Design and Synthesis of Transition State Analogs for Induction of Hydride Transfer Catalytic Antibodies

1997 ◽  
Vol 62 (10) ◽  
pp. 3220-3229 ◽  
Author(s):  
Josef Schröer ◽  
Michel Sanner ◽  
Jean-Louis Reymond
Keyword(s):  
Transition State ◽  
Hydride Transfer ◽  
Catalytic Antibodies ◽  
Design And Synthesis ◽  
Transition State Analogs

Comparison of phosphonate transition state analogs for inducing catalytic antibodies and evaluation of key structural factors by an ab initio study

Tetrahedron ◽  
1999 ◽  
Vol 55 (9) ◽  
pp. 2559-2572 ◽  
Author(s):  
Hiroyuki Kakinuma ◽  
Kazuko Shimazaki ◽  
Naoko Takahashi ◽  
Kyoko Takahashi ◽  
Shigeo Niihata ◽  
...  
Keyword(s):  
Transition State ◽  
Ab Initio ◽  
Catalytic Antibodies ◽  
Structural Factors ◽  
Ab Initio Study ◽  
Transition State Analogs

scholarly journals Design, Synthesis, and Evaluation of Transition-State Analogs as Inhibitors of the Bacterial Quorum Sensing Autoinducer Synthase CepI

2020 ◽  
Author(s):  
Erin Higgins ◽  
Julian Kellner-Rogers ◽  
Alexandra Estanislau ◽  
Alec Esposito ◽  
Nora R. Vail ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Transition State ◽  
Enzymatic Reaction ◽  
Signal Molecules ◽  
Antibacterial Drug ◽  
Dependent Manner ◽  
Human Pathogens ◽  
Design Synthesis ◽  
Design And Synthesis ◽  
Transition State Analogs

<p></p><p>Quorum sensing is a bacterial signaling system that involves the synthesis and detection of small signal molecules called autoinducers. A main class of autoinducers in Gram-negative bacteria are acylated homoserine lactones, produced by the LuxI family of autoinducer synthase enzymes and detected by the LuxR family of autoinducer receptors. Quorum sensing allows for changes in gene expression and bacterial behaviors in a coordinated, cell density dependent manner. Quorum sensing controls the expression of virulence factors in some human pathogens, making quorum sensing an antibacterial drug target. Here we describe the design and synthesis of transition-state analogs of the autoinducer synthase enzymatic reaction and evaluation of these compounds as inhibitors of the synthase CepI. One such compound potently inhibits CepI and constitutes a new type of inhibitor against this underdeveloped antibacterial target.</p><br><p></p>

scholarly journals Generation of Polyclonal Catalytic Antibodies Against Cocaine Using Transition State Analogs of Cocaine Conjugated to Diphtheria Toxoid.

1995 ◽  
Vol 43 (11) ◽  
pp. 1902-1911 ◽  
Author(s):  
Garo P. BASMADJIAN ◽  
Satendra SINGH ◽  
Budiono SASTRODJOJO ◽  
Blaine T. SMITH ◽  
Kwasi AVOR ◽  
...  
Keyword(s):  
Transition State ◽  
Catalytic Antibodies ◽  
Diphtheria Toxoid ◽  
Transition State Analogs

Design and synthesis of histone deacetylase inhibitors: the development of apicidin transition state analogs

2000 ◽  
Vol 41 (41) ◽  
pp. 7837-7841 ◽  
Author(s):  
Steven L Colletti ◽  
Robert W Myers ◽  
Sandra J Darkin-Rattray ◽  
Dennis M Schmatz ◽  
Michael H Fisher ◽  
...  
Keyword(s):  
Transition State ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Design And Synthesis ◽  
Transition State Analogs

scholarly journals Design, Synthesis, and Evaluation of Transition-State Analogs as Inhibitors of the Bacterial Quorum Sensing Autoinducer Synthase CepI

2020 ◽  
Author(s):  
Erin Higgins ◽  
Julian Kellner-Rogers ◽  
Alexandra Estanislau ◽  
Alec Esposito ◽  
Nora R. Vail ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Transition State ◽  
Enzymatic Reaction ◽  
Signal Molecules ◽  
Antibacterial Drug ◽  
Dependent Manner ◽  
Human Pathogens ◽  
Design Synthesis ◽  
Design And Synthesis ◽  
Transition State Analogs

<p></p><p>Quorum sensing is a bacterial signaling system that involves the synthesis and detection of small signal molecules called autoinducers. A main class of autoinducers in Gram-negative bacteria are acylated homoserine lactones, produced by the LuxI family of autoinducer synthase enzymes and detected by the LuxR family of autoinducer receptors. Quorum sensing allows for changes in gene expression and bacterial behaviors in a coordinated, cell density dependent manner. Quorum sensing controls the expression of virulence factors in some human pathogens, making quorum sensing an antibacterial drug target. Here we describe the design and synthesis of transition-state analogs of the autoinducer synthase enzymatic reaction and evaluation of these compounds as inhibitors of the synthase CepI. One such compound potently inhibits CepI and constitutes a new type of inhibitor against this underdeveloped antibacterial target.</p><br><p></p>

scholarly journals Design, Synthesis, and Evaluation of Transition-State Analogs as Inhibitors of the Bacterial Quorum Sensing Autoinducer Synthase CepI

2020 ◽  
Author(s):  
Erin Higgins ◽  
Julian Kellner-Rogers ◽  
Alexandra Estanislau ◽  
Alec Esposito ◽  
Nora R. Vail ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Transition State ◽  
Enzymatic Reaction ◽  
Signal Molecules ◽  
Design Synthesis ◽  
Design And Synthesis ◽  
Transition State Analogs ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum ◽  
Antibacterial Target

<p>Quorum sensing is a bacterial signaling system that involves the synthesis and subsequent detection of small signal molecules called autoinducers. The main autoinducer in gram-negative bacteria are acylated homoserine lactones (AHLs), produced by LuxI autoinducer synthase enzymes and detected by LuxR autoinducer receptors. Quorum sensing allows for changes in gene expression resulting bacterial behavior in a coordinated, cell-density dependent fashion. Some of the behaviors controlled by quorum sensing involve pathogenesis, making quorum sensing signaling a target to develop new antibacterial agents. Here we describe the design and synthesis of transition-state analogs of the autoinducer synthase enzymatic reaction and the evaluation of these compounds as inhibitors of the synthase CepI. One such compound potently inhibits CepI and constitutes a new type of inhibitor against this underdeveloped antibacterial target.</p>

Sign in / Sign up

Export Citation Format

Share Document