An Efficient and Scalable Synthesis of the Endothelin Antagonists UK-350,926 and UK-349,862 Using a Dynamic Resolution Process

2005 ◽  
Vol 9 (5) ◽  
pp. 663-669 ◽  
Author(s):  
Christopher P. Ashcroft ◽  
Stephen Challenger ◽  
David Clifford ◽  
Andrew M. Derrick ◽  
Yousef Hajikarimian ◽  
...  
Keyword(s):  
Resolution Process ◽  
Endothelin Antagonists ◽  
Dynamic Resolution ◽  
Scalable Synthesis

ChemInform Abstract: Synthesis of Homochiral L-(S)-tert-Leucine via a Lipase-Catalyzed Dynamic Resolution Process.

ChemInform ◽  
2010 ◽  
Vol 26 (25) ◽  
pp. no-no ◽  
Author(s):  
N. J. TURNER ◽  
J. R. WINTERMAN ◽  
R. MCCAGUE ◽  
J. S. PARRATT ◽  
S. J. C. TAYLOR
Keyword(s):  
Resolution Process ◽  
Dynamic Resolution

Synthesis of homochiral l-(S)-tert-leucine via a lipase catalysed dynamic resolution process

1995 ◽  
Vol 36 (7) ◽  
pp. 1113-1116 ◽  
Author(s):  
Nicholas J. Turner ◽  
James R. Winterman ◽  
Raymond McCague ◽  
Julian S. Parratt ◽  
Stephen J.C. Taylor
Keyword(s):  
Resolution Process ◽  
Dynamic Resolution

Differential Effects of Prior Experience on the Malware Resolution Process

MIS Quarterly ◽  
2014 ◽  
Vol 38 (3) ◽  
pp. 655-678 ◽  
Author(s):  
Seung Hyun Kim ◽  
◽  
Byung Cho Kim ◽  
◽  
Keyword(s):  
Prior Experience ◽  
Differential Effects ◽  
Resolution Process

Scalable Synthesis of Functionalized Ferrocenyl Azides and Amines Enabled by Flow Chemistry

2019 ◽  
Author(s):  
Merlin Kleoff ◽  
Johannes Schwan ◽  
Lisa Boeser ◽  
Bence Hartmayer ◽  
Mathias Christmann ◽  
...  
Keyword(s):  
Reaction Time ◽  
Heterogeneous Reaction ◽  
Reduction Process ◽  
Flow Chemistry ◽  
Subsequent Reaction ◽  
Scalable Synthesis ◽  
High Yields ◽  
Reactor Section

A scalable access to functionalized 1,1’- and 1,2-ferrocenyl azides has been realized in flow. By halogen‒lithium exchange of ferrocenyl halides and subsequent reaction with tosyl azide, a variety of functionalized ferrocenyl azides was obtained in high yields. To allow a scalable preparation of these potentially explosive compounds, an efficient flow protocol was developed accelerating the reaction time to minutes and circumventing accumulation of potentially hazardous intermediates. Switching from homogeneous to triphasic flow amidst process was key for handling a heterogeneous reaction mixture formed after a heated reactor section. The corresponding and synthetically versatile ferrocenyl amines were then prepared by a reliable reduction process.

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