Supplemental Material for The Effects of Inhaled Flavors on Intravenous Nicotine

2020 ◽  
Keyword(s):  
Intravenous Nicotine

scholarly journals Galantamine attenuates some of the subjective effects of intravenous nicotine and improves performance on a Go No-Go task in abstinent cigarette smokers: a preliminary report

2012 ◽  
Vol 224 (3) ◽  
pp. 413-420 ◽  
Author(s):  
Mehmet Sofuoglu ◽  
Aryeh I. Herman ◽  
Yisheng Li ◽  
Andrew J. Waters
Keyword(s):  
Preliminary Report ◽  
Subjective Effects ◽  
Cigarette Smokers ◽  
Intravenous Nicotine

scholarly journals Varenicline attenuates some of the subjective and physiological effects of intravenous nicotine in humans

2009 ◽  
Vol 207 (1) ◽  
pp. 153-162 ◽  
Author(s):  
Mehmet Sofuoglu ◽  
Aryeh I. Herman ◽  
Marc Mooney ◽  
Andrew J. Waters
Keyword(s):  
Physiological Effects ◽  
Intravenous Nicotine

Inhibition of spinal afferent nerve-mediated gastric hyperemia by nicotine: role of ganglionic blockade

1993 ◽  
Vol 264 (4) ◽  
pp. H1087-H1092
Author(s):  
F. W. Leung
Keyword(s):  
Blood Flow ◽  
Afferent Nerve ◽  
Gastric Blood Flow ◽  
Doppler Flowmetry ◽  
Afferent Nerves ◽  
Vasodilatory Effect ◽  
Blocking Property ◽  
Intravenous Nicotine ◽  
Ganglionic Blocking ◽  
Stimulation Of

The hypothesis that intravenous nicotine modulates gastric spinal afferent nerve function by its ganglionic-blocking property is tested. Stimulation of the gastric spinal afferent nerves in anesthetized rats is accomplished by intragastric capsaicin irrigation. Gastric blood flow is monitored by laser-Doppler flowmetry. The increase in gastric blood flow during intragastric capsaicin irrigation is significantly reduced by 4 and 40 micrograms.kg-1.min-1 of intravenous nicotine. The inhibition appears to be specific for the spinal afferent nerves as the increase in gastric blood flow induced by electrical stimulation of the vagal afferent nerves is unaltered by these doses of intravenous nicotine. A ganglionic-blocking dose (10 mg/kg) of intraperitoneal hexamethonium also significantly attenuates the gastric vasodilatory effect of intragastric capsaicin. Intravenous nicotine (40 micrograms.kg-1.min-1) combined with intraperitoneal hexamethonium (10 mg/kg) completely abolishes the gastric vasodilatory effect of intragastric capsaicin. These data suggest that intravenous nicotine offers a specific inhibition of the gastric spinal afferent nerve-mediated hyperemia, possibly as a consequence of its ganglionic-blocking property.

scholarly journals Acute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers

2018 ◽  
Vol 32 (9) ◽  
pp. 986-994 ◽  
Author(s):  
Gerald W Valentine ◽  
Elise E DeVito ◽  
Peter I Jatlow ◽  
Ralitza Gueorguieva ◽  
Mehmet Sofuoglu
Keyword(s):  
Random Sequence ◽  
Subjective Effects ◽  
Random Order ◽  
Test Session ◽  
Controlled Study ◽  
Nicotine Metabolism ◽  
Double Blind ◽  
Subjective Responses ◽  
Intravenous Nicotine ◽  
Nicotine Deprivation

Objective: This double-blind, placebo controlled study examined whether menthol inhaled from an electronic cigarette (e-cigarette) would change subjective and withdrawal alleviating effects of intravenous nicotine in young adult smokers. Methods: A total of 32 menthol-preferring smokers and 25 non-menthol-preferring smokers participated in the study that consisted of a random sequence of three different inhaled menthol conditions (0.0%, 0.5%, and 3.2%) across three test sessions (a single menthol condition per session). In each test session (performed at least 24 hours apart), a random order of saline, and two different nicotine infusions of 0.25 mg and 0.5 mg/70 kg of bodyweight were administered, one hour apart, concurrent with menthol inhalation. Results: While menthol did not alter the positive subjective effects of nicotine, menthol significantly enhanced aversive effects of nicotine in non-menthol-preferring smokers and reduced smoking urges in menthol-preferring smokers. In addition, menthol-preferring smokers reported blunted positive subjective responses to nicotine and less severe nicotine withdrawal after overnight nicotine deprivation. Finally, compared to non-menthol-preferring smokers, menthol-preferring smokers had a significantly lower baseline nicotine metabolite ratio indicating slower nicotine metabolism within our sample of menthol-preferring smokers. Conclusions: Our findings did not support an enhancement of nicotine’s positive subjective effects from inhaled menthol. However, as compared to non-menthol-preferring smokers, menthol-preferring smokers had blunted positive subjective responses to nicotine and reduced overnight withdrawal severity that may be partly due to inhibition of nicotine metabolism from chronic exposure to inhaled menthol. Collectively, these results reveal a more complex and nuanced role of inhaled menthol in smokers than previously recognized.

Reboxetine: Attenuation of Intravenous Nicotine Self-Administration in Rats

2002 ◽  
Vol 303 (2) ◽  
pp. 664-672 ◽  
Author(s):  
Anthony S. Rauhut ◽  
Stephanie N. Mullins ◽  
Linda P. Dwoskin ◽  
Michael T. Bardo
Keyword(s):  
Self Administration ◽  
Intravenous Nicotine

scholarly journals A Demonstration of Intravenous Nicotine Self-Administration in Humans?

2008 ◽  
Vol 33 (8) ◽  
pp. 2042-2043 ◽  
Author(s):  
Heather G Fulton ◽  
Sean P Barrett
Keyword(s):  
Self Administration ◽  
Intravenous Nicotine

scholarly journals Subjective, Physiological, and Cognitive Responses to Intravenous Nicotine: Effects of Sex and Menstrual Cycle Phase

2013 ◽  
Vol 39 (6) ◽  
pp. 1431-1440 ◽  
Author(s):  
Elise E DeVito ◽  
Aryeh I Herman ◽  
Andrew J Waters ◽  
Gerald W Valentine ◽  
Mehmet Sofuoglu
Keyword(s):  
Menstrual Cycle ◽  
Cycle Phase ◽  
Cognitive Responses ◽  
Menstrual Cycle Phase ◽  
Intravenous Nicotine
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