Structure−Activity Relationships of a Novel Class of Endothelin-A Receptor Antagonists and Discovery of Potent and Selective Receptor Antagonist, 2-(Benzo[1,3]dioxol-5-yl)-6-isopropyloxy-4-(4-methoxyphenyl)-2H-chromene-3- carboxylic Acid (S-1255). 1. Study on Structure−Activity Relationships and Basic Structure Crucial for ETAAntagonism

2002 ◽  
Vol 45 (10) ◽  
pp. 2041-2055 ◽  
Author(s):  
Natsuki Ishizuka ◽  
Ken-ichi Matsumura ◽  
Katsunori Sakai ◽  
Masafumi Fujimoto ◽  
Shin-ichi Mihara ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Receptor Antagonist ◽  
Basic Structure ◽  
Receptor Antagonists ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Endothelin A Receptor ◽  
Endothelin A

Selective endothelin A receptor antagonists. 2. Discovery and structure-activity relationships of 5-ketopentanoic acid derivatives

1997 ◽  
Vol 32 (6) ◽  
pp. 515-522 ◽  
Author(s):  
P.C. Astles ◽  
T.J. Brown ◽  
N.V. Harris ◽  
M.F. Harper ◽  
C McCarthy ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Endothelin A Receptor ◽  
Endothelin A

Synthesis and structure-activity relationships of 9-substituted acridines as endothelin-A receptor antagonists

1996 ◽  
Vol 6 (24) ◽  
pp. 2999-3002 ◽  
Author(s):  
X.-M. Cheng ◽  
C. Lee ◽  
S. Klutchko ◽  
T. Winters ◽  
E.E. Reynolds ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Endothelin A Receptor ◽  
Endothelin A

Selective Endothelin A Receptor Antagonists. 4. Discovery and Structure−Activity Relationships of Stilbene Acid and Alcohol Derivatives1-3

1998 ◽  
Vol 41 (15) ◽  
pp. 2745-2753 ◽  
Author(s):  
Peter C. Astles ◽  
Thomas J. Brown ◽  
Frank Halley ◽  
Caroline M. Handscombe ◽  
Neil V. Harris ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Endothelin A Receptor ◽  
Endothelin A

ChemInform Abstract: Synthesis and Structure-Activity Relationships of 9-Substituted Acridines as Endothelin-A Receptor Antagonists.

ChemInform ◽  
2010 ◽  
Vol 28 (23) ◽  
pp. no-no
Author(s):  
X.-M. CHENG ◽  
C. LEE ◽  
S. KLUTCHKO ◽  
T. WINTERS ◽  
E. E. REYNOLDS ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Endothelin A Receptor ◽  
Endothelin A

Selective Endothelin A Receptor Antagonists. 3. Discovery and Structure−Activity Relationships of a Series of 4-Phenoxybutanoic Acid Derivatives

1998 ◽  
Vol 41 (15) ◽  
pp. 2732-2744 ◽  
Author(s):  
Peter C. Astles ◽  
Clive Brealey ◽  
Thomas J. Brown ◽  
Vincenzo Facchini ◽  
Caroline Handscombe ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Endothelin A Receptor ◽  
Endothelin A

ChemInform Abstract: Selective Endothelin A Receptor Antagonists. Part 2. Discovery and Structure-Activity Relationships of 5-Ketopentanoic Acid Derivatives.

ChemInform ◽  
2010 ◽  
Vol 28 (43) ◽  
pp. no-no
Author(s):  
P. C. ASTLES ◽  
T. J. BROWN ◽  
N. V. HARRIS ◽  
M. F. HARPER ◽  
C. MCCARTHY ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Endothelin A Receptor ◽  
Endothelin A

Structure-Activity Relationships of Cyclic Pentapeptide Endothelin A Receptor Antagonists

1995 ◽  
Vol 38 (21) ◽  
pp. 4309-4324 ◽  
Author(s):  
Takehiro Fukami ◽  
Toshio Nagase ◽  
Kagari Fujita ◽  
Takashi Hayama ◽  
Kenji Niiyama ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Endothelin A Receptor ◽  
Endothelin A
Sign in / Sign up

Export Citation Format

Share Document