Discovery of the CCR1 Antagonist, BMS-817399, for the Treatment of Rheumatoid Arthritis

Journal of Medicinal Chemistry ◽

10.1021/jm5003167 ◽

2014 ◽

Vol 57 (18) ◽

pp. 7550-7564 ◽

Author(s):

Joseph B. Santella ◽

Daniel S. Gardner ◽

John V. Duncia ◽

Hong Wu ◽

Murali Dhar ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Ccr1 Antagonist

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Chemokine receptor CCR1 antagonist CCX354-C treatment for rheumatoid arthritis: CARAT-2, a randomised, placebo controlled clinical trial

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2011-201605 ◽

2012 ◽

Vol 72 (3) ◽

pp. 337-344 ◽

Author(s):

Paul P Tak ◽

Andra Balanescu ◽

Vira Tseluyko ◽

Silvia Bojin ◽

Edit Drescher ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Clinical Trial ◽

Chemokine Receptor ◽

Controlled Clinical Trial ◽

Ccr1 Antagonist

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OP0203 Orally-administered CCR1 antagonist CCX354-C in a phase 2 rheumatoid arthritis study:

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2012-eular.1886 ◽

2013 ◽

Vol 71 (Suppl 3) ◽

pp. 123.3-124

Author(s):

P.P. Tak ◽

A. Balanescu ◽

V. Tseluyko ◽

S. Bojin ◽

E. Drescher ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Phase 2 ◽

Ccr1 Antagonist

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THU0109 Lack of Efficacy of CCR1 Antagonist BMS-817399 in Patients with Moderate to Severe Rheumatoid Arthritis: Results of 12-Week Proof-Of-Concept Study

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2014-eular.3871 ◽

2014 ◽

Vol 73 (Suppl 2) ◽

pp. 215.1-215 ◽

Author(s):

A. Kivitz ◽

P. Maciag ◽

P. Gulati ◽

S. Du ◽

S.E. Connolly ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Proof Of Concept ◽

Severe Rheumatoid Arthritis ◽

Concept Study ◽

Ccr1 Antagonist

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MLN3897 plus methotrexate in patients with rheumatoid arthritis: Safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study

Arthritis & Rheumatism ◽

10.1002/art.24978 ◽

2009 ◽

Vol 60 (12) ◽

pp. 3572-3581 ◽

Author(s):

Clarissa E. Vergunst ◽

Danielle M. Gerlag ◽

Lisa von Moltke ◽

Michael Karol ◽

Tim Wyant ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Proof Of Concept ◽

Pharmacokinetics And Pharmacodynamics ◽

Double Blind ◽

Double Blind Placebo ◽

Concept Study ◽

Ccr1 Antagonist

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The Cure of Rheumatoid Arthritis and Related Conditions (Osteoarthritis, Bursitis, Frozen Shoulder, etc.) by Physical Medicine: A Result of Thirty Years' Study (Original Investigations)

Journal of the American Medical Association ◽

10.1001/jama.1951.03670320105040 ◽

1951 ◽

Vol 147 (15) ◽

pp. 1505

Keyword(s):

Rheumatoid Arthritis ◽

Frozen Shoulder ◽

Physical Medicine

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Association of vitamin D receptor genotypes with early onset rheumatoid arthritis

European Journal of Immunogenetics ◽

10.1046/j.1365-2370.2001.00233.x ◽

2001 ◽

Vol 28 (1) ◽

pp. 89-93 ◽

Author(s):

J. R. Garcia-Lozano ◽

M. F. Gonzalez-Escribano ◽

A. Valenzuela ◽

A. Garcia ◽

A. Nunez-Roldan

Keyword(s):

Rheumatoid Arthritis ◽

Vitamin D ◽

Vitamin D Receptor ◽

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Demyelinating events in rheumatoid arthritis after drug exposures

Yearbook of Neurology and Neurosurgery ◽

10.1016/j.yneu.2010.12.009 ◽

2011 ◽

Vol 2011 ◽

pp. 96

Author(s):

A. Minagar

Keyword(s):

Rheumatoid Arthritis

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W01.92 CD4+ T lymphocyte expansion and early atherosclerotic disease in rheumatoid arthritis

Atherosclerosis ◽

10.1016/s0021-9150(04)90092-5 ◽

2004 ◽

Vol 5 (1) ◽

pp. 21

Author(s):

G VAUDO

Keyword(s):

Rheumatoid Arthritis ◽

T Lymphocyte ◽

Atherosclerotic Disease

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W01.69 Analysis of specific markers of protein oxidation in rheumatoid arthritis plasma and synovial fluid LDL

Atherosclerosis ◽

10.1016/s0021-9150(04)90069-x ◽

2004 ◽

Vol 5 (1) ◽

pp. 16

Author(s):

J PIETZSCH

Keyword(s):

Rheumatoid Arthritis ◽

Synovial Fluid ◽

Protein Oxidation

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An alternative splinting and rehabilitation protocol for metacarpophalangeal joint arthroplasty in patients with rheumatoid arthritis

Journal of Hand Therapy ◽

10.1016/s0894-1130(02)50008-9 ◽

2002 ◽

Vol 15 (1) ◽

pp. 41-47

Author(s):

N. Burr ◽

A. L. Pratt ◽

P. J. Smith

Keyword(s):

Rheumatoid Arthritis ◽

Metacarpophalangeal Joint ◽

Joint Arthroplasty ◽

Rehabilitation Protocol

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