Ethnobotanical Drug Discovery Based on Medicine Men's Trials in the African Savanna: Screening of East African Plants for Antimicrobial Activity II

1993 ◽  
Vol 56 (9) ◽  
pp. 1539-1546 ◽  
Author(s):  
Makoto Taniguchi ◽  
Isao Kubo
Keyword(s):  
Antimicrobial Activity ◽  
Drug Discovery ◽  
East African ◽  
African Savanna ◽  
African Plants

scholarly journals Screening of east African plants for antimicrobial activity. I.

1978 ◽  
Vol 26 (9) ◽  
pp. 2910-2913 ◽  
Author(s):  
MAKOTO TANIGUCHI ◽  
ANDREW CHAPYA ◽  
ISAO KUBO ◽  
KOJI NAKANISHI
Keyword(s):  
Antimicrobial Activity ◽  
East African ◽  
African Plants

Design, Synthesis and Docking Studies of Some Novel Fluoroquinolone Compounds with Antibacterial Activity

2018 ◽  
Vol 69 (4) ◽  
pp. 815-822 ◽  
Author(s):  
Lucia Pintilie ◽  
Amalia Stefaniu ◽  
Alina Ioana Nicu ◽  
Maria Maganu ◽  
Miron Teodor Caproiu
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Molecular Docking ◽  
Drug Discovery ◽  
Elemental Analysis ◽  
Docking Studies ◽  
Receptor Protein ◽  
Chemical Methods ◽  
Design Synthesis ◽  
Gram Negative

A new series of fluoroquinolone compounds have been obtained by Gould-Jacobs method. The compounds have been characterized by physic-chemical methods (elemental analysis, FTIR, NMR, UV-Vis) and by antimicrobial activity against Gram-positive and Gram-negative microorganisms. For the synthesized compounds have been performed calculations of characteristics and molecular properties, using Spartan�14 Software from Wavefunction, Inc. Irvine, CA. and molecular docking studies using CLC Drug Discovery Workbench 2.4 software, to identify and visualize the most likely interaction ligand (fluoroquinolone) with the receptor protein.

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