Haemodynamic monitoring and liver function evaluation by pulsion cold system Z-201 (PCS) during orthotopic liver transplantation

2003 ◽  
Vol 17 (1) ◽  
pp. 47-55 ◽  
Author(s):  
Susana Diaz ◽  
Jose Perez-Pena ◽  
Javier Sanz ◽  
Luis Olmedilla ◽  
Ignacio Garutti ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Function ◽  
Orthotopic Liver Transplantation ◽  
Haemodynamic Monitoring ◽  
Function Evaluation

Optimizing the Management of Abnormal Liver Function Tests after Orthotopic Liver Transplant: A Systems-Based Analysis of Health Care Utilization

2017 ◽  
Vol 83 (10) ◽  
pp. 1152-1156 ◽  
Author(s):  
Tara A. Russell ◽  
Stephanie A. K. Angarita ◽  
Amy Showen ◽  
Vatche Agopian ◽  
Ronald W. Busuttil ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Function ◽  
Viral Hepatitis ◽  
Orthotopic Liver Transplantation ◽  
Liver Function Tests ◽  
Acute Cellular Rejection ◽  
Diagnostic Workup ◽  
Not Otherwise Specified ◽  
Bed Days ◽  
Cellular Rejection

Elevated liver function tests (eLFTs) are a major cause of unplanned readmissions (UR) after orthotopic liver transplantation. Diagnostic workup for eLFTs requires multiple invasive and noninvasive procedures, often done in the inpatient setting to expedite diagnosis, yet consequently resulting in increased costs. In this study, we evaluated eLFT readmissions at a single institution with respect to resource utilization. From 3/2013 to 12/2015, 388 patients underwent orthotopic liver transplantation, resulting in 463 UR totaling 5833 bed days; 87 (18.8%) UR and 929 (15.9%) bed days were for eLFTs. During eLFT-UR all patients underwent repeat laboratory testing, 75 (86.2%) liver ultrasound, 66 (75.8%) liver biopsy, and 17 (19.5%) endoscopic retrograde cholangiopancreatography. Discharge diagnoses were acute cellular rejection (40.2%), transaminitis not otherwise specified (17.2%), biliary complications (16.1%), recurrent hepatitis (11.5%), vascular complications (5.8%), viral hepatitis (5.8%), and steatohepatitis (3.5%). The greatest bed-day utilization was secondary to acute cellular rejection (60.8%) and biliary complications (13.7%). More than 35 per cent of eLFT-UR were due to transaminitis not otherwise specified, steatohepatitis, recurrent or viral hepatitis, none of which necessitate inpatient treatment. In addition, >25 per cent of eLFT-UR bed days were attributed to diagnostic workup. Identifying patients who can undergo expedited outpatient workup and require only outpatient management will result in significantly decreased readmissions, bed days, and hospital costs.

scholarly journals Effect of iloprost on the microcirculation and liver function after orthotopic liver transplantation

Critical Care ◽  
2008 ◽  
Vol 12 (Suppl 2) ◽  
pp. P59
Author(s):  
S Klinzing ◽  
C Stumme ◽  
K Albin ◽  
O Habrecht ◽  
U Settmacher ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Function ◽  
Orthotopic Liver Transplantation

scholarly journals In vitro and in vivo characteristics of hepatic oval cells modified with human hepatocyte growth factor

2013 ◽  
Vol 18 (4) ◽  
Author(s):  
Zhu Li ◽  
Juan Chen ◽  
Li Li ◽  
Jiang-Hua Ran ◽  
Xue-Hua Li ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Growth Factor ◽  
Liver Function ◽  
Hepatocyte Growth Factor ◽  
Orthotopic Liver Transplantation ◽  
Peak Time ◽  
Oval Cells ◽  
Hepatic Oval Cells ◽  
Hepatocyte Growth

AbstractHepatocyte growth factor (HGF) is a multifunctional growth factor that controls cell scattering. It has been suggested that it regulates the proliferation of hepatic oval cells (HOCs). Using a HOC line that stably expresses the human HGF gene (hHGF), we investigated the in vitro proliferation and differentiation characteristics of hHGF-modified HOCs and explored their potential capacity for intrahepatic transplantation. A modified 2-acetylaminofluorene and partial hepatectomy (2-AAF/PH) model was established to activate the proliferation of oval cells in the rat liver. HOCs were transfected with the pBLAST2-hHGF plasmid and hHGF-carrying HOCs were selected based on blasticidin resistance. The level of hHGF secretion was determined via ELISA. Cell proliferation was determined using the MTT assay. Differentiation was induced by growth factor withdrawal. A two-cuff technique was used for orthotopic liver transplantation, and HOCs or hHGF-modified HOCs were transplanted into the recipients. The levels of biochemical indicators of liver function were measured after transplantation. An HOC line stably expressing hHGF was established. The transfected line showed greater hHGF secretion than normal HOCs. The hHGF gene promoted the proliferation capability of HOCs by reducing the peak time in vitro. The hHGF-modified HOCs differentiated into hepatocytes and bile duct epithelial cells upon growth factor withdrawal in vitro. In addition, hHGF-modified HOC transplantation significantly prolonged the median survival time (MST) and improved the liver function of recipients compared to HOC transplant recipients and nontransplanted controls. Our results indicate that hHGF-modified HOCs may have valuable properties for therapeutic liver regeneration after orthotopic liver transplantation.

Orthotopic liver transplantation provides a survival advantage compared with resection in patients with hepatocellular carcinoma and preserved liver function

Surgery ◽  
2017 ◽  
Vol 162 (5) ◽  
pp. 1032-1039 ◽  
Author(s):  
Jason B. Liu ◽  
Talia B. Baker ◽  
Nicholas R. Suss ◽  
Mark S. Talamonti ◽  
Kevin K. Roggin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Liver Function ◽  
Orthotopic Liver Transplantation ◽  
Survival Advantage

Methionine breath test to assess mithocondrial liver function after orthotopic liver transplantation

2001 ◽  
Vol 120 (5) ◽  
pp. A373
Author(s):  
Giuseppina Angelini ◽  
Marcello Candelli ◽  
Bruno Nardo ◽  
Cristiana Di Campli ◽  
Alessandro Armuzzi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Function ◽  
Orthotopic Liver Transplantation ◽  
Breath Test
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