Asymmetric Synthesis of Trisubstituted Tetrahydrothiophenes Bearing a Quaternary Stereocenter via Double Michael Reaction Involving Dynamic Kinetic Resolution

2013 ◽  
Vol 15 (13) ◽  
pp. 3436-3439 ◽  
Author(s):  
Sara Meninno ◽  
Gianluca Croce ◽  
Alessandra Lattanzi
Keyword(s):  
Asymmetric Synthesis ◽  
Kinetic Resolution ◽  
Michael Reaction ◽  
Dynamic Kinetic Resolution ◽  
Quaternary Stereocenter

Asymmetric Synthesis of a Key Intermediate for Tofacitinib via a Dynamic Kinetic Resolution-Reductive Amination Protocol

2018 ◽  
Vol 22 (12) ◽  
pp. 1817-1822 ◽  
Author(s):  
Gerard K. M. Verzijl ◽  
Christian Schuster ◽  
Thomas Dax ◽  
André H. M. de Vries ◽  
Laurent Lefort
Keyword(s):  
Asymmetric Synthesis ◽  
Reductive Amination ◽  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution

Asymmetric Synthesis of Antithrombotic Agents M58163 and M58169: Dynamic Kinetic Resolution in Amide Formation Catalyzed by La-Linked BINOL Complex

2006 ◽  
Vol 2006 (24) ◽  
pp. 5454-5457 ◽  
Author(s):  
Fumihiko Saitoh ◽  
Hidemitsu Nishida ◽  
Takafumi Mukaihira ◽  
Kohsuke Aikawa ◽  
Koichi Mikami
Keyword(s):  
Asymmetric Synthesis ◽  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution ◽  
Antithrombotic Agents ◽  
Amide Formation

Interplay of Direct Stereocontrol and Dynamic Kinetic Resolution in a Bifunctional Amine Thiourea Catalyzed Highly Enantioselective Cascade Michael-Michael Reaction

2010 ◽  
Vol 17 (3) ◽  
pp. 770-774 ◽  
Author(s):  
Chenguang Yu ◽  
Yinan Zhang ◽  
Aiguo Song ◽  
Yafei Ji ◽  
Wei Wang
Keyword(s):  
Kinetic Resolution ◽  
Michael Reaction ◽  
Dynamic Kinetic Resolution

Brønsted Acid-catalyzed Dynamic Kinetic Resolution of in situ Formed Acyclic N,O-hemiaminals: Cascade Synthesis of Chiral Cyclic N,O-aminals

2021 ◽  
Author(s):  
Xue-Jiao Lv ◽  
Yong-Chao Ming ◽  
Hui-Chun Wu ◽  
Yankai Liu
Keyword(s):  
Kinetic Resolution ◽  
Michael Reaction ◽  
Amide Group ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Dynamic Kinetic Resolution ◽  
Brönsted Acid ◽  
Acid Catalyzed

A Brønsted acid-catalyzed cascade acyclic N,O-hemiaminal formation/oxa-Michael reaction is developed for the synthesis of cis-2,6-disubstituted tetrahydropyrans bearing an exo amide group, that is, cyclic N,O-aminals. By using TsOH, various different...

Asymmetric Synthesis of QUINAP via Dynamic Kinetic Resolution

2013 ◽  
Vol 135 (45) ◽  
pp. 16829-16832 ◽  
Author(s):  
Vikram Bhat ◽  
Su Wang ◽  
Brian M. Stoltz ◽  
Scott C. Virgil
Keyword(s):  
Asymmetric Synthesis ◽  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution

Dynamic Kinetic Resolution for Asymmetric Synthesis of L-Noncanonical Amino Acids from D-Ser Using Tryptophan Synthase and Alanine Racemase

2019 ◽  
Vol 2019 (39) ◽  
pp. 6618-6625 ◽  
Author(s):  
Jinhai Yu ◽  
Jing Li ◽  
Xia Gao ◽  
Shuiyun Zeng ◽  
Hongjuan Zhang ◽  
...  
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
Kinetic Resolution ◽  
Alanine Racemase ◽  
Tryptophan Synthase ◽  
Dynamic Kinetic Resolution ◽  
Noncanonical Amino Acids

A new cost-effective Ru-chloramphenicol base derivative catalyst for the asymmetric transfer hydrogenation/dynamic kinetic resolution of N-Boc α-amino-β-ketoesters and its application to the synthesis of the chiral core of vancomycin

RSC Advances ◽  
2016 ◽  
Vol 6 (44) ◽  
pp. 37701-37709 ◽  
Author(s):  
Xinlong Wang ◽  
Lingjun Xu ◽  
Fangjun Xiong ◽  
Yan Wu ◽  
Fener Chen
Keyword(s):  
Asymmetric Synthesis ◽  
Kinetic Resolution ◽  
Cost Effective ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Dynamic Kinetic Resolution ◽  
Amino Esters ◽  
Base Derivative

Herein we describe the application of Ru-chloramphenicol base complexes catalyzed highly diastereo- and enantioselective transfer hydrogenation of N-Boc α-amino-β-ketoesters for the asymmetric synthesis of anti-N-Boc-β-hydroxy-α-amino esters.

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