Application of Ruthenium Complexes of Triazole-Containing Tridentate Ligands to Asymmetric Transfer Hydrogenation of Ketones

AbstractChiral aminosulfonamides containing imidazolium group were used as ligands for the ruthenium(II)-catalyzed asymmetric transfer hydrogenation of prochiral ketones in ionic liquid, affording good to excellent conversions and enantiomeric excesses. The catalytic system could be easily recovered and reused several times.

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ChemInform Abstract: Highly Diastereoselective Formation of Ruthenium Complexes for Efficient Catalytic Asymmetric Transfer Hydrogenation.

ChemInform ◽

10.1002/chin.200803062 ◽

2008 ◽

Vol 39 (3) ◽

Author(s):

Walter Baratta ◽

Giorgio Chelucci ◽

Eberhardt Herdtweck ◽

Santo Magnolia ◽

Katia Siega ◽

...

Keyword(s):

Ruthenium Complexes ◽

Transfer Hydrogenation ◽

Asymmetric Transfer Hydrogenation ◽

Catalytic Asymmetric

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ChemInform Abstract: Ruthenium Complexes for Asymmetric Transfer Hydrogenation

ChemInform ◽

10.1002/chin.201110250 ◽

2011 ◽

Vol 42 (10) ◽

pp. no-no

Author(s):

Petr Kacer ◽

Marek Kuzma ◽

Eliska Leitmannova ◽

Libor Cerveny

Keyword(s):

Ruthenium Complexes ◽

Transfer Hydrogenation ◽

Asymmetric Transfer Hydrogenation

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Ruthenium complexes of P-stereogenic phosphines with a heterocyclic substituent

Dalton Transactions ◽

10.1039/c6dt00995f ◽

2016 ◽

Vol 45 (20) ◽

pp. 8513-8531 ◽

Cited By ~ 12

Author(s):

Pau Clavero ◽

Arnald Grabulosa ◽

Mercè Rocamora ◽

Guillermo Muller ◽

Mercè Font-Bardia

Keyword(s):

Ruthenium Complexes ◽

Transfer Hydrogenation ◽

Asymmetric Transfer Hydrogenation ◽

Hydrogenation Reactions ◽

Heterocyclic Substituent ◽

Optically Pure

Optically pure P-stereogenic monophosphorus ligands containing a heterocyclic substituent have been prepared. They have been coordinated to Ru-η6-arene moieties in which the ligands act as mono- or bidentate. The complexes catalyse asymmetric transfer hydrogenation reactions with up to 70% ee.

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Asymmetric Hydrogenation of Trifluoromethyl Ketones: Application in the Synthesis of Odanacatib and LX-1031

Organic Chemistry Frontiers ◽

10.1039/d1qo00368b ◽

2021 ◽

Author(s):

Tiao-Zhen Zhu ◽

Pan-Lin Shao ◽

Xumu Zhang

Keyword(s):

Asymmetric Hydrogenation ◽

Transfer Hydrogenation ◽

Asymmetric Transfer Hydrogenation ◽

Tridentate Ligands ◽

Iridium Catalysis ◽

Trifluoromethyl Ketones ◽

Stereoelectronic Properties

Due to their stereoelectronic properties, trifluoromethyl (or perfluoroalkyl) ketones are challenging substrates in asymmetric (transfer) hydrogenation. We developed iridium catalysis bearing ferrocene-based tridentate ligands (f-amphol or f-ampha), offering a promising...

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