Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants

10.1038/12687 ◽  
1999 ◽  
Vol 23 (1) ◽  
pp. 81-85 ◽  
Author(s):  
Clark Chen ◽  
Richard D. Kolodner
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Chromosomal Rearrangements ◽  
Gross Chromosomal Rearrangements

Suppression of gross chromosomal rearrangements by the multiple functions of the Mre11–Rad50–Xrs2 complex in Saccharomyces cerevisiae

DNA Repair ◽  
2005 ◽  
Vol 4 (5) ◽  
pp. 606-617 ◽  
Author(s):  
Stephanie Smith ◽  
Amitabha Gupta ◽  
Richard D. Kolodner ◽  
Kyungjae Myung
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Chromosomal Rearrangements ◽  
Multiple Functions ◽  
Gross Chromosomal Rearrangements

Analysis of Gross‐Chromosomal Rearrangements in Saccharomyces cerevisiae

2006 ◽  
pp. 462-476 ◽  
Author(s):  
Kristina H. Schmidt ◽  
Vincent Pennaneach ◽  
Christopher D. Putnam ◽  
Richard D. Kolodner
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Chromosomal Rearrangements ◽  
Gross Chromosomal Rearrangements

scholarly journals Stimulation of Gross Chromosomal Rearrangements by the Human CEB1 and CEB25 Minisatellites in Saccharomyces cerevisiae Depends on G-Quadruplexes or Cdc13

PLoS Genetics ◽  
2012 ◽  
Vol 8 (11) ◽  
pp. e1003033 ◽  
Author(s):  
Aurèle Piazza ◽  
Alexandre Serero ◽  
Jean-Baptiste Boulé ◽  
Patricia Legoix-Né ◽  
Judith Lopes ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Chromosomal Rearrangements ◽  
Gross Chromosomal Rearrangements ◽  
Stimulation Of

scholarly journals The Rad1-Rad10 Complex Promotes the Production of Gross Chromosomal Rearrangements From Spontaneous DNA Damage in Saccharomyces cerevisiae

Genetics ◽  
2005 ◽  
Vol 169 (4) ◽  
pp. 1927-1937 ◽  
Author(s):  
Ji-Young Hwang ◽  
Stephanie Smith ◽  
Kyungjae Myung
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Dna Damage ◽  
Chromosomal Rearrangements ◽  
Gross Chromosomal Rearrangements

scholarly journals Functions of Saccharomyces cerevisiae 14-3-3 Proteins in Response to DNA Damage and to DNA Replication Stress

Genetics ◽  
2003 ◽  
Vol 165 (4) ◽  
pp. 1717-1732
Author(s):  
Francisca Lottersberger ◽  
Fabio Rubert ◽  
Veronica Baldo ◽  
Giovanna Lucchini ◽  
Maria Pia Longhese
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Dna Damage ◽  
Dna Replication ◽  
Genome Instability ◽  
Chromosomal Rearrangements ◽  
Replication Stress ◽  
Checkpoint Kinases ◽  
Gross Chromosomal Rearrangements ◽  
Dna Damage Checkpoints ◽  
Dna Replication Stress

Abstract Two members of the 14-3-3 protein family, involved in key biological processes in different eukaryotes, are encoded by the functionally redundant Saccharomyces cerevisiae BMH1 and BMH2 genes. We produced and characterized 12 independent bmh1 mutant alleles, whose presence in the cell as the sole 14-3-3 source causes hypersensitivity to genotoxic agents, indicating that Bmh proteins are required for proper response to DNA damage. In particular, the bmh1-103 and bmh1-266 mutant alleles cause defects in G1/S and G2/M DNA damage checkpoints, whereas only the G2/M checkpoint is altered by the bmh1-169 and bmh1-221 alleles. Impaired checkpoint responses correlate with the inability to maintain phosphorylated forms of Rad53 and/or Chk1, suggesting that Bmh proteins might regulate phosphorylation/dephosphorylation of these checkpoint kinases. Moreover, several bmh1 bmh2Δ mutants are defective in resuming DNA replication after transient deoxynucleotide depletion, and all display synthetic effects when also carrying mutations affecting the polα-primase and RPA DNA replication complexes, suggesting a role for Bmh proteins in DNA replication stress response. Finally, the bmh1-169 bmh2Δ and bmh1-170 bmh2Δ mutants show increased rates of spontaneous gross chromosomal rearrangements, indicating that Bmh proteins are required to suppress genome instability.

scholarly journals Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors

2019 ◽  
Vol 116 (35) ◽  
pp. 17377-17382 ◽  
Author(s):  
Anjana Srivatsan ◽  
Binzhong Li ◽  
Dafne N. Sanchez ◽  
Steven B. Somach ◽  
Vandeclecio L. da Silva ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Genome Instability ◽  
Protein Complexes ◽  
Chromosomal Rearrangements ◽  
Human Tumor ◽  
Temperature Sensitive ◽  
Temperature Sensitive Mutants ◽  
Gross Chromosomal Rearrangements ◽  
Human Genes ◽  
Significant Enrichment

Gross Chromosomal Rearrangements (GCRs) play an important role in human diseases, including cancer. Although most of the nonessential Genome Instability Suppressing (GIS) genes in Saccharomyces cerevisiae are known, the essential genes in which mutations can cause increased GCR rates are not well understood. Here 2 S. cerevisiae GCR assays were used to screen a targeted collection of temperature-sensitive mutants to identify mutations that caused increased GCR rates. This identified 94 essential GIS (eGIS) genes in which mutations cause increased GCR rates and 38 candidate eGIS genes that encode eGIS1 protein-interacting or family member proteins. Analysis of TCGA data using the human genes predicted to encode the proteins and protein complexes implicated by the S. cerevisiae eGIS genes revealed a significant enrichment of mutations affecting predicted human eGIS genes in 10 of the 16 cancers analyzed.

scholarly journals Ploidy influences cellular responses to gross chromosomal rearrangements in saccharomyces cerevisiae

BMC Genomics ◽  
2011 ◽  
Vol 12 (1) ◽  
Author(s):  
Paul P Jung ◽  
Emilie S Fritsch ◽  
Corinne Blugeon ◽  
Jean-Luc Souciet ◽  
Serge Potier ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Chromosomal Rearrangements ◽  
Cellular Responses ◽  
Gross Chromosomal Rearrangements
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