Design, Synthesis, and Pharmacological Evaluation ofN-Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase-4 Inhibitors

2012 ◽  
Vol 55 (17) ◽  
pp. 7525-7545 ◽  
Author(s):  
Arthur E. Kümmerle ◽  
Martine Schmitt ◽  
Suzana V. S. Cardozo ◽  
Claire Lugnier ◽  
Pascal Villa ◽  
...  
Keyword(s):  
Design Synthesis ◽  
Conformationally Constrained ◽  
Phosphodiesterase 4 ◽  
Pharmacological Evaluation ◽  
Phosphodiesterase 4 Inhibitors ◽  
Orally Active

CDP840. A prototype of a novel class of orally active anti-Inflammatory phosphodiesterase 4 inhibitors

2002 ◽  
Vol 12 (11) ◽  
pp. 1451-1456 ◽  
Author(s):  
R.P. Alexander ◽  
G.J. Warrellow ◽  
M.A.W. Eaton ◽  
E.C. Boyd ◽  
J.C. Head ◽  
...  
Keyword(s):  
Phosphodiesterase 4 ◽  
Phosphodiesterase 4 Inhibitors ◽  
Anti Inflammatory ◽  
Orally Active

Novel Quinazolin-4(3H)-one/Schiff Base Hybrids as Antiproliferative and Phosphodiesterase 4 Inhibitors: Design, Synthesis, and Docking Studies

2014 ◽  
Vol 347 (9) ◽  
pp. 650-657 ◽  
Author(s):  
Hamdy M. Abdel-Rahman ◽  
Mohamed Abdel-Aziz ◽  
Joshua C. Canzoneri ◽  
Bernard D. Gary ◽  
Gary A. Piazza
Keyword(s):  
Schiff Base ◽  
Docking Studies ◽  
Design Synthesis ◽  
Phosphodiesterase 4 ◽  
Phosphodiesterase 4 Inhibitors

Design, Synthesis, and Pharmacological Evaluation of Piperidin-4-yl amino aryl sulfonamides: Novel, Potent, Selective, Orally Active, and Brain Penetrant 5-HT6 Receptor Antagonists

2012 ◽  
Vol 55 (21) ◽  
pp. 9255-9269 ◽  
Author(s):  
Ramakrishna Nirogi ◽  
Anil Shinde ◽  
Anand Daulatabad ◽  
Ramasastri Kambhampati ◽  
Parandhama Gudla ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Design Synthesis ◽  
Pharmacological Evaluation ◽  
Orally Active

Wirksamkeit des neuen Phosphodiesterase 4-Inhibitors Roflumilast bei Rauchern und Exrauchern mit COPD

Pneumologie ◽  
2012 ◽  
Vol 66 (S 01) ◽  
Author(s):  
A Kroker ◽  
J Eller ◽  
A Linnhof ◽  
H Rusch ◽  
H Worth ◽  
...  
Keyword(s):  
Phosphodiesterase 4 ◽  
Phosphodiesterase 4 Inhibitors
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