Structure−Activity Relationship Studies Leading to the Identification of (2E)-3-[l-[(2,4-Dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide (DG-041), a Potent and Selective Prostanoid EP3 Receptor Antagonist, as a Novel Antiplatelet Agent That Does Not Prolong Bleeding

Activity Relationship ◽

Structure Activity ◽

Ep3 Receptor

Structure-activity relationship of nantenine, a novel 5-HT2A receptor antagonist and its analysis by molecular modeling

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)47568-9 ◽

2000 ◽

Vol 82 ◽

pp. 22

Author(s):

Yasushi Ohizumi-Indra ◽

Kimihiro Matsunaga ◽

Osamu Hoshino ◽

Masaji Ishiguro

Keyword(s):

Molecular Modeling ◽

Receptor Antagonist ◽

Activity Relationship ◽

Its Analysis ◽

Structure Activity ◽

Current Trends in the Structure—Activity Relationship Studies of the Endogenous Agouti-Related Protein (AGRP) Melanocortin Receptor Antagonist

ChemInform ◽

10.1002/chin.200550247 ◽

2005 ◽

Vol 36 (50) ◽

Author(s):

Andrzej M. Wilczynski ◽

Christine G. Joseph ◽

Carrie Haskell-Luevano

Keyword(s):

Receptor Antagonist ◽

Melanocortin Receptor ◽

Activity Relationship ◽

Related Protein ◽

Current Trends ◽

Structure Activity ◽

Agouti Related Protein

Structure–Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b00856 ◽

2017 ◽

Vol 60 (19) ◽

pp. 8103-8114 ◽

Cited By ~ 6

Author(s):

Mark D. Ericson ◽

Katie T. Freeman ◽

Sathya M. Schnell ◽

Katlyn A. Fleming ◽

Carrie Haskell-Luevano

Keyword(s):

Receptor Antagonist ◽

Inverse Agonist ◽

Activity Relationship ◽

Related Protein ◽

Signaling Protein ◽

Structure Activity ◽

Melanocortin 4 Receptor ◽

Agouti Related Protein

Current trends in the structure—activity relationship studies of the endogenous agouti-related protein (AGRP) melanocortin receptor antagonist

Medicinal Research Reviews ◽

10.1002/med.20037 ◽

2005 ◽

Vol 25 (5) ◽

pp. 545-556 ◽

Cited By ~ 12

Author(s):

Andrzej M. Wilczynski ◽

Christine G. Joseph ◽

Carrie Haskell-Luevano

Keyword(s):

Receptor Antagonist ◽

Melanocortin Receptor ◽

Activity Relationship ◽

Related Protein ◽

Current Trends ◽

Structure Activity ◽

Agouti Related Protein

Structure–activity relationship studies on vitamin D lactam derivatives as vitamin D receptor antagonist

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2008.06.095 ◽

2008 ◽

Vol 18 (15) ◽

pp. 4287-4290 ◽

Cited By ~ 12

Author(s):

Kaori Cho ◽

Fumito Uneuchi ◽

Yuko Kato-Nakamura ◽

Jun-ichi Namekawa ◽

Seiichi Ishizuka ◽

...

Keyword(s):

Vitamin D ◽

Receptor Antagonist ◽

Vitamin D Receptor ◽

Activity Relationship ◽

Structure Activity

Structure-activity relationship of [Nphe1 ]-NC-(1-13)-NH2 , a pure and selective nociceptin/orphanin FQ receptor antagonist

Journal of Peptide Research ◽

10.1111/j.1399-3011.2001.00820.x ◽

2001 ◽

Vol 57 (3) ◽

pp. 215-222 ◽

Cited By ~ 2

Author(s):

R. Guerrini ◽

S. Salvadori ◽

G. Calo' ◽

R. Bigoni ◽

D. Rizzi ◽

...

Keyword(s):

Receptor Antagonist ◽

Activity Relationship ◽

Orphanin Fq ◽

Structure Activity ◽

Structure–activity relationship of [Nphe1]-NC-(1-13)-NH2, a pure and selective nociceptin/orphanin FQ receptor antagonist

Journal of Peptide Research ◽

10.1034/j.1399-3011.2001.057003215.x ◽

2001 ◽

Vol 57 (3) ◽

pp. 215-222

Author(s):

R. Guerrini ◽

S. Salvadori ◽

G. Calo' ◽

R. Bigoni ◽

D. Rizzi ◽

...

Keyword(s):

Receptor Antagonist ◽

Activity Relationship ◽

Orphanin Fq ◽

Structure Activity ◽

Structure–activity relationship studies on Pd176252 derivatives leading to discovery of novel GRP receptor antagonist with potent anticancer activity

Medicinal Chemistry Research ◽

10.1007/s00044-021-02793-8 ◽

2021 ◽

Author(s):

Ming-jun Yu ◽

Chao Li ◽

Meng He ◽

Yu-ting Zhu ◽

Rui Yang ◽

...

Keyword(s):

Receptor Antagonist ◽

Anticancer Activity ◽

Activity Relationship ◽

Structure Activity ◽

Grp Receptor

Crystal structure, docking study and structure–activity relationship of carborane-containing androgen receptor antagonist 3-(12-hydroxymethyl-1,12-dicarba-closo-dodecaboran-1-yl)benzonitrile

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.04.017 ◽

2011 ◽

Vol 19 (11) ◽

pp. 3540-3548 ◽

Cited By ~ 17

Author(s):

Kiminori Ohta ◽

Tokuhito Goto ◽

Shinya Fujii ◽

Masatoshi Kawahata ◽

Akifumi Oda ◽

...

Keyword(s):

Crystal Structure ◽

Androgen Receptor ◽

Receptor Antagonist ◽

Docking Study ◽

Activity Relationship ◽

Androgen Receptor Antagonist ◽

Structure Activity ◽

Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2019.126893 ◽

2020 ◽

Vol 30 (3) ◽

pp. 126893

Author(s):

Tsuyoshi Saitoh ◽

Kazunori Seki ◽

Ryo Nakajima ◽

Naoshi Yamamoto ◽

Noriki Kutsumura ◽

...

Keyword(s):

Receptor Antagonist ◽

Activity Relationship ◽

Amino Group ◽

Structure Activity ◽

Relationship Study