Objective: to identify clinically significant functional interactions between the autonomic nervous system and personal emotional sphere.Material and methods. 105 patients with cardiovascular diseases were examined. Using a clinical role-playing game, the states of the psycho-emotional arousal of modalities: «anger», «fear», «sadness», and «joy» with some intervals of relaxation between them were successively induced in the patients, and the intensity of the psycho-emotional arousal was also recorded. At the same time, the parameters of heart rate variability were registered using the KP-01 Holter monitoring system. The patients were divided into two groups depending on the presence of a high direct relationship between the recorded indicators.Results. It has been found that a high direct relationship (rs[9] = 0.70, p = 0.018) of the power spectral density in the low frequency range, the total index of autonomic disequilibrium, and the intensity of emotional responses is associated with a 3-4 risk of arterial hypertension, coronary heart disease , cardiosclerosis, chronic heart failure.Conclusion. The presence of these correlations is associated with cardiovascular disease and is an independent risk factor for its development.