Process Research on the Asymmetric Hydrogenation of a Benzophenone for Developing the Manufacturing Process of the Squalene Synthase Inhibitor TAK-475

2011 ◽  
Vol 15 (5) ◽  
pp. 1178-1184 ◽  
Author(s):  
Mitsutaka Goto ◽  
Takahiro Konishi ◽  
Shinji Kawaguchi ◽  
Masatoshi Yamada ◽  
Toshiaki Nagata ◽  
...  
Keyword(s):  
Manufacturing Process ◽  
Asymmetric Hydrogenation ◽  
Process Research ◽  
Squalene Synthase ◽  
Synthase Inhibitor ◽  
Squalene Synthase Inhibitor

ChemInform Abstract: Absolute Stereochemistry of the Squalene Synthase Inhibitor Zaragozic Acid C (I).

ChemInform ◽  
2010 ◽  
Vol 25 (39) ◽  
pp. no-no
Author(s):  
C. SANTINI ◽  
R. G. BALL ◽  
G. D. BERGER
Keyword(s):  
Squalene Synthase ◽  
Zaragozic Acid ◽  
Synthase Inhibitor ◽  
Absolute Stereochemistry ◽  
Squalene Synthase Inhibitor ◽  
Zaragozic Acid C

scholarly journals Correction to “Discovery of DF-461, a Potent Squalene Synthase Inhibitor”

2014 ◽  
Vol 5 (6) ◽  
pp. 722-722
Author(s):  
Masanori Ichikawa ◽  
Masami Ohtsuka ◽  
Hitoshi Ohki ◽  
Masahiro Ota ◽  
Noriyasu Haginoya ◽  
...  
Keyword(s):  
Squalene Synthase ◽  
Synthase Inhibitor ◽  
Squalene Synthase Inhibitor

Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C by a Carbonyl Ylide Cycloaddition Strategy

2003 ◽  
Vol 115 (43) ◽  
pp. 5509-5513 ◽  
Author(s):  
Seiichi Nakamura ◽  
Yuuki Hirata ◽  
Takahiro Kurosaki ◽  
Masahiro Anada ◽  
Osamu Kataoka ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Squalene Synthase ◽  
Carbonyl Ylide ◽  
Zaragozic Acid ◽  
Synthase Inhibitor ◽  
Squalene Synthase Inhibitor ◽  
Zaragozic Acid C

Lipid-lowering effects of TAK-475, a squalene synthase inhibitor, in animal models of familial hypercholesterolemia

2003 ◽  
Vol 466 (1-2) ◽  
pp. 155-161 ◽  
Author(s):  
Yuichiro Amano ◽  
Tomoyuki Nishimoto ◽  
Ryu-ichi Tozawa ◽  
Eiichiro Ishikawa ◽  
Yoshimi Imura ◽  
...  
Keyword(s):  
Animal Models ◽  
Familial Hypercholesterolemia ◽  
Squalene Synthase ◽  
Lipid Lowering ◽  
Synthase Inhibitor ◽  
Squalene Synthase Inhibitor

We-S13:3 Stabilization of coronary atherosclerosis by a squalene synthase inhibitor

2006 ◽  
Vol 7 (3) ◽  
pp. 339 ◽  
Author(s):  
M. Shiomi ◽  
S. Yamada ◽  
Y. Amano ◽  
T. Nishimoto ◽  
T. Ito
Keyword(s):  
Coronary Atherosclerosis ◽  
Squalene Synthase ◽  
Synthase Inhibitor ◽  
Squalene Synthase Inhibitor

Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs

2007 ◽  
Vol 223 (1) ◽  
pp. 39-45 ◽  
Author(s):  
Tomoyuki Nishimoto ◽  
Eiichiro Ishikawa ◽  
Hisashi Anayama ◽  
Hitomi Hamajyo ◽  
Hirofumi Nagai ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Squalene Synthase ◽  
Protective Effects ◽  
Synthase Inhibitor ◽  
Squalene Synthase Inhibitor

P4-328 The squalene synthase inhibitor RPR 107393A reduces Aβ peptide level in an APP transgenic mouse model

2004 ◽  
Vol 25 ◽  
pp. S568
Author(s):  
Laurent Pradier ◽  
Thierry Canton ◽  
Zakia Bouaiche ◽  
Patrick Benoit ◽  
Jesus Benavides
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Squalene Synthase ◽  
Aβ Peptide ◽  
Peptide Level ◽  
Synthase Inhibitor ◽  
Squalene Synthase Inhibitor

Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C by a Carbonyl Ylide Cycloaddition Strategy.

ChemInform ◽  
2004 ◽  
Vol 35 (11) ◽  
Author(s):  
Seiichi Nakamura ◽  
Yuuki Hirata ◽  
Takahiro Kurosaki ◽  
Masahiro Anada ◽  
Osamu Kataoka ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Squalene Synthase ◽  
Carbonyl Ylide ◽  
Zaragozic Acid ◽  
Synthase Inhibitor ◽  
Squalene Synthase Inhibitor ◽  
Zaragozic Acid C

scholarly journals Effect of YM-53601, a novel squalene synthase inhibitor, on the clearance rate of plasma LDL and VLDL in hamsters

2002 ◽  
Vol 137 (4) ◽  
pp. 561-567 ◽  
Author(s):  
Tohru Ugawa ◽  
Hirotoshi Kakuta ◽  
Hiroshi Moritani ◽  
Osamu Inagaki
Keyword(s):  
Clearance Rate ◽  
Squalene Synthase ◽  
Synthase Inhibitor ◽  
Squalene Synthase Inhibitor

Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C by a Carbonyl Ylide Cycloaddition Strategy

2003 ◽  
Vol 42 (43) ◽  
pp. 5351-5355 ◽  
Author(s):  
Seiichi Nakamura ◽  
Yuuki Hirata ◽  
Takahiro Kurosaki ◽  
Masahiro Anada ◽  
Osamu Kataoka ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Squalene Synthase ◽  
Carbonyl Ylide ◽  
Zaragozic Acid ◽  
Synthase Inhibitor ◽  
Squalene Synthase Inhibitor ◽  
Zaragozic Acid C
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