Long-term Combination Therapy with Anti-TNF plus Vedolizumab Induces and Maintains Remission in Therapy-refractory Ulcerative Colitis

2017 ◽  
Vol 112 (10) ◽  
pp. 1621-1623 ◽  
Author(s):  
Sarah Fischer ◽  
Timo Rath ◽  
Carol-Immanuel Geppert ◽  
Bernhard Manger ◽  
Georg Schett ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Combination Therapy

scholarly journals Successful cyclosporin and ustekinumab combination therapy in a patient with severe steroid-refractory ulcerative colitis

2020 ◽  
Vol 13 ◽  
pp. 175628482095411 ◽  
Author(s):  
Ingo Ganzleben ◽  
Carol Geppert ◽  
Lourdes Osaba ◽  
Simon Hirschmann ◽  
Andreas Nägel ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Combination Therapy ◽  
Ulcerative Colitis Patient ◽  
Induction Treatment ◽  
Colitis Patient ◽  
Endoscopic Remission ◽  
Term Benefit ◽  
Steroid Refractory

The therapeutic management of patients with severe steroid-refractory ulcerative colitis still represents a critical clinical challenge. In this setting, cyclosporin is an effective and rapidly acting induction treatment that is applied in combination with maintenance therapeutic agents like thiopurines or vedolizumab. Here, we present the case of a 33-year-old ulcerative colitis patient with severe steroid-refractory ulcerative colitis who refused surgical intervention and previously demonstrated no long-term benefit to anti-TNF antibody, vedolizumab, cyclosporin, thiopurines or tofacitinib treatment. Intravenous cyclosporin therapy was re-initiated in the patient and, after signs of clinical response, therapy with ustekinumab was additionally applied. After 11 weeks of well tolerated cyclosporin and ustekinumab combination therapy, cyclosporin was discontinued upon clinical and endoscopic remission. Subsequently, ustekinumab treatment has been effective in maintaining remission during the follow-up period of 195 days.

scholarly journals Long-Term Alteration of Intestinal Microbiota in Patients with Ulcerative Colitis by Antibiotic Combination Therapy

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e86702 ◽  
Author(s):  
Shigeo Koido ◽  
Toshifumi Ohkusa ◽  
Takayuki Kajiura ◽  
Junko Shinozaki ◽  
Manabu Suzuki ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Combination Therapy ◽  
Intestinal Microbiota ◽  
Antibiotic Combination

Long-term Combination Therapy with Infliximab Plus Azathioprine Predicts Sustained Steroid-free Clinical Benefit in Steroid-dependent Ulcerative Colitis

2014 ◽  
Vol 20 (8) ◽  
pp. 1368-1374 ◽  
Author(s):  
Alessandro Armuzzi ◽  
Daniela Pugliese ◽  
Silvio Danese ◽  
Gianluca Rizzo ◽  
Carla Felice ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Combination Therapy ◽  
Clinical Benefit ◽  
Steroid Dependent

Long-term outcome of treatment with cyclosporine IV for patients with intractable ulcerative colitis

2001 ◽  
Vol 120 (5) ◽  
pp. A624-A624 ◽  
Author(s):  
J ARTS ◽  
M ZEEGERS ◽  
G DHAENS ◽  
G VANASSCHE ◽  
M HIELE ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Term Outcome ◽  
Long Term Outcome
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