Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Acrylamide and Its Metabolites in Mice, Rats, and Humans

Chemical Research in Toxicology ◽

10.1021/tx600287w ◽

2007 ◽

Vol 20 (3) ◽

pp. 388-399 ◽

Author(s):

John F. Young ◽

Richard H. Luecke ◽

Daniel R. Doerge

Keyword(s):

Pharmacodynamic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Development of a physiologically based pharmacokinetic/pharmacodynamic model to identify mechanisms contributing to entacapone low bioavailability

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.1986 ◽

2015 ◽

Vol 36 (9) ◽

pp. 587-602 ◽

Author(s):

Saeed Alqahtani ◽

Amal Kaddoumi

Keyword(s):

Pharmacodynamic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Guiding dose adjustment of amlodipine after co-administration with ritonavir containing regimens using a physiologically-based pharmacokinetic/pharmacodynamic model

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-018-9574-0 ◽

2018 ◽

Vol 45 (3) ◽

pp. 443-456 ◽

Author(s):

Dwaipayan Mukherjee ◽

Jiuhong Zha ◽

Rajeev M. Menon ◽

Mohamad Shebley

Keyword(s):

Dose Adjustment ◽

Pharmacodynamic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropyfluorophosphate

Toxicology and Applied Pharmacology ◽

10.1016/0041-008x(90)90249-t ◽

1990 ◽

Vol 106 (2) ◽

pp. 295-310 ◽

Author(s):

Jeffery M. Gearhart ◽

Gary W. Jepson ◽

Harvey J. Clewell ◽

Melvin E. Andersen ◽

Rory B. Conolly

Keyword(s):

Pharmacodynamic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Use of a physiologically based pharmacokinetic–pharmacodynamic model for initial dose prediction and escalation during a paediatric clinical trial

British Journal of Clinical Pharmacology ◽

10.1111/bcp.14528 ◽

2020 ◽

Author(s):

Trevor N. Johnson ◽

Khaled Abduljalil ◽

Jean‐Marie Nicolas ◽

Pierandrea Muglia ◽

Hugues Chanteux ◽

...

Keyword(s):

Clinical Trial ◽

Initial Dose ◽

Pharmacodynamic Model ◽

Paediatric Clinical Trial ◽

Dose Prediction ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Bayesian Calibration of a Physiologically Based Pharmacokinetic/Pharmacodynamic Model of Carbaryl Cholinesterase Inhibition

Journal of Toxicology and Environmental Health Part A ◽

10.1080/15287390802271608 ◽

2008 ◽

Vol 71 (20) ◽

pp. 1363-1381 ◽

Author(s):

Andy Nong ◽

Yu-Mei Tan ◽

Michael E. Krolski ◽

Jiansuo Wang ◽

Curt Lunchick ◽

...

Keyword(s):

Pharmacodynamic Model ◽

Cholinesterase Inhibition ◽

Bayesian Calibration ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Predicting Antitumor Effect of Deoxypodophyllotoxin in NCI-H460 Tumor-Bearing Mice on the Basis of In Vitro Pharmacodynamics and a Physiologically Based Pharmacokinetic-Pharmacodynamic Model

Drug Metabolism and Disposition ◽

10.1124/dmd.117.079830 ◽

2018 ◽

Vol 46 (6) ◽

pp. 897-907 ◽

Author(s):

Yang Chen ◽

Kaijing Zhao ◽

Fei Liu ◽

Ying Li ◽

Zeyu Zhong ◽

...

Keyword(s):

Antitumor Effect ◽

Pharmacodynamic Model ◽

Tumor Bearing ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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A Population Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Inhibition of 11-β-Hydroxysteroid Dehydrogenase Activity by Glycyrrhetic Acid

Toxicology and Applied Pharmacology ◽

10.1006/taap.2000.9078 ◽

2001 ◽

Vol 170 (1) ◽

pp. 46-55 ◽

Author(s):

Bart Ploeger ◽

Tjeert Mensinga ◽

Adriënne Sips ◽

Caroline Deerenberg ◽

Jan Meulenbelt ◽

...

Keyword(s):

Dehydrogenase Activity ◽

Hydroxysteroid Dehydrogenase ◽

Pharmacodynamic Model ◽

Glycyrrhetic Acid ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Development of a physiologically based pharmacokinetic and pharmacodynamic model to determine dosimetry and cholinesterase inhibition for a binary mixture of chlorpyrifos and diazinon in the rat

NeuroToxicology ◽

10.1016/j.neuro.2008.02.004 ◽

2008 ◽

Vol 29 (3) ◽

pp. 428-443 ◽

Author(s):

C. Timchalk ◽

T.S. Poet

Keyword(s):

Binary Mixture ◽

Pharmacodynamic Model ◽

Cholinesterase Inhibition ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Caffeine Disposition in Pregnancy

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.8b01276 ◽

2019 ◽

Vol 16 (3) ◽

pp. 1340-1349 ◽

Author(s):

Lucy I. Darakjian ◽

Amal Kaddoumi

Keyword(s):

Pharmacodynamic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

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Derivation of human Biomonitoring Guidance Values for chlorpyrifos using a physiologically based pharmacokinetic and pharmacodynamic model of cholinesterase inhibition

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2014.12.013 ◽

2015 ◽

Vol 71 (2) ◽

pp. 235-243 ◽

Author(s):

Scott M. Arnold ◽

Alistair Morriss ◽

Joseph Velovitch ◽

Daland Juberg ◽

Carol J. Burns ◽

...

Keyword(s):

Human Biomonitoring ◽

Pharmacodynamic Model ◽

Cholinesterase Inhibition ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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