic Moieties: Is the Tail More Important than the Ring?1

10.1021/jm9900523 ◽

1999 ◽

Vol 42 (14) ◽

pp. 2641-2650 ◽

Cited By ~ 192

Author(s):

Andrea Scozzafava ◽

Luca Menabuoni ◽

Francesco Mincione ◽

Fabrizio Briganti ◽

Giovanna Mincione ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Water Soluble ◽

Pressure Lowering ◽

Aromatic Heterocyclic

Carbonic anhydrase inhibitors – Part 78. Synthesis of water-soluble sulfonamides incorporating β-alanyl moieties, possessing long lasting-intraocular pressure lowering properties via the topical route

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(00)00130-6 ◽

2000 ◽

Vol 35 (3) ◽

pp. 309-321 ◽

Cited By ~ 9

Author(s):

C Supuran

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Water Soluble ◽

2-Benzylpiperazine: A new scaffold for potent human carbonic anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.04.002 ◽

2018 ◽

Vol 151 ◽

pp. 363-375 ◽

Cited By ~ 16

Author(s):

Niccolò Chiaramonte ◽

Silvia Bua ◽

Marta Ferraroni ◽

Alessio Nocentini ◽

Alessandro Bonardi ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Enzyme Inhibition ◽

New Class ◽

Pressure Lowering ◽

Human Carbonic Anhydrase

Carbonic Anhydrase Inhibitors: Synthesis of Water Soluble Sulfonamides Incorporating a 4-sulfamoylphenylmethylthiourea Scaffold, with Potent Intraocular Pressure Lowering Properties

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.1080/1475636021000010950 ◽

2002 ◽

Vol 17 (5) ◽

pp. 333-343 ◽

Cited By ~ 28

Author(s):

Angela Casini ◽

Andrea Scozzafava ◽

Francesco Mincione ◽

Luca Menabuoni ◽

Claudiu T. Supuran

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors: Water-Soluble 4-Sulfamoylphenylthioureas as Topical Intraocular Pressure-Lowering Agents with Long-Lasting Effects

10.1021/jm001051+ ◽

2000 ◽

Vol 43 (25) ◽

pp. 4884-4892 ◽

Cited By ~ 110

Author(s):

Angela Casini ◽

Andrea Scozzafava ◽

Francesco Mincione ◽

Luca Menabuoni ◽

Marc A. Ilies ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors. A General Approach for the Preparation of Water-Soluble Sulfonamides Incorporating Polyamino−Polycarboxylate Tails and of Their Metal Complexes Possessing Long-Lasting, Topical Intraocular Pressure-Lowering Properties

10.1021/jm0108202 ◽

2002 ◽

Vol 45 (7) ◽

pp. 1466-1476 ◽

Cited By ~ 106

Author(s):

Andrea Scozzafava ◽

Luca Menabuoni ◽

Francesco Mincione ◽

Claudiu T. Supuran

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Metal Complexes ◽

Water Soluble ◽

ChemInform Abstract: Carbonic Anhydrase Inhibitors. Part 52. Metal Complexes of Heterocyclic Sulfonamides: A New Class of Strong Topical Intraocular Pressure-Lowering Agents in Rabbits.

ChemInform ◽

10.1002/chin.199837153 ◽

2010 ◽

Vol 29 (37) ◽

pp. no-no

Author(s):

C. T. SUPURAN ◽

F. MINCIONE ◽

A. SCOZZAFAVA ◽

F. BRIGANTI ◽

G. MINCIONE ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Metal Complexes ◽

New Class ◽

Carbonic Anhydrase Inhibitors: Perfluoroalkyl/Aryl-Substituted Derivatives of Aromatic/Heterocyclic Sulfonamides as Topical Intraocular Pressure-Lowering Agents with Prolonged Duration of Action

10.1021/jm000296j ◽

2000 ◽

Vol 43 (23) ◽

pp. 4542-4551 ◽

Cited By ~ 90

Author(s):

Andrea Scozzafava ◽

Luca Menabuoni ◽

Francesco Mincione ◽

Fabrizio Briganti ◽

Giovanna Mincione ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Duration Of Action ◽

Prolonged Duration ◽

Pressure Lowering ◽

Derivatives Of ◽

Aromatic Heterocyclic ◽

Aryl Substituted Derivatives