Enzymes in organic synthesis: synthesis of highly enantiomerically pure 1,2-epoxy aldehydes, epoxy alcohols, thiirane, aziridine, and glyceraldehyde 3-phosphate

1990 ◽  
Vol 55 (16) ◽  
pp. 4897-4901 ◽  
Author(s):  
Richard L. Pederson ◽  
Kevin K. C. Liu ◽  
James F. Rutan ◽  
Lihren Chen ◽  
Chi Huey Wong
Keyword(s):  
Organic Synthesis ◽  
Enantiomerically Pure ◽  
Epoxy Alcohols ◽  
Enzymes In Organic Synthesis

Enzymes in organic synthesis. 32. Stereospecific horse liver alcohol dehydrogenase-catalyzed oxidations of exo- and endo-oxabicyclic meso diols

1984 ◽  
Vol 62 (11) ◽  
pp. 2578-2582 ◽  
Author(s):  
J. Bryan Jones ◽  
Christopher J. Francis
Keyword(s):  
Alcohol Dehydrogenase ◽  
Organic Synthesis ◽  
Horse Liver Alcohol Dehydrogenase ◽  
Preparative Scale ◽  
Enantiomerically Pure ◽  
Liver Alcohol Dehydrogenase ◽  
Horse Liver ◽  
One Step ◽  
Catalyzed Oxidation ◽  
Enzymes In Organic Synthesis

Preparative-scale horse liver alcohol dehydrogenase-catalyzed oxidation of mesoexo- and endo-7-oxabicyclo[2.2.1]heptane diols provides a direct one-step route to enantiomerically pure chiral γ-lactones of the oxabicyclic series.

Enzymes in organic synthesis. 26.Synthesis of enantiomerically pure grandisol from an enzyme-generated chiral synthon

1982 ◽  
Vol 60 (15) ◽  
pp. 2007-2011 ◽  
Author(s):  
J. Bryan Jones ◽  
Mark A. W. Finch ◽  
Ignac J. Jakovac
Keyword(s):  
Organic Synthesis ◽  
Pure Material ◽  
Enantiomerically Pure ◽  
Optically Pure ◽  
Enzymes In Organic Synthesis ◽  
Chiral Synthon

The synthesis of enantiomerically pure (+)-grandisol has been achieved from an enzymically generated chiral synthon. The synthesis is an efficient one, the yield of optically pure material being 12% up to the penultimate step and 3% overall.

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