The study documents some of the multicultural challenges experienced by South African clinical psychologists and how these are addressed within the context of clinical practice, supervision, and training. This mail survey of 241 clinical psychologists registered with the Health Professions Council of South Africa during the year 2015, explored everyday clinical and supervisory practices. Multicultural training experiences were also studied. Findings indicated that multicultural challenges were experienced by 74.3% of respondents in clinical practice and by 34.3% of participants involved in supervision of clinicians and/or interns. Difficulties were related to cultural belief systems, language, specific therapeutic and supervisory obstacles, as well as socio-political and economic issues. Approaches employed to address these challenges primarily involved the use of therapeutic processes, positioning, and paradigms. An emphasis on lifelong learning processes was also present. Although evidence for multicultural competency and orientation was apparent in addressing these difficulties, findings suggest a need for more awareness and in-depth training in these areas.