Carbonic Anhydrase Inhibitors. Synthesis of Water-Soluble, Topically Effective, Intraocular Pressure-Lowering Aromatic/Heterocyclic Sulfonamides Containing Cationic or Anionic Moieties:  Is the Tail More Important than the Ring?1

Andrea Scozzafava; Luca Menabuoni; Francesco Mincione; Fabrizio Briganti; Giovanna Mincione; Claudiu T. Supuran

doi:10.1021/jm9900523

Carbonic Anhydrase Inhibitors. Synthesis of Water-Soluble, Topically Effective, Intraocular Pressure-Lowering Aromatic/Heterocyclic Sulfonamides Containing Cationic or Anionic Moieties: Is the Tail More Important than the Ring?1

Journal of Medicinal Chemistry ◽

10.1021/jm9900523 ◽

1999 ◽

Vol 42 (14) ◽

pp. 2641-2650 ◽

Cited By ~ 192

Author(s):

Andrea Scozzafava ◽

Luca Menabuoni ◽

Francesco Mincione ◽

Fabrizio Briganti ◽

Giovanna Mincione ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering ◽

Aromatic Heterocyclic

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Carbonic anhydrase inhibitors – part 70. Synthesis and ocular pharmacology of a new class of water-soluble, topically effective intraocular pressure lowering agents derived from nicotinic acid and aromatic/heterocyclic sulfonamides

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(99)00212-3 ◽

1999 ◽

Vol 34 (10) ◽

pp. 799-808 ◽

Cited By ~ 9

Author(s):

C Supuran

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Nicotinic Acid ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

New Class ◽

Pressure Lowering ◽

Aromatic Heterocyclic ◽

Ocular Pharmacology

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Carbonic Anhydrase Inhibitors. Water-Soluble, Topically Effective Intraocular Pressure Lowering Agents Derived from Isonicotinic Acid and Aromatic/Heterocyclic Sulfonamides: Is the Tail More Important than the Ring?

Journal of Enzyme Inhibition ◽

10.3109/14756369909030336 ◽

1999 ◽

Vol 14 (6) ◽

pp. 457-474 ◽

Cited By ~ 19

Author(s):

Luca Menabuoni ◽

Andrea Scozzafava ◽

Francesco Mincione ◽

Fabrizio Briganti ◽

Giovanna Mincione ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Isonicotinic Acid ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering ◽

Aromatic Heterocyclic

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ChemInform Abstract: Carbonic Anhydrase Inhibitors. Part 70. Synthesis and Ocular Pharmacology of a New Class of Water-Soluble, Topically Effective Intraocular Pressure Lowering Agents Derived from Nicotinic Acid and Aromatic/Heterocyclic Sulfonamides

ChemInform ◽

10.1002/chin.200006134 ◽

2010 ◽

Vol 31 (6) ◽

pp. no-no

Author(s):

Claudiu T. Supuran ◽

Andrea Scozzafava ◽

Luca Menabuoni ◽

Francesco Mincione ◽

Fabrizio Briganti ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Nicotinic Acid ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

New Class ◽

Pressure Lowering ◽

Aromatic Heterocyclic ◽

Ocular Pharmacology

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Carbonic anhydrase inhibitors – Part 78. Synthesis of water-soluble sulfonamides incorporating β-alanyl moieties, possessing long lasting-intraocular pressure lowering properties via the topical route

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(00)00130-6 ◽

2000 ◽

Vol 35 (3) ◽

pp. 309-321 ◽

Cited By ~ 9

Author(s):

C Supuran

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering

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Carbonic Anhydrase Inhibitors: Synthesis of Water Soluble Sulfonamides Incorporating a 4-sulfamoylphenylmethylthiourea Scaffold, with Potent Intraocular Pressure Lowering Properties

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.1080/1475636021000010950 ◽

2002 ◽

Vol 17 (5) ◽

pp. 333-343 ◽

Cited By ~ 28

Author(s):

Angela Casini ◽

Andrea Scozzafava ◽

Francesco Mincione ◽

Luca Menabuoni ◽

Claudiu T. Supuran

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering

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Carbonic Anhydrase Inhibitors: Water-Soluble 4-Sulfamoylphenylthioureas as Topical Intraocular Pressure-Lowering Agents with Long-Lasting Effects

Journal of Medicinal Chemistry ◽

10.1021/jm001051+ ◽

2000 ◽

Vol 43 (25) ◽

pp. 4884-4892 ◽

Cited By ~ 110

Author(s):

Angela Casini ◽

Andrea Scozzafava ◽

Francesco Mincione ◽

Luca Menabuoni ◽

Marc A. Ilies ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering

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Carbonic Anhydrase Inhibitors. A General Approach for the Preparation of Water-Soluble Sulfonamides Incorporating Polyamino−Polycarboxylate Tails and of Their Metal Complexes Possessing Long-Lasting, Topical Intraocular Pressure-Lowering Properties

Journal of Medicinal Chemistry ◽

10.1021/jm0108202 ◽

2002 ◽

Vol 45 (7) ◽

pp. 1466-1476 ◽

Cited By ~ 106

Author(s):

Andrea Scozzafava ◽

Luca Menabuoni ◽

Francesco Mincione ◽

Claudiu T. Supuran

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Metal Complexes ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering

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Carbonic Anhydrase Inhibitors: Perfluoroalkyl/Aryl-Substituted Derivatives of Aromatic/Heterocyclic Sulfonamides as Topical Intraocular Pressure-Lowering Agents with Prolonged Duration of Action

Journal of Medicinal Chemistry ◽

10.1021/jm000296j ◽

2000 ◽

Vol 43 (23) ◽

pp. 4542-4551 ◽

Cited By ~ 90

Author(s):

Andrea Scozzafava ◽

Luca Menabuoni ◽

Francesco Mincione ◽

Fabrizio Briganti ◽

Giovanna Mincione ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Duration Of Action ◽

Carbonic Anhydrase Inhibitors ◽

Prolonged Duration ◽

Pressure Lowering ◽

Derivatives Of ◽

Aromatic Heterocyclic ◽

Aryl Substituted Derivatives

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Carbonic Anhydrase Inhibitors: Synthesis of Water-Soluble, Aminoacyl/Dipeptidyl Sulfonamides Possessing Long-Lasting Intraocular Pressure-Lowering Properties via the Topical Route1

Journal of Medicinal Chemistry ◽

10.1021/jm9901879 ◽

1999 ◽

Vol 42 (18) ◽

pp. 3690-3700 ◽

Cited By ~ 106

Author(s):

Andrea Scozzafava ◽

Fabrizio Briganti ◽

Giovanna Mincione ◽

Luca Menabuoni ◽

Francesco Mincione ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering

Download Full-text

ChemInform Abstract: Carbonic Anhydrase Inhibitors. Part 78. Synthesis of Water-Soluble Sulfonamides Incorporating β-Alanyl Moieties, Possessing Long Lasting-Intraocular Pressure Lowering Properties via the Topical Route.

ChemInform ◽

10.1002/chin.200031244 ◽

2010 ◽

Vol 31 (31) ◽

pp. no-no

Author(s):

Claudiu T. Supuran ◽

Fabrizio Briganti ◽

Luca Menabuoni ◽

Giovanna Mincione ◽

Francesco Mincione ◽

...

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

Pressure Lowering

Download Full-text