The effects of alcohol and multiple drug abuse on violent behavior were studied with a sample of 110 men charged with first degree or capital murder. Subjects were divided into four groups based upon whether they were sober, drinking alcohol, using alcohol and other drugs in combination, or whether they were abusing only non-alcoholic drugs at the time of the murder. These four groups were compared on 15 sociological, behavioral, and demographic variables. Nine of these variables significantly differentiated the groups. Recommendations for intervention and future research are made.