Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

Nature ◽  
1990 ◽  
Vol 348 (6299) ◽  
pp. 334-336 ◽  
Author(s):  
David Hockenbery ◽  
Gabriel Nuñez ◽  
Curt Milliman ◽  
Robert D. Schreiber ◽  
Stanley J. Korsmeyer
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Membrane Protein ◽  
Mitochondrial Membrane ◽  
Inner Mitochondrial Membrane ◽  
Mitochondrial Membrane Protein

scholarly journals A Multisubunit Complex of Outer and Inner Mitochondrial Membrane Protein Translocases Stabilizedin Vivoby Translocation Intermediates

1999 ◽  
Vol 274 (32) ◽  
pp. 22847-22854 ◽  
Author(s):  
Norbert Schülke ◽  
Naresh Babu V. Sepuri ◽  
Donna M. Gordon ◽  
Sandeep Saxena ◽  
Andrew Dancis ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Mitochondrial Membrane ◽  
Inner Mitochondrial Membrane ◽  
Mitochondrial Membrane Protein

scholarly journals Consequences of inner mitochondrial membrane protein misfolding

Mitochondrion ◽  
2019 ◽  
Vol 49 ◽  
pp. 46-55 ◽  
Author(s):  
Liam P. Coyne ◽  
Xin Jie Chen
Keyword(s):  
Membrane Protein ◽  
Protein Misfolding ◽  
Mitochondrial Membrane ◽  
Inner Mitochondrial Membrane ◽  
Mitochondrial Membrane Protein

scholarly journals ChChd3, an Inner Mitochondrial Membrane Protein is Essential for Maintaining Cristae Integrity and Mitochondrial Function

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Manjula Darshi ◽  
Guy A Perkins ◽  
Mason R Mackey ◽  
Susanna Petrosyan ◽  
Anne N Murphy ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Mitochondrial Function ◽  
Mitochondrial Membrane ◽  
Inner Mitochondrial Membrane ◽  
Mitochondrial Membrane Protein

Underappreciated Roles of the Translocase of the Outer and Inner Mitochondrial Membrane Protein Complexes in Human Disease

2019 ◽  
Vol 38 (1) ◽  
pp. 23-40 ◽  
Author(s):  
Thea Heinemeyer ◽  
Monique Stemmet ◽  
Soraya Bardien ◽  
Annika Neethling
Keyword(s):  
Membrane Protein ◽  
Human Disease ◽  
Mitochondrial Membrane ◽  
Protein Complexes ◽  
Inner Mitochondrial Membrane ◽  
Membrane Protein Complexes ◽  
Mitochondrial Membrane Protein

scholarly journals Inactivation of YME2/RNA12, which encodes an integral inner mitochondrial membrane protein, causes increased escape of DNA from mitochondria to the nucleus in Saccharomyces cerevisiae.

1996 ◽  
Vol 16 (6) ◽  
pp. 2764-2771 ◽  
Author(s):  
T Hanekamp ◽  
P E Thorsness
Keyword(s):  
Membrane Protein ◽  
Mitochondrial Membrane ◽  
Nuclear Gene ◽  
Genetic Interactions ◽  
Yeast Cells ◽  
Null Alleles ◽  
Growth Defect ◽  
Inner Mitochondrial Membrane ◽  
Synthetic Growth ◽  
Mitochondrial Membrane Protein

Inactivation of the yeast nuclear gene YMe2 causes an increased rate of DNA escape from mitochondria to the nucleus. Mutations in yme2 also show genetic interactions with yme1, a second gene that affects DNA escape from mitochondria to the nucleus. The yme1 cold-sensitive growth phenotype is suppressed by yme2 mutations. In addition, yme1 yme2 double mutants exhibit a synthetic growth defect on ethanol-glycerol medium at 30 degrees C. YME2 was isolated by complementation of the synthetic growth defect of yme1 yme2 strains and was found to be identical with the previously cloned RNA12 gene. The dominant temperature-sensitive mutation RNA12-1 prevents growth of yeast cells at 37 degrees C. YME2 encodes a protein with a predicted molecular weight of 96,681 and is an integral inner mitochondrial membrane protein. The larger carboxyl-terminal domain of the YME2 gene product faces the intermembrane space. Null alleles of yme2 display the same genetic interactions with yme1 and high rate of DNA escape from mitochondria as do the originally isolated yme2 mutant strains. Disruption of yme2 causes a strain-dependent growth defect on nonfermentable carbon sources.

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