The patch test, skin prick test, and serum milk-specific IgE as diagnostic tools in cow's milk allergy in infants

Background Soy-based formula as an alternative to cow's milkformula is preferable to extensively hydrolyzed protein formulabecause of the lower cost and more acceptable taste. However,cow's milk allergy patients can subsequently develop a sensitivityto soy protein.Objective To compare soy protein sensitization in children withand without an allergy to cow's milk.Methods This study was conducted in Yogyakarta from September2007 until March 2008. Subjects were children aged below 4years with an atopic history. Subjects were divided into 2 groups:those with a positive skin prick test to cow's milk and thosewith a negative skin prick test to cow's milk (control group).Both groups were given soy formula and tested at 6 weeks forsensitization to soy.Results There were 45 children in each group. Age, sex, andatopic history were similar in both groups. We found no soyprotein sensitization (negative skin prick results) in all subjectsfrom both groups.Conclusion Risk of immunoglobulin E-mediated sensitizationto soy protein was not proven in children with cow's milk allergy.[Paediatr lndones. 2012;52:67-71).

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Skin prick test subtypes and clinical phenotypes of IgE-mediated cow's milk allergy

Journal of Allergy and Clinical Immunology ◽

10.1016/s0091-6749(02)81784-5 ◽

2002 ◽

Vol 109 (1) ◽

pp. S216-S216

Author(s):

Christopher C Copenhaver ◽

Robert H Schwartz

Keyword(s):

Skin Prick Test ◽

Cow’S Milk Allergy ◽

Cow’S Milk ◽

Milk Allergy ◽

Prick Test ◽

Cow's Milk ◽

Clinical Phenotypes ◽

Cow's Milk Allergy ◽

Ige Mediated

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Diagnostic value of skin-prick and patch tests and serum eosinophil cationic protein and cow's milk-specific IgE in infants with cow's milk allergy

Clinical & Experimental Allergy ◽

10.1046/j.1365-2222.2001.01015.x ◽

2001 ◽

Vol 31 (3) ◽

pp. 423-429 ◽

Cited By ~ 76

Author(s):

K. M. Saarinen ◽

H. Suomalainen ◽

E. Savilahti

Keyword(s):

Eosinophil Cationic Protein ◽

Specific Ige ◽

Diagnostic Value ◽

Cow’S Milk Allergy ◽

Cow’S Milk ◽

Milk Allergy ◽

Cationic Protein ◽

Patch Tests ◽

Cow's Milk ◽

Cow's Milk Allergy

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Efficacy and safety of oral desensitization in children with cow's milk allergy according to their serum specific IgE level

Annals of Allergy Asthma & Immunology ◽

10.1016/j.anai.2013.01.013 ◽

2013 ◽

Vol 110 (4) ◽

pp. 290-294 ◽

Cited By ~ 24

Author(s):

Carmen García-Ara ◽

María Pedrosa ◽

María Teresa Belver ◽

María Flor Martín-Muñoz ◽

Santiago Quirce ◽

...

Keyword(s):

Specific Ige ◽

Cow’S Milk Allergy ◽

Cow’S Milk ◽

Milk Allergy ◽

Efficacy And Safety ◽

Cow's Milk ◽

Cow's Milk Allergy ◽

Oral Desensitization

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Allergy

PEDIATRICS ◽

10.1542/peds.87.6.985 ◽

1991 ◽

Vol 87 (6) ◽

pp. 985-992

Keyword(s):

Solid Phase ◽

Milk Proteins ◽

Subsequent Development ◽

Specific Ige ◽

Cow’S Milk Allergy ◽

Cow’S Milk ◽

Milk Allergy ◽

Cow's Milk ◽

Cow's Milk Allergy ◽

Β Lactoglobulin

Pathophysiology MATERNAL IMMUNE STATUS AGAINST β-LACTOGLOBULIN AND COW'S MILK ALLERGY IN THE INFANT Casmir GJA, Duchateau J, Cuvelier P, Vis HL. Ann Allergy. 1989;63:517-519 Purpose of the Study The reported frequency of cow's milk allergy in children varies between 0.3% and 7.5% (population with earlier weaning has higher incidence). A thorough family history of atopy and cord IgE level at birth have been used to predict infants "at risk." Previous studies have shown that high cord IgE level (exceeding 1 IU/mL) was predictive of subsequent development of atopic disease. The purpose of this study was to follow-up the predictive relationship of maternal IgG-anti-BLG (IgG against β-lactoglobulin which is a major cow's milk antigen) and allergic manifestations in the infant. Study Population: Subject Section Mothers. All women were selected from the obstetric department of St Pierre Hospital in Brussels, Belgium. Infants. 69 infants were chosen who were born to these mothers by vaginal delivery and were fed cow's milk. Methods Clinical Evaluation. Every month during the first 6 months of life, infants were examined clinically for allergic symptoms. Gastrointestinal signs (diarrhea, vomiting, colic), atopic dermatitis, and respiratory problems (asthma, chronic cough, rhinitis) were recorded. Symptomatic children were treated with Alfare (Nestle) containing hydrolysates of cow's milk proteins with minimal allergenicity. Biologic Investigations. IgG-anti-BLG levels in mothers' sera were measured using solid-phase radioimmunoassay method. These levels were expressed in arbitrary units per milliliter. All children were screened for total IgE levels at 5 days of age. Specific IgE anti-cow's milk radioallergosorbent tests (RASTs) were performed in all patients at 1 month of age.

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