Total Synthesis of the Interleukin-1β Converting Enzyme Inhibitor EI-1941-2 Using Tandem Oxa-electrocyclization/Oxidation1

2006 ◽  
Vol 8 (13) ◽  
pp. 2847-2850 ◽  
Author(s):  
Andrew S. Kleinke ◽  
Chaomin Li ◽  
Nicolas Rabasso ◽  
John A. Porco
2000 ◽  
Vol 279 (4) ◽  
pp. R1512-R1516 ◽  
Author(s):  
Tatsuo Watanabe ◽  
Makoto Hashimoto ◽  
Minoru Wada ◽  
Toshiaki Imoto ◽  
Michio Miyoshi ◽  
...  

It has been reported that a host develops a marked fever under dehydrated conditions compared with normally hydrated conditions (11). The present study was carried out to investigate whether ANG II is involved in the enhancement seen in dehydrated rats of the fever induced by bacterial endotoxin. The results showed that intravenous injection of bacterial endotoxin produced a fever in dehydrated rats (rats deprived of water for 24 h) that was significantly greater than that seen in normally hydrated rats. In contrast, dehydration had no effect on the fever induced by intravenous interleukin-1β (IL-1β). Under dehydrated conditions, the enhanced endotoxin-induced fever was significantly inhibited by the angiotensin-converting enzyme inhibitor lisinopril, but the IL-1β fever was not. These results suggest that the dehydration-induced enhancement of endotoxin fever is due, at least in part, to the action of ANG II, which elicits an increased production of pyrogenic cytokines such as IL-1.


1997 ◽  
Vol 40 (13) ◽  
pp. 1941-1946 ◽  
Author(s):  
Roland E. Dolle ◽  
C. V. C. Prasad ◽  
Catherine P. Prouty ◽  
Joseph M. Salvino ◽  
Mohamed M. A. Awad ◽  
...  

ChemInform ◽  
2004 ◽  
Vol 35 (42) ◽  
Author(s):  
Fumito Koizumi ◽  
Atsuhiro Hasegawa ◽  
Mayumi Yoshida ◽  
Yuzuru Matsuda ◽  
Satoshi Nakanishi

ChemInform ◽  
2004 ◽  
Vol 35 (18) ◽  
Author(s):  
Fumito Koizumi ◽  
Tsutomu Agatsuma ◽  
Katsuhiko Ando ◽  
Hidemasa Kondo ◽  
Yutaka Saitoh ◽  
...  

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