Abstract::
Minisci-type reactions have become widely known as reactions that involve the addition of carbon-centered
radicals to basic heteroarenes followed by formal hydrogen atom loss. While the originally developed protocols for radical
generation remain in active use today, in recent years by a new array of radical generation strategies allow use of a wider
variety of radical precursors that often operate under milder and more benign conditions. New transformations based on free
radical reactivity are now available to a synthetic chemist looking to utilize a Minisci-type reaction. Radical-generation
methods based on photoredox catalysis and electrochemistry, which utilize thermal cleavage or the in situ generation of
reactive radical precursors, have become popular approaches. Our review will cover the remarkably literature that has
appeared on this topic in recent 5 years, from 2015-01 to 2020-01, in an attempt to provide guidance to the synthetic
chemist, on both the challenges that have been overcome and applications in organic synthesis.
Cover Feature: In Situ Generation of Ruthenium Carbonyl Phosphine Complexes as a Versatile Method for the Development of Enantioselective C−O Bond Arylation (Chem. Eur. J. 8/2020)
