Proteomics Approach to Identify the Interacting Partners of Cellular Prion Protein and Characterization of Rab7a Interaction in Neuronal Cells

2011 ◽  
Vol 10 (7) ◽  
pp. 3123-3135 ◽  
Author(s):  
Saima Zafar ◽  
Nicolas von Ahsen ◽  
Michael Oellerich ◽  
Inga Zerr ◽  
Walter J. Schulz-Schaeffer ◽  
...  
Keyword(s):  
Prion Protein ◽  
Neuronal Cells ◽  
Cellular Prion Protein ◽  
Proteomics Approach

scholarly journals The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein

2007 ◽  
Vol 402 (1) ◽  
pp. 17-23 ◽  
Author(s):  
David R. Taylor ◽  
Nigel M. Hooper
Keyword(s):  
Prion Protein ◽  
Low Density Lipoprotein ◽  
Neuronal Cells ◽  
Ldl Receptor ◽  
Density Lipoprotein ◽  
Adaptor Protein ◽  
Cellular Prion Protein ◽  
Low Density ◽  
Related Protein ◽  
Density Lipoprotein Receptor

PrPC (cellular prion protein) is located at the surface of neuronal cells in detergent-insoluble lipid rafts, yet is internalized by clathrin-dependent endocytosis. As PrPC is glycosyl-phosphatidylinositol-anchored, it requires a transmembrane adaptor protein to connect it to the clathrin endocytosis machinery. Using receptor-associated protein and small interfering RNA against particular LDL (low-density lipoprotein) family members, in combination with immunofluorescence microscopy and surface biotinylation assays, we show that the transmembrane LRP1 (LDL receptor-related protein 1) is required for the Cu2+-mediated endocytosis of PrPC in neuronal cells. We show also that another LRP1 ligand that can cause neurodegenerative disease, the Alzheimer's amyloid precursor protein, does not modulate the endocytosis of PrPC.

scholarly journals Characterization of Detergent-insoluble Complexes Containing the Cellular Prion Protein and Its Scrapie Isoform

1997 ◽  
Vol 272 (10) ◽  
pp. 6324-6331 ◽  
Author(s):  
Naava Naslavsky ◽  
Ronit Stein ◽  
Anat Yanai ◽  
Gilgi Friedlander ◽  
Albert Taraboulos
Keyword(s):  
Prion Protein ◽  
Cellular Prion Protein

Cellular Prion Protein Signaling in Serotonergic Neuronal Cells

2007 ◽  
Vol 1096 (1) ◽  
pp. 106-119 ◽  
Author(s):  
S. MOUILLET-RICHARD ◽  
B. SCHNEIDER ◽  
E. PRADINES ◽  
M. PIETRI ◽  
M. ERMONVAL ◽  
...  
Keyword(s):  
Prion Protein ◽  
Neuronal Cells ◽  
Cellular Prion Protein ◽  
Protein Signaling

The involvement of cellular prion protein in the autophagy pathway in neuronal cells

2008 ◽  
Vol 39 (2) ◽  
pp. 238-247 ◽  
Author(s):  
Jae-Min Oh ◽  
Hae-Young Shin ◽  
Seok-Joo Park ◽  
Boe-Hyun Kim ◽  
Jin-Kyu Choi ◽  
...  
Keyword(s):  
Prion Protein ◽  
Neuronal Cells ◽  
Cellular Prion Protein ◽  
Autophagy Pathway

scholarly journals Cellular prion protein (PrPC) protects neuronal cells from the effect of huntingtin aggregation

2007 ◽  
Vol 120 (15) ◽  
pp. 2663-2671 ◽  
Author(s):  
K.-J. Lee ◽  
A. Panzera ◽  
D. Rogawski ◽  
L. E. Greene ◽  
E. Eisenberg
Keyword(s):  
Prion Protein ◽  
Neuronal Cells ◽  
Cellular Prion Protein

scholarly journals Cellular Prion Protein Combined with Galectin-3 and -6 Affects the Infectivity Titer of an Endogenous Retrovirus Assayed in Hippocampal Neuronal Cells

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0167293 ◽  
Author(s):  
Boe-Hyun Kim ◽  
Hae-Young Shin ◽  
Joy J. Goto ◽  
Richard I. Carp ◽  
Eun-Kyoung Choi ◽  
...  
Keyword(s):  
Prion Protein ◽  
Neuronal Cells ◽  
Endogenous Retrovirus ◽  
Cellular Prion Protein ◽  
Galectin 3 ◽  
Infectivity Titer

Production and Characterization of a Panel of Monoclonal Antibodies Against Native Human Cellular Prion Protein

Hybridoma ◽  
2009 ◽  
Vol 28 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Michael Jones ◽  
Victoria McLoughlin ◽  
John G. Connolly ◽  
Christine F. Farquhar ◽  
Ian R. MacGregor ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Prion Protein ◽  
Cellular Prion Protein

scholarly journals Clustering of cellular prion protein induces ERK1/2 and stathmin phosphorylation in GT1-7 neuronal cells

FEBS Letters ◽  
2004 ◽  
Vol 576 (1-2) ◽  
pp. 114-118 ◽  
Author(s):  
Céline Monnet ◽  
Julie Gavard ◽  
René-Marc Mège ◽  
André Sobel
Keyword(s):  
Prion Protein ◽  
Neuronal Cells ◽  
Cellular Prion Protein

scholarly journals Cellular prion protein coupling to TACE-dependent TNF-α shedding controls neurotransmitter catabolism in neuronal cells

2009 ◽  
Vol 110 (3) ◽  
pp. 912-923 ◽  
Author(s):  
Elodie Pradines ◽  
Damien Loubet ◽  
Sophie Mouillet-Richard ◽  
Philippe Manivet ◽  
Jean-Marie Launay ◽  
...  
Keyword(s):  
Prion Protein ◽  
Neuronal Cells ◽  
Cellular Prion Protein ◽  
Protein Coupling ◽  
Tnf Α
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