Discovery of Small-Molecule Inhibitors Selectively Targeting the DNA-Binding Domain of the Human Androgen Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm500802j ◽

2014 ◽

Vol 57 (15) ◽

pp. 6458-6467 ◽

Author(s):

Huifang Li ◽

Fuqiang Ban ◽

Kush Dalal ◽

Eric Leblanc ◽

Kate Frewin ◽

...

Keyword(s):

Androgen Receptor ◽

Dna Binding ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Binding Domain ◽

Dna Binding Domain ◽

Human Androgen Receptor

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Faculty Opinions recommendation of Discovery of small-molecule inhibitors selectively targeting the DNA-binding domain of the human androgen receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718506308.793501749 ◽

2014 ◽

Author(s):

Martin Stahl

Keyword(s):

Androgen Receptor ◽

Dna Binding ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Binding Domain ◽

Dna Binding Domain ◽

Human Androgen Receptor

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Correction to Discovery of Small-Molecule Inhibitors Selectively Targeting the DNA-Binding Domain of the Human Androgen Receptor

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b00005 ◽

2017 ◽

Vol 60 (3) ◽

pp. 1225-1225 ◽

Author(s):

Huifang Li ◽

Fuqiang Ban ◽

Kush Dalal ◽

Eric Leblanc ◽

Kate Frewin ◽

...

Keyword(s):

Androgen Receptor ◽

Dna Binding ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Binding Domain ◽

Dna Binding Domain ◽

Human Androgen Receptor

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Amino acid substitutions in the DNA-binding domain of the human androgen receptor are a frequent cause of receptor-binding positive androgen resistance.

Molecular Endocrinology ◽

10.1210/mend.6.3.1316540 ◽

1992 ◽

Vol 6 (3) ◽

pp. 409-415

Author(s):

S Zoppi ◽

M Marcelli ◽

J P Deslypere ◽

J E Griffin ◽

J D Wilson ◽

...

Keyword(s):

Androgen Receptor ◽

Dna Binding ◽

Receptor Binding ◽

Binding Domain ◽

Amino Acid Substitutions ◽

Dna Binding Domain ◽

Androgen Resistance ◽

Human Androgen Receptor

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Erratum: Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo

Oncogene ◽

10.1038/onc.2015.419 ◽

2016 ◽

Vol 35 (6) ◽

pp. 802-802 ◽

Author(s):

W Huang ◽

Z Dong ◽

Y Chen ◽

F Wang ◽

C J Wang ◽

...

Keyword(s):

Gene Expression ◽

Dna Binding ◽

Tumor Growth ◽

Small Molecule ◽

Target Gene ◽

Small Molecule Inhibitors ◽

Binding Domain ◽

Dna Binding Domain ◽

Target Gene Expression

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Complete androgen insensitivity due to mutations in the probable -helical segments of the DNA-binding domain in the human androgen receptor

Human Molecular Genetics ◽

10.1093/hmg/3.1.21 ◽

1994 ◽

Vol 3 (1) ◽

pp. 21-27 ◽

Author(s):

L. K. Beitel ◽

L. Prior ◽

D. M. Vaslliou ◽

B. Gottlleb ◽

M. Kaufman ◽

...

Keyword(s):

Androgen Receptor ◽

Dna Binding ◽

Binding Domain ◽

Dna Binding Domain ◽

Androgen Insensitivity ◽

Human Androgen Receptor

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Abstract 1727: DNA-binding domain as an alternative target site on androgen receptor for prostate cancer therapy: Pre-clinicalin vivostudy of a novel small molecule for drug development

10.1158/1538-7445.am2015-1727 ◽

2015 ◽

Author(s):

Mohamed DH Hassona ◽

Leslie G. Chan ◽

Gray R. Meckling ◽

Huifang Li ◽

Eric LeBlanc ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Cancer Therapy ◽

Dna Binding ◽

Drug Development ◽

Small Molecule ◽

Binding Domain ◽

Target Site ◽

Dna Binding Domain ◽

Prostate Cancer Therapy

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Amino acid substitutions in the DNA-binding domain of the human androgen receptor are a frequent cause of receptor-binding positive androgen resistance

Molecular Endocrinology ◽

10.1210/me.6.3.409 ◽

1992 ◽

Vol 6 (3) ◽

pp. 409-415 ◽

Author(s):

S. Zoppi

Keyword(s):

Androgen Receptor ◽

Dna Binding ◽

Receptor Binding ◽

Binding Domain ◽

Amino Acid Substitutions ◽

Dna Binding Domain ◽

Androgen Resistance ◽

Human Androgen Receptor

Download Full-text

Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo

Oncogene ◽

10.1038/onc.2015.215 ◽

2015 ◽

Vol 35 (6) ◽

pp. 783-792 ◽

Author(s):

W Huang ◽

Z Dong ◽

Y Chen ◽

F Wang ◽

C J Wang ◽

...

Keyword(s):

Gene Expression ◽

Dna Binding ◽

Tumor Growth ◽

Small Molecule ◽

Target Gene ◽

Small Molecule Inhibitors ◽

Binding Domain ◽

Dna Binding Domain ◽

Target Gene Expression

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Molecular modeling and in vitro investigations of the human androgen receptor DNA-binding domain: application for the study of two mutations

Molecular and Cellular Endocrinology ◽

10.1016/0303-7207(95)03709-8 ◽

1996 ◽

Vol 116 (2) ◽

pp. 137-147 ◽

Author(s):

J Lobaccaro

Keyword(s):

Androgen Receptor ◽

Molecular Modeling ◽

Dna Binding ◽

Binding Domain ◽

Dna Binding Domain ◽

Human Androgen Receptor

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A ligand-dependent bipartite nuclear targeting signal in the human androgen receptor. Requirement for the DNA-binding domain and modulation by NH2-terminal and carboxyl-terminal sequences.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)36806-0 ◽

1994 ◽

Vol 269 (18) ◽

pp. 13115-13123 ◽

Author(s):

Z.X. Zhou ◽

M. Sar ◽

J.A. Simental ◽

M.V. Lane ◽

E.M. Wilson

Keyword(s):

Androgen Receptor ◽

Dna Binding ◽

Binding Domain ◽

Dna Binding Domain ◽

Nuclear Targeting ◽

Targeting Signal ◽

Carboxyl Terminal ◽

Human Androgen Receptor

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