Design, Synthesis, and Structure−Activity Relationships of Thieno[2,3-b]pyridin-4-one Derivatives as a Novel Class of Potent, Orally Active, Non-Peptide Luteinizing Hormone-Releasing Hormone Receptor Antagonists

Takashi Imada; Nobuo Cho; Toshihiro Imaeda; Yoji Hayase; Satoshi Sasaki; Shizuo Kasai; Masataka Harada; Hirokazu Matsumoto; Satoshi Endo; Nobuhiro Suzuki; Shuichi Furuya

doi:10.1021/jm0512894

Design, Synthesis, and Structure−Activity Relationships of Thieno[2,3-b]pyridin-4-one Derivatives as a Novel Class of Potent, Orally Active, Non-Peptide Luteinizing Hormone-Releasing Hormone Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm0512894 ◽

2006 ◽

Vol 49 (13) ◽

pp. 3809-3825 ◽

Cited By ~ 13

Author(s):

Takashi Imada ◽

Nobuo Cho ◽

Toshihiro Imaeda ◽

Yoji Hayase ◽

Satoshi Sasaki ◽

...

Keyword(s):

Luteinizing Hormone ◽

Hormone Receptor ◽

Receptor Antagonists ◽

Design Synthesis ◽

Luteinizing Hormone Releasing Hormone ◽

Releasing Hormone ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Corrigendum to “Design, synthesis, and structure–activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists” [Bioorg. Med. Chem. 22 (2014) 6071–6088]

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.04.042 ◽

2015 ◽

Vol 23 (13) ◽

pp. 3870

Author(s):

Yu Yoshida ◽

Taro Terauchi ◽

Yoshimitsu Naoe ◽

Yuji Kazuta ◽

Fumihiro Ozaki ◽

...

Keyword(s):

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Design, synthesis, and structure–activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.08.034 ◽

2014 ◽

Vol 22 (21) ◽

pp. 6071-6088 ◽

Cited By ~ 12

Author(s):

Yu Yoshida ◽

Taro Terauchi ◽

Yoshimitsu Naoe ◽

Yuji Kazuta ◽

Fumihiro Ozaki ◽

...

Keyword(s):

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Structure-activity relationships in luteinizing hormone-releasing hormone

Journal of Medicinal Chemistry ◽

10.1021/jm00226a008 ◽

1976 ◽

Vol 19 (4) ◽

pp. 492-495 ◽

Cited By ~ 19

Author(s):

Kari U. Prasad ◽

Roger W. Roeske ◽

Frederick L. Weitl ◽

Jesus A. Vilchez-Martinez ◽

Andrew V. Schally

Keyword(s):

Luteinizing Hormone ◽

Luteinizing Hormone Releasing Hormone ◽

Releasing Hormone ◽

Structure Activity Relationships ◽

Structure Activity

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ChemInform Abstract: FURTHER STUDIES ON THE STRUCTURE-ACTIVITY RELATIONSHIPS IN THE C-TERMINAL PART OF LUTEINIZING HORMONE-RELEASING HORMONE

Chemischer Informationsdienst ◽

10.1002/chin.197404387 ◽

1974 ◽

Vol 5 (4) ◽

pp. no-no

Author(s):

M. FUJINO ◽

S. SHINAGAWA ◽

M. OBAYASHI ◽

S. KOBAYASHI ◽

T. FUKUDA ◽

...

Keyword(s):

Luteinizing Hormone ◽

Terminal Part ◽

Luteinizing Hormone Releasing Hormone ◽

Releasing Hormone ◽

Structure Activity Relationships ◽

Structure Activity

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Structure–activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.05.038 ◽

2005 ◽

Vol 15 (16) ◽

pp. 3685-3690 ◽

Cited By ~ 9

Author(s):

Zhiqiang Guo ◽

Dongpei Wu ◽

Yun-Fei Zhu ◽

Fabio C. Tucci ◽

Collin F. Regan ◽

...

Keyword(s):

Hormone Receptor ◽

Gonadotropin Releasing Hormone ◽

Receptor Antagonists ◽

Releasing Hormone ◽

Structure Activity Relationships ◽

Structure Activity ◽

Gonadotropin Releasing Hormone Receptor

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Structure-activity relationships in the C-terminal part of luteinizing hormone releasing hormone (LH-RH)

Biochemical and Biophysical Research Communications ◽

10.1016/0006-291x(72)90490-1 ◽

1972 ◽

Vol 49 (3) ◽

pp. 863-869 ◽

Cited By ~ 109

Author(s):

M. Fujino ◽

S. Kobayashi ◽

M. Obayashi ◽

S. Shinagawa ◽

T. Fukuda ◽

...

Keyword(s):

Luteinizing Hormone ◽

Terminal Part ◽

Luteinizing Hormone Releasing Hormone ◽

Releasing Hormone ◽

Structure Activity Relationships ◽

Structure Activity ◽

Lh Rh

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Synthesis and Structure−Activity Relationships of 1-Arylmethyl-5-aryl-6-methyluracils as Potent Gonadotropin-Releasing Hormone Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm030472z ◽

2004 ◽

Vol 47 (5) ◽

pp. 1259-1271 ◽

Cited By ~ 36

Author(s):

Zhiqiang Guo ◽

Yun-Fei Zhu ◽

Timothy D. Gross ◽

Fabio C. Tucci ◽

Yinghong Gao ◽

...

Keyword(s):

Hormone Receptor ◽

Gonadotropin Releasing Hormone ◽

Receptor Antagonists ◽

Releasing Hormone ◽

Structure Activity Relationships ◽

Structure Activity ◽

Gonadotropin Releasing Hormone Receptor

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Design, Synthesis, and Structure–Activity Relationships of Novel Pyrazolo[5,1-b]thiazole Derivatives as Potent and Orally Active Corticotropin-Releasing Factor 1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm300864p ◽

2012 ◽

Vol 55 (19) ◽

pp. 8450-8463 ◽

Cited By ~ 9

Author(s):

Yoshinori Takahashi ◽

Minako Hashizume ◽

Kogyoku Shin ◽

Taro Terauchi ◽

Kunitoshi Takeda ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Thiazole Derivatives ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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Inhibition of testicular luteinizing hormone receptor level by treatment with a potent luteinizing hormone-releasing hormone agonist or human chorionic gonadotropin

Biochemical and Biophysical Research Communications ◽

10.1016/0006-291x(77)91579-0 ◽

1977 ◽

Vol 76 (3) ◽

pp. 855-862 ◽

Cited By ~ 126

Author(s):

Claude Auclair ◽

Paul A. Kelly ◽

Fernand Labrie ◽

David H. Coy ◽

Andrew V. Schally

Keyword(s):

Luteinizing Hormone ◽

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Hormone Receptor ◽

Luteinizing Hormone Receptor ◽

Luteinizing Hormone Releasing Hormone ◽

Receptor Level ◽

Releasing Hormone ◽

Hormone Receptor Level

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Luteinizing hormone–releasing hormone receptor antagonist may reduce postmenopausal flushing

Menopause The Journal of The North American Menopause Society ◽

10.1097/gme.0b013e31822542ca ◽

2012 ◽

Vol 19 (2) ◽

pp. 178-185 ◽

Cited By ~ 3

Author(s):

Petri van Gastel ◽

Moniek van der Zanden ◽

Darryl Telting ◽

Margreet Filius ◽

Laszlo Bancsi ◽

...

Keyword(s):

Luteinizing Hormone ◽

Receptor Antagonist ◽

Hormone Receptor ◽

Luteinizing Hormone Releasing Hormone ◽

Releasing Hormone

Download Full-text