scholarly journals Design, Synthesis, and In Vitro Evaluation of Carbamate Derivatives of 2-Benzoxazolyl- and 2-Benzothiazolyl-(3-hydroxyphenyl)-methanones as Novel Fatty Acid Amide Hydrolase Inhibitors

2007 ◽  
Vol 50 (17) ◽  
pp. 4236-4242 ◽  
Author(s):  
Mikko J. Myllymäki ◽  
Susanna M. Saario ◽  
Antti O. Kataja ◽  
Joel A. Castillo-Melendez ◽  
Tapio Nevalainen ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Design Synthesis ◽  
In Vitro Evaluation ◽  
Amide Hydrolase ◽  
Derivatives Of ◽  
Fatty Acid Amide

scholarly journals Design, Synthesis, and In Vitro Evaluation of Carbamate Derivatives of 2-Benzoxazolyl- and 2-Benzothiazolyl-(3-hydroxyphenyl)-methanones as Novel Fatty Acid Amide Hydrolase Inhibitors.

2007 ◽  
Vol 50 (23) ◽  
pp. 5868-5868
Author(s):  
Mikko J. Myllymäki ◽  
Susanna M. Saario ◽  
Antti O. Kataja ◽  
Joel A. Castillo-Melendez ◽  
Tapio Nevalainen ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Design Synthesis ◽  
In Vitro Evaluation ◽  
Amide Hydrolase ◽  
Derivatives Of ◽  
Fatty Acid Amide

Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors

2014 ◽  
Vol 22 (4) ◽  
pp. 1468-1478 ◽  
Author(s):  
Mitsunori Kono ◽  
Takahiro Matsumoto ◽  
Toshihiro Imaeda ◽  
Toru Kawamura ◽  
Shinji Fujimoto ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Amide Hydrolase ◽  
Synthesis And Biological Evaluation ◽  
Fatty Acid Amide

ω-Imidazolyl- and ω-Tetrazolylalkylcarbamates as Inhibitors of Fatty Acid Amide Hydrolase: Biological Activity and in vitro Metabolic Stability

ChemMedChem ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. 429-443 ◽  
Author(s):  
Tobias Terwege ◽  
Walburga Hanekamp ◽  
David Garzinsky ◽  
Simone König ◽  
Oliver Koch ◽  
...  
Keyword(s):  
Biological Activity ◽  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Metabolic Stability ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

scholarly journals Fatty acid amide hydrolase (FAAH) inhibitor PF-3845 reduces viability, migration and invasiveness of human colon adenocarcinoma Colo-205 cell line: an in vitro study

2017 ◽  
Vol 64 (3) ◽  
pp. 519-525 ◽  
Author(s):  
Andrzej Wasilewski ◽  
Urszula Krajewska ◽  
Katarzyna Owczarek ◽  
Urszula Lewandowska ◽  
Jakub Fichna
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Colon Adenocarcinoma ◽  
In Vitro Study ◽  
Human Colon ◽  
Amide Hydrolase ◽  
Human Colon Adenocarcinoma ◽  
Fatty Acid Amide

Discovery of heterocyclic carbohydrazide derivatives as novel selective fatty acid amide hydrolase inhibitors: design, synthesis and anti-neuroinflammatory evaluation

2020 ◽  
Vol 30 (10) ◽  
pp. 127118 ◽  
Author(s):  
Yanguo Shang ◽  
Qingjing Hao ◽  
Kaixuan Jiang ◽  
Mengting He ◽  
Jinxin Wang
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Design Synthesis ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

In vitro and in vivo pharmacological characterization of ASP8477: A novel highly selective fatty acid amide hydrolase inhibitor

2017 ◽  
Vol 815 ◽  
pp. 42-48 ◽  
Author(s):  
Tomonari Watabiki ◽  
Noriko Tsuji ◽  
Tetsuo Kiso ◽  
Tohru Ozawa ◽  
Fumie Narazaki ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Pharmacological Characterization ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

Inhibition of fatty acid amide hydrolase and cyclooxygenase by the N-(3-methylpyridin-2-yl)amide derivatives of flurbiprofen and naproxen

2013 ◽  
Vol 720 (1-3) ◽  
pp. 383-390 ◽  
Author(s):  
Mariateresa Cipriano ◽  
Emmelie Björklund ◽  
Alan A. Wilson ◽  
Cenzo Congiu ◽  
Valentina Onnis ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Amide Derivatives ◽  
Amide Hydrolase ◽  
Derivatives Of ◽  
Fatty Acid Amide

scholarly journals N-Cyclohexanecarbonylpentadecylamine: a selective inhibitor of the acid amidase hydrolysing N-acylethanolamines, as a tool to distinguish acid amidase from fatty acid amide hydrolase

2004 ◽  
Vol 379 (1) ◽  
pp. 99-106 ◽  
Author(s):  
Kazuhito TSUBOI ◽  
Christine HILLIGSMANN ◽  
Séverine VANDEVOORDE ◽  
Didier M. LAMBERT ◽  
Natsuo UEDA
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Physiological Role ◽  
Ph Optimum ◽  
Ph Values ◽  
Amide Hydrolase ◽  
Derivatives Of ◽  
Fatty Acid Amide

Anandamide (N-arachidonoylethanolamine) and other bioactive N-acylethanolamines are degraded to their corresponding fatty acids and ethanolamine. This hydrolysis is mostly attributed to catalysis by FAAH (fatty acid amide hydrolase), which exhibits an alkaline pH optimum. In addition, we have identified another amidase which catalyses the same reaction exclusively at acidic pH values [Ueda, Yamanaka and Yamamoto (2001) J. Biol. Chem. 276, 35552–35557]. In attempts to find selective inhibitors of this acid amidase, we screened various derivatives of palmitic acid, 1-hexadecanol, and 1-pentadecylamine with N-palmitoylethanolamine as substrate. Here we show that N-cyclohexanecarbonylpentadecylamine inhibits the acid amidase from rat lung with an IC50 of 4.5 µM, without inhibiting FAAH at concentrations up to 100 µM. The inhibition was reversible and non-competitive. This compound also inhibited the acid amidase in intact alveolar macrophages. With the aid of this inhibitor, it was revealed that rat basophilic leukaemia cells possess the acid amidase as well as FAAH. Thus the inhibitor may be a useful tool to distinguish the acid amidase from FAAH in various tissues and cells and to elucidate the physiological role of the enzyme.

scholarly journals Exploring the fatty acid amide hydrolase and cyclooxygenase inhibitory properties of novel amide derivatives of ibuprofen

2020 ◽  
Vol 35 (1) ◽  
pp. 815-823 ◽  
Author(s):  
Alessandro Deplano ◽  
Jessica Karlsson ◽  
Mona Svensson ◽  
Federica Moraca ◽  
Bruno Catalanotti ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Amide Derivatives ◽  
Amide Hydrolase ◽  
Derivatives Of ◽  
Fatty Acid Amide
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