Extramedullary plasmacytoma of the head and neck region: clinicopathological correlation in 25 cases

ABSTRACT Extramedullary plasmacytoma (EMP) is a rarely seen neoplasm of plasma cells which may be locally destructive by involving submucosal soft tissues of upper respiratory tract but without systemic dissemination. It comprises less than 1% of head and neck malignities. Clinical presentation depends on tumor's effect and its involvement site. Diagnosis is made with histopathologic examination of tissue biopsy. Responses to its treatment with local radiotherapy and surgery are similar. In this article; it is intended to update our knowledge regarding EMP and remind this rarely encountered disease by presenting various cases detected in nasopharynx, tonsil, buccal mucosa, larynx, mastoid cavity and sphenoid sinus, with literature line. How to cite this article Öztürk K, Şahin M, Midilli R, Gürsan G, Özsan N, Savaş R. Extramedullary Plasmacytoma of Head and Neck Region: Report of Six Cases with Different Localizations. Int J Otorhinolaryngol Clin 2013;5(3):157-163.

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Three cases of extramedullary plasmacytoma originating in the head and neck region.

Practica Oto-Rhino-Laryngologica ◽

10.5631/jibirin.80.257 ◽

1987 ◽

Vol 80 (2) ◽

pp. 257-265

Author(s):

Shinya Matsunaga ◽

Takuo Maeyama ◽

Tetsuya Shima ◽

Kazuyoshi Ueno ◽

Ichiro Moriyama ◽

...

Keyword(s):

Head And Neck ◽

Neck Region ◽

Extramedullary Plasmacytoma ◽

Head And Neck Region

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Combined modality therapy for naso-oropharyngeal solitary extramedullary plasmacytoma: case report

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20174342 ◽

2017 ◽

Vol 3 (4) ◽

pp. 1105

Author(s):

Andrea Masarykova ◽

Marin Dzongov ◽

Alexandra Hanicova ◽

Ingrid Zavacka ◽

Danijela Scepanovic

Keyword(s):

Case Report ◽

Head And Neck ◽

Plasma Cell ◽

Fdg Pet ◽

Neck Region ◽

Extramedullary Plasmacytoma ◽

Head And Neck Region ◽

Pet Ct ◽

Fdg Pet Ct ◽

Solitary Extramedullary Plasmacytoma

<p>Most patients with plasma cell neoplasia have generalized disease at diagnosis. However, some patients have a solitary extramedullary plasmacytomas (SEPs). SEPs are rare, typically solitary tumors comprising approximately 3–5% all plasma cell neoplasms. Almost 90% arise in the head and neck region, especially in the nasal cavity, sinuses, oropharynx, salivary glands and larynx. Solitary extramedullary plasmacytoma (SEP) has a predilection for the male gender and occurs most frequently in patients 50 years and older. SEP often runs an indolent clinical course with a tendency for local recurrence, and progresses to plasma cell myeloma in about 15% of patients. In this paper, we have reported the case of SEP of the naso-oropharynx in 55 years old woman who was presented with a sense of the nasal obstruction. The resection was performed and a mature plasmacytoma was demonstrated histologically. However, ENT examination and positron emission tomography/computed tomography examination with 18-fluorodeoxyglucose (18-FDG PET/CT) have shown that the patient had residual naso-oropharyngeal disease after surgery. A negative bone marrow biopsy and 18-FDG PET/CT have confirmed that it was a solitary extramedullary plasmacytoma of the head and neck region. Following the surgery, intensity modulated radiotherapy (IMRT) was administered. No relapse or progression to the multiple myeloma was recorded during the 3.5 years of follow-up. This case report, which describes a rare tumor of the naso-oropharynx, is expected to improve the recognition and referral of this condition in medical practice. </p>

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Extramedullary Plasmacytoma of Head and Neck Region: Report of Six Cases with Different Localizations

Otorhinolaryngology Clinics - An International Journal ◽

10.5005/aijoc-6-3-10 ◽

2014 ◽

Vol 6 (3) ◽

pp. 10-16 ◽

Cited By ~ 1

Author(s):

Kerem Öztürk ◽

Mustafa Şahin ◽

Raşit Midilli ◽

Gülce Gürsan ◽

Nazan Özsan ◽

...

Keyword(s):

Head And Neck ◽

Soft Tissues ◽

Plasma Cells ◽

Neck Region ◽

Extramedullary Plasmacytoma ◽

Mastoid Cavity ◽

Upper Respiratory Tract ◽

Head And Neck Region ◽

Systemic Dissemination ◽

Upper Respiratory

ABSTRACT Extramedullary plasmacytoma (EMP) is a rarely seen neoplasm of plasma cells which may be locally destructive by involving submucosal soft tissues of upper respiratory tract but without systemic dissemination. It comprises less than 1% of head and neck malignities. Clinical presentation depends on tumor's effect and its involvement site. Diagnosis is made with histopathologic examination of tissue biopsy. Responses to its treatment with local radiotherapy and surgery are similar. In this article; it is intended to update our knowledge regarding EMP and remind this rarely encountered disease by presenting various cases detected in nasopharynx, tonsil, buccal mucosa, larynx, mastoid cavity and sphenoid sinus, with literature line.

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Retroperitoneal Plasmacytoma: A Case Report

Journal of Bangladesh College of Physicians and Surgeons ◽

10.3329/jbcps.v30i3.12467 ◽

2012 ◽

Vol 30 (3) ◽

pp. 167-169

Author(s):

SM Amjad Hossain ◽

Mohammad Rafiz Imtiaz ◽

Gopal Verma

Keyword(s):

Case Report ◽

Head And Neck ◽

Neck Region ◽

Extramedullary Plasmacytoma ◽

Elderly Male ◽

College Hospital ◽

Head And Neck Region ◽

First Report ◽

Rare Neoplasm ◽

Medical College

Solitary Extramedullary Primary Plasmacytoma (SEMPP) is a rare neoplasm. When diagnosed, head and neck region is its most likely location. Rarely, it may occur in the retroperitoneum. We report a case of an elderly male who was admitted in the department of surgery, Dhaka Medical College Hospital (DMCH) with a Solitary Extramedullary Retroperitoneal Primary Plasmacytoma (SEMRPP). Subtotal excision of the mass was done. The patient was referred to the department of Oncology DMC for radiotherapy. The first report of an extramedullary plasmacytoma was in 1905 in Taiwan. To the best of our knowledge, there was no report of a Solitary Extramedullary Retroperitoneal Primary Plasmacytoma (SEMRPP) from Bangladesh.DOI: http://dx.doi.org/10.3329/jbcps.v30i3.12467 J Bangladesh Coll Phys Surg 2012; 30: 167-169

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Extramedullary Plasmacytoma of Nasal Cavity

Clinical Rhinology An International Journal ◽

10.5005/jp-journals-10013-1265 ◽

2016 ◽

Vol 9 (1) ◽

pp. 50-52

Author(s):

Ravi Meher ◽

Swati Tandon

Keyword(s):

Nasal Cavity ◽

Head And Neck ◽

Soft Tissues ◽

Plasma Cells ◽

Neck Region ◽

Extramedullary Plasmacytoma ◽

Upper Aerodigestive Tract ◽

Head And Neck Region ◽

Plasma Cell Neoplasms ◽

Extramedullary Plasmacytomas

ABSTRACT Extramedullary plasmacytoma is a rare neoplasm characterized by monoclonal proliferation of plasma cells in soft tissues. Extramedullary plasmacytomas constitute 3 to 5% of all plasma cell neoplasms. Most lesions occur in the head and neck, primarily in the upper aerodigestive tract, with 75% occurring in nose and paranasal sinuses. To the best of our knowledge, only few cases of sinonasal extramedullary plasmacytomas have been reported in the literature. It is important for otolaryngologists to acquire knowledge of this disease as 80 to 90% occur in the head and neck region. We report a rare case of extramedullary plasmacytoma of the nasal cavity in a 60-year-old male managed by surgery and radiotherapy. How to cite this article Tandon S, Meher R, Chauhan A. Extramedullary Plasmacytoma of Nasal Cavity. Clin Rhinol An Int J 2016;9(1):50-52.

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